Free for buyers, contact details stay privateFree for buyers. Your contact details stay private until you accept a quote.

Sign in Join free

Murcko scaffold

Ring system with 4 rings and 19 atoms

46 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 19
Chemicals: 46
With full pages: 8

Scaffold SMILES

O=c1c2c3c(sc2ncn1-c1ccccc1)CCC3

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=c1c2c3c(sc2ncn1-c1ccccc1)CCC3

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 46 of 46 chemicals

6-Allylsulfanyl-5-p-tolyl-1,2,3,5-tetrahydro-8-thia-5,7-diaza-cyclopenta[a]inden-4-one chemical structure, C19H18N2OS2, CAS 309272-15-9

6-Allylsulfanyl-5-p-tolyl-1,2,3,5-tetrahydro-8-thia-5,7-diaza-cyclopenta[a]inden-4-one

CAS 309272-15-9C₁₉H₁₈N₂OS₂

(4-Oxo-5-phenyl-2,3,4,5-tetrahydro-1H-8-thia-5,7-diaza-cyclopenta[a]inden-6-ylsulfanyl)-acetic acid, methyl ester chemical structure, C18H16N2O3S2, CAS 329721-75-7

(4-Oxo-5-phenyl-2,3,4,5-tetrahydro-1H-8-thia-5,7-diaza-cyclopenta[a]inden-6-ylsulfanyl)-acetic acid, methyl ester

CAS 329721-75-7C₁₈H₁₆N₂O₃S₂

2-(Methylsulfanyl)-3-phenyl-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one chemical structure, C16H14N2OS2, CAS 346638-45-7

2-(Methylsulfanyl)-3-phenyl-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one

CAS 346638-45-7C₁₆H₁₄N₂OS₂

3-Ethylsulfanyl-2-(4-methylphenyl)-7,8-dihydro-6H-cyclopenta[2,3]thieno[2,4-b]pyrimidin-1-one chemical structure, C18H18N2OS2, CAS 312585-60-7

3-Ethylsulfanyl-2-(4-methylphenyl)-7,8-dihydro-6H-cyclopenta[2,3]thieno[2,4-b]pyrimidin-1-one

CAS 312585-60-7C₁₈H₁₈N₂OS₂

3-(4-Methylphenyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one chemical structure, C16H14N2OS, CAS 312946-70-6

3-(4-Methylphenyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one

CAS 312946-70-6C₁₆H₁₄N₂OS

3-(4-Methylphenyl)-2-(methylsulfanyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one chemical structure, C17H16N2OS2, CAS 337351-75-4

3-(4-Methylphenyl)-2-(methylsulfanyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one

CAS 337351-75-4C₁₇H₁₆N₂OS₂

3-(3-Methoxyphenyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one chemical structure, C16H14N2O2S, CAS 461654-58-0

3-(3-Methoxyphenyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one

CAS 461654-58-0C₁₆H₁₄N₂O₂S

2-[(2-Oxopropyl)thio]-3-phenyl-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one chemical structure, C18H16N2O2S2, CAS 315685-18-8

2-[(2-Oxopropyl)thio]-3-phenyl-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one

CAS 315685-18-8C₁₈H₁₆N₂O₂S₂

Methyl 2-{[11-(4-chlorophenyl)-12-oxo-7-thia-9,11-diazatricyclo[6.4.0.0,2,6]dodeca-1(8),2(6),9-trien-10-yl]sulfanyl}acetate chemical structure, C18H15ClN2O3S2, CAS 676581-53-6

Methyl 2-{[11-(4-chlorophenyl)-12-oxo-7-thia-9,11-diazatricyclo[6.4.0.0,2,6]dodeca-1(8),2(6),9-trien-10-yl]sulfanyl}acetate

CAS 676581-53-6C₁₈H₁₅ClN₂O₃S₂

Isopropyl {[3-(4-chlorophenyl)-4-oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-D]pyrimidin-2-yl]sulfanyl}acetate chemical structure, C20H19ClN2O3S2, CAS 677293-97-9

Isopropyl {[3-(4-chlorophenyl)-4-oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-D]pyrimidin-2-yl]sulfanyl}acetate

CAS 677293-97-9C₂₀H₁₉ClN₂O₃S₂

Ethyl [(4-oxo-3-phenyl-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)sulfanyl]acetate chemical structure, C19H18N2O3S2, CAS 312946-36-4

Ethyl [(4-oxo-3-phenyl-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)sulfanyl]acetate

CAS 312946-36-4C₁₉H₁₈N₂O₃S₂

{[3-(4-Methoxyphenyl)-4-oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl]sulfanyl}acetic acid chemical structure, C18H16N2O4S2, CAS 351159-67-6

{[3-(4-Methoxyphenyl)-4-oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl]sulfanyl}acetic acid

CAS 351159-67-6C₁₈H₁₆N₂O₄S₂

Methyl 2-[[2-(4-methoxyphenyl)-1-oxo-7,8-dihydro-6H-cyclopenta[2,3]thieno[2,4-b]pyrimidin-3-yl]sulfanyl]acetate chemical structure, C19H18N2O4S2, CAS 351440-68-1

