Murcko scaffold
Ring system with 5 rings and 32 atoms
24 chemicals on CompoundList share this ring system.
- Rings
- 5
- Scaffold atoms
- 32
- Chemicals
- 24
- With full pages
- 3
Scaffold SMILES
O=C1C(=O)N(CCN2CCOCC2)C(c2ccccc2)C1=Cc1ccc2c(c1)OCCO2
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 24 of 24 chemicals
![4-(2,3-Dihydro-1,4-benzodioxine-6-carbonyl)-3-hydroxy-5-(3-hydroxyphenyl)-1-[2-(morpholin-4-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H26N2O7](/s/PXFICWDYVTYNPI-UHFFFAOYSA-N.svg)
4-(2,3-Dihydro-1,4-benzodioxine-6-carbonyl)-3-hydroxy-5-(3-hydroxyphenyl)-1-[2-(morpholin-4-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one
C25H26N2O7
![4-[2,3-Dihydro-1,4-benzodioxin-6-yl(hydroxy)methylidene]-5-(4-methylphenyl)-1-(2-morpholin-4-ylethyl)pyrrolidine-2,3-dione chemical structure, C26H28N2O6](/s/HFISHANSXNSBRR-UHFFFAOYSA-N.svg)
4-[2,3-Dihydro-1,4-benzodioxin-6-yl(hydroxy)methylidene]-5-(4-methylphenyl)-1-(2-morpholin-4-ylethyl)pyrrolidine-2,3-dione
C26H28N2O6
![4-(2,3-Dihydro-1,4-benzodioxine-6-carbonyl)-5-(2-fluorophenyl)-3-hydroxy-1-[2-(morpholin-4-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H25FN2O6](/s/BLZSCKMYRSAYJS-UHFFFAOYSA-N.svg)
4-(2,3-Dihydro-1,4-benzodioxine-6-carbonyl)-5-(2-fluorophenyl)-3-hydroxy-1-[2-(morpholin-4-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one
C25H25FN2O6
![4-(2,3-Dihydro-1,4-benzodioxine-6-carbonyl)-3-hydroxy-5-(4-methoxyphenyl)-1-[2-(morpholin-4-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H28N2O7](/s/ACDCCZUFTXDRNZ-UHFFFAOYSA-N.svg)
4-(2,3-Dihydro-1,4-benzodioxine-6-carbonyl)-3-hydroxy-5-(4-methoxyphenyl)-1-[2-(morpholin-4-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one
C26H28N2O7
![4-(2,3-Dihydro-1,4-benzodioxine-6-carbonyl)-5-(3-ethoxyphenyl)-3-hydroxy-1-[2-(morpholin-4-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C27H30N2O7](/s/OLWOJMKZZIIHML-UHFFFAOYSA-N.svg)
4-(2,3-Dihydro-1,4-benzodioxine-6-carbonyl)-5-(3-ethoxyphenyl)-3-hydroxy-1-[2-(morpholin-4-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one
C27H30N2O7
![5-(3-Chlorophenyl)-4-[2,3-dihydro-1,4-benzodioxin-6-yl(hydroxy)methylidene]-1-(2-morpholin-4-ylethyl)pyrrolidine-2,3-dione chemical structure, C25H25ClN2O6](/s/PNGVROHNFBIGLA-UHFFFAOYSA-N.svg)
5-(3-Chlorophenyl)-4-[2,3-dihydro-1,4-benzodioxin-6-yl(hydroxy)methylidene]-1-(2-morpholin-4-ylethyl)pyrrolidine-2,3-dione
C25H25ClN2O6
![4-(2,3-Dihydro-1,4-benzodioxine-6-carbonyl)-3-hydroxy-1-[2-(morpholin-4-yl)ethyl]-5-[4-(propan-2-yl)phenyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C28H32N2O6](/s/HNVMUFRCZYONCS-UHFFFAOYSA-N.svg)
4-(2,3-Dihydro-1,4-benzodioxine-6-carbonyl)-3-hydroxy-1-[2-(morpholin-4-yl)ethyl]-5-[4-(propan-2-yl)phenyl]-2,5-dihydro-1H-pyrrol-2-one
C28H32N2O6
![4-(2,3-Dihydro-1,4-benzodioxine-6-carbonyl)-3-hydroxy-1-[2-(morpholin-4-yl)ethyl]-5-phenyl-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H26N2O6](/s/SYRGHROFPKMAQY-UHFFFAOYSA-N.svg)
