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Murcko scaffold

Ring system with 4 rings and 25 atoms

15 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
15
With full pages
1
Scaffold SMILES

O=C(Nc1cccc2ccccc12)Nc1ccnn1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1cccc2ccccc12)Nc1ccnn1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 15 of 15 chemicals

3-[3-[3-tert-Butyl-5-[3-(naphthalen-1-yl)ureido]-1H-pyrazol-1-yl]phenyl]propionic acid chemical structure, C27H28N4O3, CAS 725686-34-0
3-[3-[3-tert-Butyl-5-[3-(naphthalen-1-yl)ureido]-1H-pyrazol-1-yl]phenyl]propionic acid
CAS 725686-34-0C27H28N4O3
N-(4-Bromonaphthalen-1-yl)-N'-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]urea chemical structure, C25H25BrN4O, CAS 285984-26-1
N-(4-Bromonaphthalen-1-yl)-N'-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]urea
CAS 285984-26-1C25H25BrN4O
3-[3-tert-Butyl-5-[3-(naphthalen-1-yl)ureido]-1H-pyrazol-1-yl]benzoic acid chemical structure, C25H24N4O3, CAS 872171-59-0
3-[3-tert-Butyl-5-[3-(naphthalen-1-yl)ureido]-1H-pyrazol-1-yl]benzoic acid
CAS 872171-59-0C25H24N4O3
Ethyl 3-(3-(tert-butyl)-5-(3-(naphthalen-1-yl)ureido)-1H-pyrazol-1-yl)benzoate chemical structure, C27H28N4O3, CAS 725685-94-9
Ethyl 3-(3-(tert-butyl)-5-(3-(naphthalen-1-yl)ureido)-1H-pyrazol-1-yl)benzoate
CAS 725685-94-9C27H28N4O3
1-(1-(3-(Azidomethyl)phenyl)-3-(tert-butyl)-1H-pyrazol-5-yl)-3-(naphthalen-1-yl)urea chemical structure, C25H25N7O, CAS 725686-03-3
1-(1-(3-(Azidomethyl)phenyl)-3-(tert-butyl)-1H-pyrazol-5-yl)-3-(naphthalen-1-yl)urea
CAS 725686-03-3C25H25N7O
1-{3-tert-Butyl-1-[3-(hydroxymethyl)phenyl]-1H-pyrazol-5-yl}-3-(naphthalen-1-yl)urea chemical structure, C25H26N4O2, CAS 725685-96-1
1-{3-tert-Butyl-1-[3-(hydroxymethyl)phenyl]-1H-pyrazol-5-yl}-3-(naphthalen-1-yl)urea
CAS 725685-96-1C25H26N4O2
N-{1-[4-(Aminomethyl)phenyl]-3-tert-butyl-1H-pyrazol-5-yl}-N'-naphthalen-1-ylurea chemical structure, C25H27N5O, CAS 725686-56-6
N-{1-[4-(Aminomethyl)phenyl]-3-tert-butyl-1H-pyrazol-5-yl}-N'-naphthalen-1-ylurea
CAS 725686-56-6C25H27N5O
1-(3-(tert-Butyl)-1-(3-(chloromethyl)phenyl)-1H-pyrazol-5-yl)-3-(naphthalen-1-yl)urea chemical structure, C25H25ClN4O, CAS 725685-97-2
1-(3-(tert-Butyl)-1-(3-(chloromethyl)phenyl)-1H-pyrazol-5-yl)-3-(naphthalen-1-yl)urea
CAS 725685-97-2C25H25ClN4O
tert-Butyl [[4-[3-tert-butyl-5-[3-(naphthalen-1-yl)ureido]-1H-pyrazol-1-yl]phenyl]methyl]carbamate chemical structure, C30H35N5O3, CAS 725686-54-4
tert-Butyl [[4-[3-tert-butyl-5-[3-(naphthalen-1-yl)ureido]-1H-pyrazol-1-yl]phenyl]methyl]carbamate
CAS 725686-54-4C30H35N5O3
1-[1-(3-Aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea chemical structure, C24H25N5O, CAS 1160934-70-2
1-[1-(3-Aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea
CAS 1160934-70-2C24H25N5O
1-{3-Tert-Butyl-1-[4-(Hydroxymethyl)phenyl]-1H-Pyrazol-5-Yl}-3-Naphthalen-1-Ylurea chemical structure, C25H26N4O2, CAS 903567-33-9
1-{3-Tert-Butyl-1-[4-(Hydroxymethyl)phenyl]-1H-Pyrazol-5-Yl}-3-Naphthalen-1-Ylurea
CAS 903567-33-9C25H26N4O2
3-(3-tert-Butyl-5-{[(naphthalen-1-yl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(4-hydroxybutyl)benzamide chemical structure, C29H33N5O3, CAS 2650654-33-2
3-(3-tert-Butyl-5-{[(naphthalen-1-yl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(4-hydroxybutyl)benzamide
CAS 2650654-33-2C29H33N5O3
Ethyl 3-[5-(naphthalen-1-ylcarbamoylamino)-3-(trifluoromethyl)pyrazol-1-yl]benzoate chemical structure, C24H19F3N4O3, CAS 903567-09-9
Ethyl 3-[5-(naphthalen-1-ylcarbamoylamino)-3-(trifluoromethyl)pyrazol-1-yl]benzoate
CAS 903567-09-9C24H19F3N4O3
Ethyl 2-[3-[3-tert-butyl-5-[3-(naphthalen-1-yl)ureido]-1H-pyrazol-1-yl]phenyl]acetate chemical structure, C28H30N4O3, CAS 897375-32-5
Ethyl 2-[3-[3-tert-butyl-5-[3-(naphthalen-1-yl)ureido]-1H-pyrazol-1-yl]phenyl]acetate
CAS 897375-32-5C28H30N4O3
1-(3-(tert-Butyl)-1-(3-(2-hydroxyethyl)phenyl)-1H-pyrazol-5-yl)-3-(naphthalen-1-yl)urea chemical structure, C26H28N4O2, CAS 897370-80-8
1-(3-(tert-Butyl)-1-(3-(2-hydroxyethyl)phenyl)-1H-pyrazol-5-yl)-3-(naphthalen-1-yl)urea
CAS 897370-80-8C26H28N4O2