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Murcko scaffold

Ring system with 2 rings and 22 atoms

21 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
22
Chemicals
21
With full pages
0
Scaffold SMILES

O=C(CNS(=O)(=O)c1ccccc1)NCCc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CNS(=O)(=O)c1ccccc1)NCCc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 21 of 21 chemicals

N(alpha)-tosylglycyl-3-amidinophenylalanine methyl ester chemical structure, C20H24N4O5S, CAS 133397-81-6
N(alpha)-tosylglycyl-3-amidinophenylalanine methyl ester
CAS 133397-81-6C20H24N4O5S
N(alpha)-tosyl-glycyl-3-amidinophenylalanine chemical structure, C19H22N4O5S, CAS 133397-82-7
N(alpha)-tosyl-glycyl-3-amidinophenylalanine
CAS 133397-82-7C19H22N4O5S
2-(2,5-Dimethylbenzenesulfonamido)-N-(2-phenylethyl)acetamide chemical structure, C18H22N2O3S, CAS 690644-36-1
2-(2,5-Dimethylbenzenesulfonamido)-N-(2-phenylethyl)acetamide
CAS 690644-36-1C18H22N2O3S
2-[(4-Chlorophenyl)sulfonyl-methylamino]-N-(2-phenylethyl)acetamide chemical structure, C17H19ClN2O3S, CAS 499113-21-2
2-[(4-Chlorophenyl)sulfonyl-methylamino]-N-(2-phenylethyl)acetamide
CAS 499113-21-2C17H19ClN2O3S
2-[Benzenesulfonyl(methyl)amino]-N-[2-(4-methoxyphenyl)ethyl]acetamide chemical structure, C18H22N2O4S, CAS 593262-14-7
2-[Benzenesulfonyl(methyl)amino]-N-[2-(4-methoxyphenyl)ethyl]acetamide
CAS 593262-14-7C18H22N2O4S
N~2~-methyl-N-(2-phenylethyl)-N~2~-(phenylsulfonyl)glycinamide chemical structure, C17H20N2O3S, CAS 593262-13-6
N~2~-methyl-N-(2-phenylethyl)-N~2~-(phenylsulfonyl)glycinamide
CAS 593262-13-6C17H20N2O3S
2-[Benzenesulfonyl(methyl)amino]-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide chemical structure, C19H24N2O5S, CAS 593262-15-8
2-[Benzenesulfonyl(methyl)amino]-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide
CAS 593262-15-8C19H24N2O5S
N~2~-[(4-chlorophenyl)sulfonyl]-N~2~-ethyl-N-(2-phenylethyl)glycinamide chemical structure, C18H21ClN2O3S, CAS 710979-70-7
N~2~-[(4-chlorophenyl)sulfonyl]-N~2~-ethyl-N-(2-phenylethyl)glycinamide
CAS 710979-70-7C18H21ClN2O3S
N~2~-ethyl-N~2~-[(4-methylphenyl)sulfonyl]-N-(2-phenylethyl)glycinamide chemical structure, C19H24N2O3S, CAS 714204-89-4
N~2~-ethyl-N~2~-[(4-methylphenyl)sulfonyl]-N-(2-phenylethyl)glycinamide
CAS 714204-89-4C19H24N2O3S
N~2~-ethyl-N-(2-phenylethyl)-N~2~-(phenylsulfonyl)glycinamide chemical structure, C18H22N2O3S, CAS 831242-49-0
N~2~-ethyl-N-(2-phenylethyl)-N~2~-(phenylsulfonyl)glycinamide
CAS 831242-49-0C18H22N2O3S
N-(2-Phenylethyl)-2-(2,3,5,6-tetramethylbenzenesulfonamido)acetamide chemical structure, C20H26N2O3S, CAS 690246-08-3
N-(2-Phenylethyl)-2-(2,3,5,6-tetramethylbenzenesulfonamido)acetamide
CAS 690246-08-3C20H26N2O3S
2-{[(3-Chloro-4-fluorophenyl)sulfonyl]amino}-N-(2-phenylethyl)acetamide chemical structure, C16H16ClFN2O3S, CAS 690647-39-3
2-{[(3-Chloro-4-fluorophenyl)sulfonyl]amino}-N-(2-phenylethyl)acetamide
CAS 690647-39-3C16H16ClFN2O3S
2-(3-Chloro-4-fluorobenzenesulfonamido)-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide chemical structure, C18H20ClFN2O5S, CAS 690647-45-1
2-(3-Chloro-4-fluorobenzenesulfonamido)-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide
CAS 690647-45-1C18H20ClFN2O5S
N-[2-(3,4-Dimethoxyphenyl)ethyl]-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide chemical structure, C20H26N2O5S, CAS 428504-42-1
N-[2-(3,4-Dimethoxyphenyl)ethyl]-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide
CAS 428504-42-1C20H26N2O5S
N-[2-(4-Methoxyphenyl)ethyl]-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide chemical structure, C19H24N2O4S, CAS 428837-78-9
N-[2-(4-Methoxyphenyl)ethyl]-2-[methyl-(4-methylphenyl)sulfonylamino]acetamide
CAS 428837-78-9C19H24N2O4S
Acetamide, 2-[[(4-methylphenyl)sulfonyl]amino]-N-(2-phenylethyl)- chemical structure, C17H20N2O3S, CAS 88422-75-7
Acetamide, 2-[[(4-methylphenyl)sulfonyl]amino]-N-(2-phenylethyl)-
CAS 88422-75-7C17H20N2O3S
Methyl 2-[(2-{[(4-bromophenyl)sulfonyl]amino}acetyl)amino]-3-phenylpropanoate chemical structure, C18H19BrN2O5S, CAS 1397003-32-5
Methyl 2-[(2-{[(4-bromophenyl)sulfonyl]amino}acetyl)amino]-3-phenylpropanoate
CAS 1397003-32-5C18H19BrN2O5S
Methyl 2-[(2-{[(4-fluorophenyl)sulfonyl]amino}acetyl)amino]-3-phenylpropanoate chemical structure, C18H19FN2O5S, CAS 1008465-58-4
Methyl 2-[(2-{[(4-fluorophenyl)sulfonyl]amino}acetyl)amino]-3-phenylpropanoate
CAS 1008465-58-4C18H19FN2O5S
N~2~-methyl-N~2~-[(4-methylphenyl)sulfonyl]-N-(2-phenylethyl)glycinamide chemical structure, C18H22N2O3S, CAS 501914-63-2
N~2~-methyl-N~2~-[(4-methylphenyl)sulfonyl]-N-(2-phenylethyl)glycinamide
CAS 501914-63-2C18H22N2O3S
2-(Benzenesulfonamido)-N-[2-(4-methoxyphenyl)ethyl]propanamide chemical structure, C18H22N2O4S, CAS 5337-24-6
2-(Benzenesulfonamido)-N-[2-(4-methoxyphenyl)ethyl]propanamide
CAS 5337-24-6C18H22N2O4S
L-Phenylalanine, 3-hydroxy-N-(phenylsulfonyl)-D-valyl-, methyl ester chemical structure, C21H26N2O6S, CAS 477191-20-1
L-Phenylalanine, 3-hydroxy-N-(phenylsulfonyl)-D-valyl-, methyl ester
CAS 477191-20-1C21H26N2O6S