4-(2,3-Dihydro-1,4-benzodioxine-6-carbonyl)-3-hydroxy-1-[2-(morpholin-4-yl)ethyl]-5-phenyl-2,5-dihydro-1H-pyrrol-2-one
C25H26N2O6
![4-(2,3-Dihydro-1,4-benzodioxine-6-carbonyl)-5-(4-fluorophenyl)-3-hydroxy-1-[2-(morpholin-4-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H25FN2O6](/s/XSASWURGEWSMPX-UHFFFAOYSA-N.svg)
4-(2,3-Dihydro-1,4-benzodioxine-6-carbonyl)-5-(4-fluorophenyl)-3-hydroxy-1-[2-(morpholin-4-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one
C25H25FN2O6
![4-(2,3-Dihydro-1,4-benzodioxine-6-carbonyl)-5-(4-ethoxyphenyl)-3-hydroxy-1-[2-(morpholin-4-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C27H30N2O7](/s/UKYJJDMJBKBXMT-UHFFFAOYSA-N.svg)
4-(2,3-Dihydro-1,4-benzodioxine-6-carbonyl)-5-(4-ethoxyphenyl)-3-hydroxy-1-[2-(morpholin-4-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one
C27H30N2O7
![4-(2,3-Dihydro-1,4-benzodioxine-6-carbonyl)-5-(4-ethylphenyl)-3-hydroxy-1-[2-(morpholin-4-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C27H30N2O6](/s/LDKMTGVNWFDEAL-UHFFFAOYSA-N.svg)
4-(2,3-Dihydro-1,4-benzodioxine-6-carbonyl)-5-(4-ethylphenyl)-3-hydroxy-1-[2-(morpholin-4-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one
C27H30N2O6
![4-(2,3-Dihydro-1,4-benzodioxine-6-carbonyl)-3-hydroxy-5-(3-methoxyphenyl)-1-[2-(morpholin-4-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H28N2O7](/s/ZEIKPHSQKISSED-UHFFFAOYSA-N.svg)
4-(2,3-Dihydro-1,4-benzodioxine-6-carbonyl)-3-hydroxy-5-(3-methoxyphenyl)-1-[2-(morpholin-4-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one
C26H28N2O7
![4-(2,3-Dihydrobenzo[b][1,4]dioxine-6-carbonyl)-3-hydroxy-5-(3-hydroxyphenyl)-1-(2-morpholinoethyl)-1H-pyrrol-2(5H)-one chemical structure, C25H26N2O7, CAS 620560-52-3](/s/PXFICWDYVTYNPI-XTQSDGFTSA-N.svg)
4-(2,3-Dihydrobenzo[b][1,4]dioxine-6-carbonyl)-3-hydroxy-5-(3-hydroxyphenyl)-1-(2-morpholinoethyl)-1H-pyrrol-2(5H)-one
CAS 620560-52-3C25H26N2O7
![4-(2,3-Dihydro-1,4-benzodioxine-6-carbonyl)-3-hydroxy-5-(4-methylphenyl)-1-[2-(morpholin-4-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H28N2O6, CAS 618419-08-2](/s/HFISHANSXNSBRR-ZNTNEXAZSA-N.svg)
4-(2,3-Dihydro-1,4-benzodioxine-6-carbonyl)-3-hydroxy-5-(4-methylphenyl)-1-[2-(morpholin-4-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one
CAS 618419-08-2C26H28N2O6
![4-(2,3-Dihydrobenzo[b][1,4]dioxine-6-carbonyl)-5-(2-fluorophenyl)-3-hydroxy-1-(2-morpholinoethyl)-1H-pyrrol-2(5H)-one chemical structure, C25H25FN2O6, CAS 578734-09-5](/s/BLZSCKMYRSAYJS-XTQSDGFTSA-N.svg)
4-(2,3-Dihydrobenzo[b][1,4]dioxine-6-carbonyl)-5-(2-fluorophenyl)-3-hydroxy-1-(2-morpholinoethyl)-1H-pyrrol-2(5H)-one
CAS 578734-09-5C25H25FN2O6
![4-(2,3-Dihydrobenzo[b][1,4]dioxine-6-carbonyl)-3-hydroxy-5-(4-methoxyphenyl)-1-(2-morpholinoethyl)-1H-pyrrol-2(5H)-one chemical structure, C26H28N2O7, CAS 586991-73-3](/s/ACDCCZUFTXDRNZ-ZNTNEXAZSA-N.svg)
4-(2,3-Dihydrobenzo[b][1,4]dioxine-6-carbonyl)-3-hydroxy-5-(4-methoxyphenyl)-1-(2-morpholinoethyl)-1H-pyrrol-2(5H)-one
CAS 586991-73-3C26H28N2O7
