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Murcko scaffold

4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-N-phenylbenzamide scaffold

27 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
27
With full pages
8
Scaffold SMILES

O=C(Nc1ccccc1)c1ccc(CN2CCc3ccccc3C2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-N-phenylbenzamide page
Murcko scaffold O=C(Nc1ccccc1)c1ccc(CN2CCc3ccccc3C2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 27 of 27 chemicals

4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-N-(4-iodo-2-methylphenyl)benzamide chemical structure, C24H23IN2O, CAS 663160-43-8
4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-N-(4-iodo-2-methylphenyl)benzamide
CAS 663160-43-8C24H23IN2O
4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-N-(2,6-dimethylphenyl)benzamide chemical structure, C25H26N2O, CAS 352559-32-1
4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-N-(2,6-dimethylphenyl)benzamide
CAS 352559-32-1C25H26N2O
4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-N-(2-fluorophenyl)benzamide chemical structure, C23H21FN2O, CAS 426226-87-1
4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-N-(2-fluorophenyl)benzamide
CAS 426226-87-1C23H21FN2O
4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-N-(3-methylphenyl)benzamide chemical structure, C24H24N2O, CAS 333358-16-0
4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-N-(3-methylphenyl)benzamide
CAS 333358-16-0C24H24N2O
4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-N-(3,5-dimethylphenyl)benzamide chemical structure, C25H26N2O, CAS 333358-21-7
4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-N-(3,5-dimethylphenyl)benzamide
CAS 333358-21-7C25H26N2O
4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-N-(2-ethylphenyl)benzamide chemical structure, C25H26N2O, CAS 333358-22-8
4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-N-(2-ethylphenyl)benzamide
CAS 333358-22-8C25H26N2O
N-(2,4-Dichlorophenyl)-4-(3,4-dihydroisoquinolin-2(1H)-ylmethyl)benzamide chemical structure, C23H20Cl2N2O, CAS 333358-26-2
N-(2,4-Dichlorophenyl)-4-(3,4-dihydroisoquinolin-2(1H)-ylmethyl)benzamide
CAS 333358-26-2C23H20Cl2N2O
N-(2,4-Difluorophenyl)-4-(3,4-dihydro-2(1H)-isoquinolinylmethyl)benzamide chemical structure, C23H20F2N2O, CAS 532982-08-4
N-(2,4-Difluorophenyl)-4-(3,4-dihydro-2(1H)-isoquinolinylmethyl)benzamide
CAS 532982-08-4C23H20F2N2O
N-(4-Acetamidophenyl)-4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)benzamide chemical structure, C25H25N3O2, CAS 664318-51-8
N-(4-Acetamidophenyl)-4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)benzamide
CAS 664318-51-8C25H25N3O2
4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-N-(2,4-dimethylphenyl)benzamide chemical structure, C25H26N2O, CAS 333358-18-2
4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-N-(2,4-dimethylphenyl)benzamide
CAS 333358-18-2C25H26N2O
4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-N-(2,5-dimethylphenyl)benzamide chemical structure, C25H26N2O, CAS 333358-19-3
4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-N-(2,5-dimethylphenyl)benzamide
CAS 333358-19-3C25H26N2O
N-(3-Chlorophenyl)-4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)benzamide chemical structure, C23H21ClN2O, CAS 5711-45-5
N-(3-Chlorophenyl)-4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)benzamide
CAS 5711-45-5C23H21ClN2O
4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-N-(4-iodophenyl)benzamide chemical structure, C23H21IN2O, CAS 333358-30-8
4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-N-(4-iodophenyl)benzamide
CAS 333358-30-8C23H21IN2O
Ethyl 4-[[4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)benzoyl]amino]benzoate chemical structure, C26H26N2O3, CAS 329741-12-0
Ethyl 4-[[4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)benzoyl]amino]benzoate
CAS 329741-12-0C26H26N2O3
4-(3,4-Dihydroisoquinolin-2(1H)-ylmethyl)-N-(4-fluorophenyl)benzamide chemical structure, C23H21FN2O, CAS 409354-07-0
4-(3,4-Dihydroisoquinolin-2(1H)-ylmethyl)-N-(4-fluorophenyl)benzamide
CAS 409354-07-0C23H21FN2O
N-(5-Chloro-2-methoxyphenyl)-4-(3,4-dihydroisoquinolin-2(1H)-ylmethyl)benzamide chemical structure, C24H23ClN2O2, CAS 409356-52-1
N-(5-Chloro-2-methoxyphenyl)-4-(3,4-dihydroisoquinolin-2(1H)-ylmethyl)benzamide
CAS 409356-52-1C24H23ClN2O2
4-(3,4-Dihydroisoquinolin-2(1H)-ylmethyl)-N-(2-methoxy-5-methylphenyl)benzamide chemical structure, C25H26N2O2, CAS 526183-88-0
4-(3,4-Dihydroisoquinolin-2(1H)-ylmethyl)-N-(2-methoxy-5-methylphenyl)benzamide
CAS 526183-88-0C25H26N2O2
N-(2,3-Dichlorophenyl)-4-[(3,4-dihydroisoquinolin-2(1H)-yl)methyl]benzamide chemical structure, C23H20Cl2N2O, CAS 5714-19-2
N-(2,3-Dichlorophenyl)-4-[(3,4-dihydroisoquinolin-2(1H)-yl)methyl]benzamide
CAS 5714-19-2C23H20Cl2N2O
N-(2-Bromophenyl)-4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)benzamide chemical structure, C23H21BrN2O, CAS 352559-27-4
N-(2-Bromophenyl)-4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)benzamide
CAS 352559-27-4C23H21BrN2O
N-(3-Chloro-2-methylphenyl)-4-(3,4-dihydroisoquinolin-2(1H)-ylmethyl)benzamide chemical structure, C24H23ClN2O, CAS 494833-27-1
N-(3-Chloro-2-methylphenyl)-4-(3,4-dihydroisoquinolin-2(1H)-ylmethyl)benzamide
CAS 494833-27-1C24H23ClN2O
N-(2,6-Diethylphenyl)-4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)benzamide chemical structure, C27H30N2O, CAS 664318-68-7
N-(2,6-Diethylphenyl)-4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)benzamide
CAS 664318-68-7C27H30N2O
4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-N-(2-methyl-6-propan-2-ylphenyl)benzamide chemical structure, C27H30N2O, CAS 708224-59-3
4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-N-(2-methyl-6-propan-2-ylphenyl)benzamide
CAS 708224-59-3C27H30N2O
4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-N-(4-methoxyphenyl)benzamide chemical structure, C24H24N2O2, CAS 333358-32-0
4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-N-(4-methoxyphenyl)benzamide
CAS 333358-32-0C24H24N2O2
4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-N-(4-propan-2-ylphenyl)benzamide chemical structure, C26H28N2O, CAS 425613-67-8
4-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-N-(4-propan-2-ylphenyl)benzamide
CAS 425613-67-8C26H28N2O