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Murcko scaffold

Ring system with 4 rings and 25 atoms

38 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
38
With full pages
1
Scaffold SMILES

O=c1c(S(=O)(=O)c2ccccc2)c[nH]c2cc(N3CCCC3)ccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1c(S(=O)(=O)c2ccccc2)c[nH]c2cc(N3CCCC3)ccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 38 of 38 chemicals

6-Fluoro-1-methyl-3-(phenylsulfonyl)-7-(pyrrolidin-1-yl)quinolin-4(1H)-one chemical structure, C20H19FN2O3S, CAS 892757-28-7
6-Fluoro-1-methyl-3-(phenylsulfonyl)-7-(pyrrolidin-1-yl)quinolin-4(1H)-one
CAS 892757-28-7C20H19FN2O3S
3-((3,5-Dimethylphenyl)sulfonyl)-6-fluoro-1-methyl-7-(pyrrolidin-1-yl)quinolin-4(1H)-one chemical structure, C22H23FN2O3S, CAS 892787-83-6
3-((3,5-Dimethylphenyl)sulfonyl)-6-fluoro-1-methyl-7-(pyrrolidin-1-yl)quinolin-4(1H)-one
CAS 892787-83-6C22H23FN2O3S
6-Fluoro-1-propyl-7-(pyrrolidin-1-yl)-3-tosylquinolin-4(1H)-one chemical structure, C23H25FN2O3S, CAS 892762-98-0
6-Fluoro-1-propyl-7-(pyrrolidin-1-yl)-3-tosylquinolin-4(1H)-one
CAS 892762-98-0C23H25FN2O3S
3-(3,5-Dimethylbenzenesulfonyl)-1-ethyl-6-fluoro-7-(pyrrolidin-1-yl)-1,4-dihydroquinolin-4-one chemical structure, C23H25FN2O3S, CAS 892788-39-5
3-(3,5-Dimethylbenzenesulfonyl)-1-ethyl-6-fluoro-7-(pyrrolidin-1-yl)-1,4-dihydroquinolin-4-one
CAS 892788-39-5C23H25FN2O3S
3-((3-Chlorophenyl)sulfonyl)-6-fluoro-1-propyl-7-(pyrrolidin-1-yl)quinolin-4(1H)-one chemical structure, C22H22ClFN2O3S, CAS 892757-69-6
3-((3-Chlorophenyl)sulfonyl)-6-fluoro-1-propyl-7-(pyrrolidin-1-yl)quinolin-4(1H)-one
CAS 892757-69-6C22H22ClFN2O3S
3-(4-Ethylbenzenesulfonyl)-6-fluoro-1-methyl-7-(pyrrolidin-1-yl)-1,4-dihydroquinolin-4-one chemical structure, C22H23FN2O3S, CAS 892768-24-0
3-(4-Ethylbenzenesulfonyl)-6-fluoro-1-methyl-7-(pyrrolidin-1-yl)-1,4-dihydroquinolin-4-one
CAS 892768-24-0C22H23FN2O3S
1-Butyl-6-fluoro-3-((4-methoxyphenyl)sulfonyl)-7-(pyrrolidin-1-yl)quinolin-4(1H)-one chemical structure, C24H27FN2O4S, CAS 892774-01-5
1-Butyl-6-fluoro-3-((4-methoxyphenyl)sulfonyl)-7-(pyrrolidin-1-yl)quinolin-4(1H)-one
CAS 892774-01-5C24H27FN2O4S
3-((4-Chlorophenyl)sulfonyl)-6-fluoro-1-methyl-7-(pyrrolidin-1-yl)quinolin-4(1H)-one chemical structure, C20H18ClFN2O3S, CAS 892774-73-1
3-((4-Chlorophenyl)sulfonyl)-6-fluoro-1-methyl-7-(pyrrolidin-1-yl)quinolin-4(1H)-one
CAS 892774-73-1C20H18ClFN2O3S
3-((2,4-Dimethylphenyl)sulfonyl)-6-fluoro-1-methyl-7-(pyrrolidin-1-yl)quinolin-4(1H)-one chemical structure, C22H23FN2O3S, CAS 892777-76-3
3-((2,4-Dimethylphenyl)sulfonyl)-6-fluoro-1-methyl-7-(pyrrolidin-1-yl)quinolin-4(1H)-one
CAS 892777-76-3C22H23FN2O3S
3-((2,4-Dimethylphenyl)sulfonyl)-1-ethyl-6-fluoro-7-(pyrrolidin-1-yl)quinolin-4(1H)-one chemical structure, C23H25FN2O3S, CAS 892778-63-1
3-((2,4-Dimethylphenyl)sulfonyl)-1-ethyl-6-fluoro-7-(pyrrolidin-1-yl)quinolin-4(1H)-one
CAS 892778-63-1C23H25FN2O3S
3-(Benzenesulfonyl)-6-fluoro-1-propyl-7-(pyrrolidin-1-yl)-1,4-dihydroquinolin-4-one chemical structure, C22H23FN2O3S, CAS 892758-65-5
3-(Benzenesulfonyl)-6-fluoro-1-propyl-7-(pyrrolidin-1-yl)-1,4-dihydroquinolin-4-one
CAS 892758-65-5C22H23FN2O3S