![4-(2,3-Dihydrobenzo[b][1,4]dioxine-6-carbonyl)-5-(3-ethoxyphenyl)-3-hydroxy-1-(2-morpholinoethyl)-1H-pyrrol-2(5H)-one chemical structure, C27H30N2O7, CAS 620560-66-9](/s/OLWOJMKZZIIHML-WJTDDFOZSA-N.svg)
4-(2,3-Dihydrobenzo[b][1,4]dioxine-6-carbonyl)-5-(3-ethoxyphenyl)-3-hydroxy-1-(2-morpholinoethyl)-1H-pyrrol-2(5H)-one
CAS 620560-66-9C27H30N2O7
![5-(3-Chlorophenyl)-4-(2,3-dihydro-1,4-benzodioxine-6-carbonyl)-3-hydroxy-1-[2-(morpholin-4-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H25ClN2O6, CAS 620560-49-8](/s/PNGVROHNFBIGLA-XTQSDGFTSA-N.svg)
5-(3-Chlorophenyl)-4-(2,3-dihydro-1,4-benzodioxine-6-carbonyl)-3-hydroxy-1-[2-(morpholin-4-yl)ethyl]-2,5-dihydro-1H-pyrrol-2-one
CAS 620560-49-8C25H25ClN2O6
![4-(2,3-Dihydro-1,4-benzodioxin-6-ylcarbonyl)-3-hydroxy-5-(4-isopropylphenyl)-1-[2-(4-morpholinyl)ethyl]-1,5-dihydro-2H-pyrrol-2-one chemical structure, C28H32N2O6, CAS 620560-32-9](/s/HNVMUFRCZYONCS-SHHOIMCASA-N.svg)
4-(2,3-Dihydro-1,4-benzodioxin-6-ylcarbonyl)-3-hydroxy-5-(4-isopropylphenyl)-1-[2-(4-morpholinyl)ethyl]-1,5-dihydro-2H-pyrrol-2-one
CAS 620560-32-9C28H32N2O6
![4-(2,3-Dihydro-1,4-benzodioxin-6-ylcarbonyl)-3-hydroxy-1-[2-(4-morpholinyl)ethyl]-5-phenyl-1,5-dihydro-2H-pyrrol-2-one chemical structure, C25H26N2O6, CAS 618418-92-1](/s/SYRGHROFPKMAQY-XTQSDGFTSA-N.svg)
4-(2,3-Dihydro-1,4-benzodioxin-6-ylcarbonyl)-3-hydroxy-1-[2-(4-morpholinyl)ethyl]-5-phenyl-1,5-dihydro-2H-pyrrol-2-one
CAS 618418-92-1C25H26N2O6
![(4E)-4-[2,3-Dihydro-1,4-benzodioxin-6-yl(hydroxy)methylidene]-5-(4-fluorophenyl)-1-(2-morpholin-4-ylethyl)pyrrolidine-2,3-dione chemical structure, C25H25FN2O6, CAS 618419-40-2](/s/XSASWURGEWSMPX-XTQSDGFTSA-N.svg)
(4E)-4-[2,3-Dihydro-1,4-benzodioxin-6-yl(hydroxy)methylidene]-5-(4-fluorophenyl)-1-(2-morpholin-4-ylethyl)pyrrolidine-2,3-dione
CAS 618419-40-2C25H25FN2O6
![(4E)-4-[2,3-Dihydro-1,4-benzodioxin-6-yl(hydroxy)methylidene]-5-(4-ethoxyphenyl)-1-(2-morpholin-4-ylethyl)pyrrolidine-2,3-dione chemical structure, C27H30N2O7, CAS 618420-45-4](/s/UKYJJDMJBKBXMT-WJTDDFOZSA-N.svg)
(4E)-4-[2,3-Dihydro-1,4-benzodioxin-6-yl(hydroxy)methylidene]-5-(4-ethoxyphenyl)-1-(2-morpholin-4-ylethyl)pyrrolidine-2,3-dione
CAS 618420-45-4C27H30N2O7
![(4E)-4-[2,3-Dihydro-1,4-benzodioxin-6-yl(hydroxy)methylidene]-5-(4-ethylphenyl)-1-(2-morpholin-4-ylethyl)pyrrolidine-2,3-dione chemical structure, C27H30N2O6, CAS 618420-95-4](/s/LDKMTGVNWFDEAL-WJTDDFOZSA-N.svg)
(4E)-4-[2,3-Dihydro-1,4-benzodioxin-6-yl(hydroxy)methylidene]-5-(4-ethylphenyl)-1-(2-morpholin-4-ylethyl)pyrrolidine-2,3-dione
CAS 618420-95-4C27H30N2O6
![(4E)-4-[2,3-Dihydro-1,4-benzodioxin-6-yl(hydroxy)methylidene]-5-(3-methoxyphenyl)-1-(2-morpholin-4-ylethyl)pyrrolidine-2,3-dione chemical structure, C26H28N2O7, CAS 618421-22-0](/s/ZEIKPHSQKISSED-ZNTNEXAZSA-N.svg)
(4E)-4-[2,3-Dihydro-1,4-benzodioxin-6-yl(hydroxy)methylidene]-5-(3-methoxyphenyl)-1-(2-morpholin-4-ylethyl)pyrrolidine-2,3-dione
CAS 618421-22-0C26H28N2O7
Related scaffolds
Same ring framework with different atoms or bond orders
