Murcko scaffold
5-(2-Oxo-2-(4-phenylpiperazin-1-yl)ethyl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one scaffold
17 chemicals on CompoundList share this ring system.
- Rings
- 5
- Scaffold atoms
- 31
- Chemicals
- 17
- With full pages
- 4
Scaffold SMILES
O=C(Cn1cnc2c(cnn2-c2ccccc2)c1=O)N1CCN(c2ccccc2)CC1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 17 of 17 chemicals
![1-(4-Fluorophenyl)-5-[2-[4-(2-methoxyphenyl)piperazin-1-yl]-2-oxoethyl]pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C24H23FN6O3, CAS 841211-45-8](/s/YTAZBDCCEHICGL-UHFFFAOYSA-N.svg)
1-(4-Fluorophenyl)-5-[2-[4-(2-methoxyphenyl)piperazin-1-yl]-2-oxoethyl]pyrazolo[3,4-d]pyrimidin-4-one
CAS 841211-45-8C24H23FN6O3
![1-(4-Fluorophenyl)-5-[2-[4-(4-methoxyphenyl)piperazin-1-yl]-2-oxoethyl]pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C24H23FN6O3, CAS 841211-47-0](/s/FJNNBXAJWSZRDE-UHFFFAOYSA-N.svg)
1-(4-Fluorophenyl)-5-[2-[4-(4-methoxyphenyl)piperazin-1-yl]-2-oxoethyl]pyrazolo[3,4-d]pyrimidin-4-one
CAS 841211-47-0C24H23FN6O3
![1-(4-Fluorophenyl)-5-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C23H21FN6O2, CAS 852450-21-6](/s/XCLJMBIULBLFLG-UHFFFAOYSA-N.svg)
1-(4-Fluorophenyl)-5-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]pyrazolo[3,4-d]pyrimidin-4-one
CAS 852450-21-6C23H21FN6O2
![5-(2-Oxo-2-(4-phenylpiperazin-1-yl)ethyl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one chemical structure, C23H22N6O2, CAS 852439-99-7](/s/CDVCJDGGLSRPAW-UHFFFAOYSA-N.svg)
5-(2-Oxo-2-(4-phenylpiperazin-1-yl)ethyl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
CAS 852439-99-7C23H22N6O2
![5-(2-Oxo-2-(4-phenylpiperazin-1-yl)ethyl)-1-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one chemical structure, C24H24N6O2, CAS 863446-30-4](/s/WJYDEHDJTURQEF-UHFFFAOYSA-N.svg)
5-(2-Oxo-2-(4-phenylpiperazin-1-yl)ethyl)-1-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
CAS 863446-30-4C24H24N6O2
![1-(4-Chlorophenyl)-5-(2-oxo-2-(4-phenylpiperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one chemical structure, C23H21ClN6O2, CAS 852440-66-5](/s/RHPITMVIKAJPHD-UHFFFAOYSA-N.svg)
1-(4-Chlorophenyl)-5-(2-oxo-2-(4-phenylpiperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
CAS 852440-66-5C23H21ClN6O2
![1-(3,4-Dimethylphenyl)-5-(2-oxo-2-(4-phenylpiperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one chemical structure, C25H26N6O2, CAS 852451-18-4](/s/DPVQMMNUKRTTTO-UHFFFAOYSA-N.svg)
1-(3,4-Dimethylphenyl)-5-(2-oxo-2-(4-phenylpiperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
CAS 852451-18-4C25H26N6O2
![1-(3-Chlorophenyl)-5-(2-oxo-2-(4-phenylpiperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one chemical structure, C23H21ClN6O2, CAS 887457-37-6](/s/MBBONFDKAFLFNZ-UHFFFAOYSA-N.svg)
1-(3-Chlorophenyl)-5-(2-oxo-2-(4-phenylpiperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
CAS 887457-37-6C23H21ClN6O2
![1-(2-Methylphenyl)-5-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C24H24N6O2, CAS 887456-85-1](/s/ILZNPAKDBCNXBE-UHFFFAOYSA-N.svg)
1-(2-Methylphenyl)-5-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one
CAS 887456-85-1C24H24N6O2
![1-(2,3-Dimethylphenyl)-5-(2-oxo-2-(4-phenylpiperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one chemical structure, C25H26N6O2, CAS 887458-40-4](/s/DGZITZJTRMWCKZ-UHFFFAOYSA-N.svg)
1-(2,3-Dimethylphenyl)-5-(2-oxo-2-(4-phenylpiperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
CAS 887458-40-4C25H26N6O2
![1-(2,4-Dimethylphenyl)-5-(2-oxo-2-(4-phenylpiperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one chemical structure, C25H26N6O2, CAS 887458-80-2](/s/SGSSVHCCLCXKPK-UHFFFAOYSA-N.svg)
1-(2,4-Dimethylphenyl)-5-(2-oxo-2-(4-phenylpiperazin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
CAS 887458-80-2C25H26N6O2
![1-(4-Fluorophenyl)-5-(2-(4-(4-fluorophenyl)piperazin-1-yl)-2-oxoethyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C23H20F2N6O2, CAS 1261001-00-6](/s/HLPLJUIWWAZMRQ-UHFFFAOYSA-N.svg)
1-(4-Fluorophenyl)-5-(2-(4-(4-fluorophenyl)piperazin-1-yl)-2-oxoethyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
CAS 1261001-00-6C23H20F2N6O2
![1-(2-Chlorophenyl)-5-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C23H21ClN6O2, CAS 1894995-45-9](/s/ZQWMQUNVSKDFFG-UHFFFAOYSA-N.svg)
1-(2-Chlorophenyl)-5-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one
CAS 1894995-45-9C23H21ClN6O2
![1-(4-Methoxyphenyl)-5-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C24H24N6O3, CAS 2309187-41-3](/s/IALRIQPCAQZPSY-UHFFFAOYSA-N.svg)
1-(4-Methoxyphenyl)-5-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one
CAS 2309187-41-3C24H24N6O3
![1-(4-Bromophenyl)-5-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C23H21BrN6O2, CAS 1894995-37-9](/s/VYIFTGLKSJAOJC-UHFFFAOYSA-N.svg)
1-(4-Bromophenyl)-5-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one
CAS 1894995-37-9C23H21BrN6O2
![1-(2-Chlorophenyl)-5-{2-[4-(4-methoxyphenyl)piperazin-1-yl]-2-oxoethyl}-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C24H23ClN6O3, CAS 1894995-46-0](/s/LJWVCANLKZLHST-UHFFFAOYSA-N.svg)
1-(2-Chlorophenyl)-5-{2-[4-(4-methoxyphenyl)piperazin-1-yl]-2-oxoethyl}-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one
CAS 1894995-46-0C24H23ClN6O3
![1-(4-Methoxyphenyl)-5-{2-[4-(4-methoxyphenyl)piperazin-1-yl]-2-oxoethyl}-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one chemical structure, C25H26N6O4, CAS 2549011-39-2](/s/MPFQCXPCSIONLM-UHFFFAOYSA-N.svg)
1-(4-Methoxyphenyl)-5-{2-[4-(4-methoxyphenyl)piperazin-1-yl]-2-oxoethyl}-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one
CAS 2549011-39-2C25H26N6O4