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Murcko scaffold

Ring system with 6 rings and 20 atoms

29 chemicals on CompoundList share this ring system.

Rings
6
Scaffold atoms
20
Chemicals
29
With full pages
8
Scaffold SMILES

O=C1C2C3C=CC(C4CC34)C2C(=O)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C2C3C=CC(C4CC34)C2C(=O)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 29 of 29 chemicals

2-(3-Chlorophenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione chemical structure, C17H14ClNO2, CAS 54962-38-8
2-(3-Chlorophenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione
CAS 54962-38-8C17H14ClNO2
2-(4-Bromophenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione chemical structure, C17H14BrNO2, CAS 54962-29-7
2-(4-Bromophenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione
CAS 54962-29-7C17H14BrNO2
2-(4-Methoxyphenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione chemical structure, C18H17NO3, CAS 54962-49-1
2-(4-Methoxyphenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione
CAS 54962-49-1C18H17NO3
2-(2,5-Dimethylphenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione chemical structure, C19H19NO2, CAS 342417-69-0
2-(2,5-Dimethylphenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione
CAS 342417-69-0C19H19NO2
Methyl 4-(1,3-dioxooctahydro-4,6-ethenocyclopropa[f]isoindol-2(1H)-yl)benzoate chemical structure, C19H17NO4, CAS 329325-54-4
Methyl 4-(1,3-dioxooctahydro-4,6-ethenocyclopropa[f]isoindol-2(1H)-yl)benzoate
CAS 329325-54-4C19H17NO4
2-(3-Methylphenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione chemical structure, C18H17NO2, CAS 432022-22-5
2-(3-Methylphenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione
CAS 432022-22-5C18H17NO2
2-(2-Chlorophenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione chemical structure, C17H14ClNO2, CAS 357623-63-3
2-(2-Chlorophenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione
CAS 357623-63-3C17H14ClNO2
3-(1,3-Dioxooctahydro-4,6-ethenocyclopropa[f]isoindol-2(1H)-yl)benzoic acid chemical structure, C18H15NO4, CAS 354812-58-1
3-(1,3-Dioxooctahydro-4,6-ethenocyclopropa[f]isoindol-2(1H)-yl)benzoic acid
CAS 354812-58-1C18H15NO4
2-(2-Chloro-5-nitrophenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione chemical structure, C17H13ClN2O4, CAS 354812-63-8
2-(2-Chloro-5-nitrophenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione
CAS 354812-63-8C17H13ClN2O4
2-(4-Chlorophenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione chemical structure, C17H14ClNO2, CAS 54962-31-1
2-(4-Chlorophenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione
CAS 54962-31-1C17H14ClNO2
4-(1,3-Dioxooctahydro-4,6-ethenocyclopropa[f]isoindol-2(1H)-yl)benzoic acid chemical structure, C18H15NO4, CAS 354812-64-9
4-(1,3-Dioxooctahydro-4,6-ethenocyclopropa[f]isoindol-2(1H)-yl)benzoic acid
CAS 354812-64-9C18H15NO4
2-(3,4-Dimethylphenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione chemical structure, C19H19NO2, CAS 322476-13-1
2-(3,4-Dimethylphenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione
CAS 322476-13-1C19H19NO2
2-(2,4-Dimethylphenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione chemical structure, C19H19NO2, CAS 357623-62-2
2-(2,4-Dimethylphenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione
CAS 357623-62-2C19H19NO2
2-(4-Methyl-3-nitrophenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione chemical structure, C18H16N2O4, CAS 354812-61-6
2-(4-Methyl-3-nitrophenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione
CAS 354812-61-6C18H16N2O4
2-(3-Acetylphenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione chemical structure, C19H17NO3, CAS 5677-74-7
2-(3-Acetylphenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione
CAS 5677-74-7C19H17NO3
2-(2,6-Dimethylphenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione chemical structure, C19H19NO2, CAS 438470-16-7
2-(2,6-Dimethylphenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione
CAS 438470-16-7C19H19NO2
2-(2-Ethylphenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione chemical structure, C19H19NO2, CAS 54962-42-4
2-(2-Ethylphenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione
CAS 54962-42-4C19H19NO2
2-(3-Hydroxyphenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione chemical structure, C17H15NO3, CAS 474377-80-5
2-(3-Hydroxyphenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione
CAS 474377-80-5C17H15NO3
2-(4-Bromo-2-ethylphenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione chemical structure, C19H18BrNO2, CAS 1212170-84-7
2-(4-Bromo-2-ethylphenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione
CAS 1212170-84-7C19H18BrNO2
2-[2-(Trifluoromethyl)phenyl]hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione chemical structure, C18H14F3NO2, CAS 54962-60-6
2-[2-(Trifluoromethyl)phenyl]hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione
CAS 54962-60-6C18H14F3NO2
2-(4-Bromo-5-chloro-2-methylphenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione chemical structure, C18H15BrClNO2, CAS 1005151-38-1
2-(4-Bromo-5-chloro-2-methylphenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione
CAS 1005151-38-1C18H15BrClNO2
2-(5-Chloro-2-hydroxyphenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione chemical structure, C17H14ClNO3, CAS 1212380-23-8
2-(5-Chloro-2-hydroxyphenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione
CAS 1212380-23-8C17H14ClNO3
2-(2,4-Dimethoxyphenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione chemical structure, C19H19NO4, CAS 1212330-70-5
2-(2,4-Dimethoxyphenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione
CAS 1212330-70-5C19H19NO4
2-(2-Ethoxyphenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione chemical structure, C19H19NO3, CAS 329325-52-2
2-(2-Ethoxyphenyl)hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione
CAS 329325-52-2C19H19NO3