Methyl 2-[[2-(4-methoxyphenyl)-1-oxo-7,8-dihydro-6H-cyclopenta[2,3]thieno[2,4-b]pyrimidin-3-yl]sulfanyl]acetate

CAS 351440-68-1C₁₉H₁₈N₂O₄S₂

2-{[3-(4-Methylphenyl)-4-oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl]sulfanyl}acetamide chemical structure, C18H17N3O2S2, CAS 351160-51-5

2-{[3-(4-Methylphenyl)-4-oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl]sulfanyl}acetamide

CAS 351160-51-5C₁₈H₁₇N₃O₂S₂

3-(4-Methylphenyl)-2-[(2-methyl-2-propenyl)sulfanyl]-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one chemical structure, C20H20N2OS2, CAS 337351-61-8

3-(4-Methylphenyl)-2-[(2-methyl-2-propenyl)sulfanyl]-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one

CAS 337351-61-8C₂₀H₂₀N₂OS₂

Ethyl 2-[[2-(4-methylphenyl)-1-oxo-7,8-dihydro-6H-cyclopenta[2,3]thieno[2,4-b]pyrimidin-3-yl]sulfanyl]acetate chemical structure, C20H20N2O3S2, CAS 330946-12-8

Ethyl 2-[[2-(4-methylphenyl)-1-oxo-7,8-dihydro-6H-cyclopenta[2,3]thieno[2,4-b]pyrimidin-3-yl]sulfanyl]acetate

CAS 330946-12-8C₂₀H₂₀N₂O₃S₂

2-[(2-Methyl-2-propenyl)sulfanyl]-3-phenyl-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one chemical structure, C19H18N2OS2, CAS 352657-35-3

2-[(2-Methyl-2-propenyl)sulfanyl]-3-phenyl-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one

CAS 352657-35-3C₁₉H₁₈N₂OS₂

2-(4-Methoxyphenyl)-3-(2-methylprop-2-enylsulfanyl)-7,8-dihydro-6H-cyclopenta[2,3]thieno[2,4-b]pyrimidin-1-one chemical structure, C20H20N2O2S2, CAS 332145-21-8

2-(4-Methoxyphenyl)-3-(2-methylprop-2-enylsulfanyl)-7,8-dihydro-6H-cyclopenta[2,3]thieno[2,4-b]pyrimidin-1-one

CAS 332145-21-8C₂₀H₂₀N₂O₂S₂

$N,N-Dimethyl-2-({12-oxo-11-phenyl-7-thia-9,11-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(8),2(6),9-trien-10-yl}sulfanyl)acetamide chemical structure, C19H19N3O2S2, CAS 496026-20-1$

N,N-Dimethyl-2-({12-oxo-11-phenyl-7-thia-9,11-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(8),2(6),9-trien-10-yl}sulfanyl)acetamide

CAS 496026-20-1C₁₉H₁₉N₃O₂S₂

Methyl {[3-(4-methylphenyl)-4-oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl]sulfanyl}acetate chemical structure, C19H18N2O3S2, CAS 374083-74-6

Methyl {[3-(4-methylphenyl)-4-oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl]sulfanyl}acetate

CAS 374083-74-6C₁₉H₁₈N₂O₃S₂

2-(2-Methoxyphenyl)-3-(2-methylprop-2-enylsulfanyl)-7,8-dihydro-6H-cyclopenta[2,3]thieno[2,4-b]pyrimidin-1-one chemical structure, C20H20N2O2S2, CAS 376370-54-6

2-(2-Methoxyphenyl)-3-(2-methylprop-2-enylsulfanyl)-7,8-dihydro-6H-cyclopenta[2,3]thieno[2,4-b]pyrimidin-1-one

CAS 376370-54-6C₂₀H₂₀N₂O₂S₂

2-(Isopropylthio)-3-(o-tolyl)-6,7-dihydro-3H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4(5H)-one chemical structure, C19H20N2OS2, CAS 380882-59-7

2-(Isopropylthio)-3-(o-tolyl)-6,7-dihydro-3H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4(5H)-one

CAS 380882-59-7C₁₉H₂₀N₂OS₂

3-(4-Methoxyphenyl)-2-[(3-methylbutyl)sulfanyl]-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one chemical structure, C21H24N2O2S2, CAS 330833-70-0

3-(4-Methoxyphenyl)-2-[(3-methylbutyl)sulfanyl]-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one

CAS 330833-70-0C₂₁H₂₄N₂O₂S₂

2-{[3-(4-Chlorophenyl)-4-oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl]sulfanyl}-N,N-diethylacetamide chemical structure, C21H22ClN3O2S2, CAS 613227-03-5

2-{[3-(4-Chlorophenyl)-4-oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl]sulfanyl}-N,N-diethylacetamide

CAS 613227-03-5C₂₁H₂₂ClN₃O₂S₂