1-Ethyl-6-fluoro-7-(pyrrolidin-1-yl)-3-tosylquinolin-4(1H)-one chemical structure, C22H23FN2O3S, CAS 892762-32-2
1-Ethyl-6-fluoro-7-(pyrrolidin-1-yl)-3-tosylquinolin-4(1H)-one
CAS 892762-32-2C22H23FN2O3S
6-Fluoro-1-methyl-7-(pyrrolidin-1-yl)-3-tosylquinolin-4(1H)-one chemical structure, C21H21FN2O3S, CAS 892761-56-7
6-Fluoro-1-methyl-7-(pyrrolidin-1-yl)-3-tosylquinolin-4(1H)-one
CAS 892761-56-7C21H21FN2O3S
6-Fluoro-3-((4-methoxyphenyl)sulfonyl)-1-propyl-7-(pyrrolidin-1-yl)quinolin-4(1H)-one chemical structure, C23H25FN2O4S, CAS 892773-38-5
6-Fluoro-3-((4-methoxyphenyl)sulfonyl)-1-propyl-7-(pyrrolidin-1-yl)quinolin-4(1H)-one
CAS 892773-38-5C23H25FN2O4S
1-Butyl-6-fluoro-7-(pyrrolidin-1-yl)-3-tosylquinolin-4(1H)-one chemical structure, C24H27FN2O3S, CAS 892763-61-0
1-Butyl-6-fluoro-7-(pyrrolidin-1-yl)-3-tosylquinolin-4(1H)-one
CAS 892763-61-0C24H27FN2O3S
3-(2,5-Dimethylbenzenesulfonyl)-6-fluoro-1-methyl-7-(pyrrolidin-1-yl)-1,4-dihydroquinolin-4-one chemical structure, C22H23FN2O3S, CAS 892779-61-2
3-(2,5-Dimethylbenzenesulfonyl)-6-fluoro-1-methyl-7-(pyrrolidin-1-yl)-1,4-dihydroquinolin-4-one
CAS 892779-61-2C22H23FN2O3S
3-(2,5-Dimethylbenzenesulfonyl)-1-ethyl-6-fluoro-7-(pyrrolidin-1-yl)-1,4-dihydroquinolin-4-one chemical structure, C23H25FN2O3S, CAS 892780-44-8
3-(2,5-Dimethylbenzenesulfonyl)-1-ethyl-6-fluoro-7-(pyrrolidin-1-yl)-1,4-dihydroquinolin-4-one
CAS 892780-44-8C23H25FN2O3S
3-((2,5-Dimethylphenyl)sulfonyl)-6-fluoro-1-propyl-7-(pyrrolidin-1-yl)quinolin-4(1H)-one chemical structure, C24H27FN2O3S, CAS 892781-19-0
3-((2,5-Dimethylphenyl)sulfonyl)-6-fluoro-1-propyl-7-(pyrrolidin-1-yl)quinolin-4(1H)-one
CAS 892781-19-0C24H27FN2O3S
1-Butyl-3-(2,5-dimethylbenzenesulfonyl)-6-fluoro-7-(pyrrolidin-1-yl)-1,4-dihydroquinolin-4-one chemical structure, C25H29FN2O3S, CAS 892782-07-9
1-Butyl-3-(2,5-dimethylbenzenesulfonyl)-6-fluoro-7-(pyrrolidin-1-yl)-1,4-dihydroquinolin-4-one
CAS 892782-07-9C25H29FN2O3S
1-Butyl-6-fluoro-3-(phenylsulfonyl)-7-(pyrrolidin-1-yl)quinolin-4(1H)-one chemical structure, C23H25FN2O3S, CAS 892759-28-3
1-Butyl-6-fluoro-3-(phenylsulfonyl)-7-(pyrrolidin-1-yl)quinolin-4(1H)-one
CAS 892759-28-3C23H25FN2O3S
3-(3,4-Dimethylbenzenesulfonyl)-1-ethyl-6-fluoro-7-(pyrrolidin-1-yl)-1,4-dihydroquinolin-4-one chemical structure, C23H25FN2O3S, CAS 892765-84-3
3-(3,4-Dimethylbenzenesulfonyl)-1-ethyl-6-fluoro-7-(pyrrolidin-1-yl)-1,4-dihydroquinolin-4-one
CAS 892765-84-3C23H25FN2O3S
3-(3,4-Dimethylbenzenesulfonyl)-6-fluoro-1-propyl-7-(pyrrolidin-1-yl)-1,4-dihydroquinolin-4-one chemical structure, C24H27FN2O3S, CAS 892766-64-2
3-(3,4-Dimethylbenzenesulfonyl)-6-fluoro-1-propyl-7-(pyrrolidin-1-yl)-1,4-dihydroquinolin-4-one
CAS 892766-64-2C24H27FN2O3S
1-Butyl-3-((3,4-dimethylphenyl)sulfonyl)-6-fluoro-7-(pyrrolidin-1-yl)quinolin-4(1H)-one chemical structure, C25H29FN2O3S, CAS 892767-36-1
1-Butyl-3-((3,4-dimethylphenyl)sulfonyl)-6-fluoro-7-(pyrrolidin-1-yl)quinolin-4(1H)-one
CAS 892767-36-1C25H29FN2O3S
1-Ethyl-3-(4-ethylbenzenesulfonyl)-6-fluoro-7-(pyrrolidin-1-yl)-1,4-dihydroquinolin-4-one chemical structure, C23H25FN2O3S, CAS 892769-13-0
1-Ethyl-3-(4-ethylbenzenesulfonyl)-6-fluoro-7-(pyrrolidin-1-yl)-1,4-dihydroquinolin-4-one
CAS 892769-13-0C23H25FN2O3S