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Murcko scaffold

Ring system with 4 rings and 22 atoms

13 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
13
With full pages
4
Scaffold SMILES

O=C(CC1C(=O)Nc2ccccc21)c1ccc2c(c1)OCO2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CC1C(=O)Nc2ccccc21)c1ccc2c(c1)OCO2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

3-[2-(1,3-Benzodioxol-5-yl)-2-oxoethyl]-5-bromo-3-hydroxy-1,3-dihydro-2H-indol-2-one chemical structure, C17H12BrNO5, CAS 258264-62-9
3-[2-(1,3-Benzodioxol-5-yl)-2-oxoethyl]-5-bromo-3-hydroxy-1,3-dihydro-2H-indol-2-one
CAS 258264-62-9C17H12BrNO5
3-[2-(1,3-Benzodioxol-5-yl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one chemical structure, C17H13NO5, CAS 296793-36-7
3-[2-(1,3-Benzodioxol-5-yl)-2-oxoethyl]-3-hydroxy-1,3-dihydro-2H-indol-2-one
CAS 296793-36-7C17H13NO5
3-[2-(1,3-Benzodioxol-5-yl)-2-oxoethyl]-3-hydroxy-1-methyl-1,3-dihydro-2H-indol-2-one chemical structure, C18H15NO5, CAS 312504-23-7
3-[2-(1,3-Benzodioxol-5-yl)-2-oxoethyl]-3-hydroxy-1-methyl-1,3-dihydro-2H-indol-2-one
CAS 312504-23-7C18H15NO5
3-[2-(1,3-Benzodioxol-5-yl)-2-oxoethyl]-1-ethyl-3-hydroxyindol-2-one chemical structure, C19H17NO5, CAS 632292-60-5
3-[2-(1,3-Benzodioxol-5-yl)-2-oxoethyl]-1-ethyl-3-hydroxyindol-2-one
CAS 632292-60-5C19H17NO5
3-[2-(1,3-Benzodioxol-5-yl)-2-oxoethyl]-3-hydroxy-5-methyl-1,3-dihydro-2H-indol-2-one chemical structure, C18H15NO5, CAS 632293-20-0
3-[2-(1,3-Benzodioxol-5-yl)-2-oxoethyl]-3-hydroxy-5-methyl-1,3-dihydro-2H-indol-2-one
CAS 632293-20-0C18H15NO5
Ethyl {3-[2-(1,3-benzodioxol-5-yl)-2-oxoethyl]-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-1-yl}acetate chemical structure, C21H19NO7, CAS 688037-44-7
Ethyl {3-[2-(1,3-benzodioxol-5-yl)-2-oxoethyl]-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-1-yl}acetate
CAS 688037-44-7C21H19NO7
3-[2-(1,3-Benzodioxol-5-yl)-2-oxoethyl]-5-chloro-3-hydroxy-1-methylindol-2-one chemical structure, C18H14ClNO5, CAS 838896-11-0
3-[2-(1,3-Benzodioxol-5-yl)-2-oxoethyl]-5-chloro-3-hydroxy-1-methylindol-2-one
CAS 838896-11-0C18H14ClNO5
3-[2-(1,3-Benzodioxol-5-yl)-2-oxoethyl]-5-chloro-3-hydroxy-1H-indol-2-one chemical structure, C17H12ClNO5, CAS 842115-46-2
3-[2-(1,3-Benzodioxol-5-yl)-2-oxoethyl]-5-chloro-3-hydroxy-1H-indol-2-one
CAS 842115-46-2C17H12ClNO5
3-[2-(1,3-Benzodioxol-5-yl)-2-oxoethyl]-3-hydroxy-1-propyl-1,3-dihydro-2H-indol-2-one chemical structure, C20H19NO5, CAS 688037-08-3
3-[2-(1,3-Benzodioxol-5-yl)-2-oxoethyl]-3-hydroxy-1-propyl-1,3-dihydro-2H-indol-2-one
CAS 688037-08-3C20H19NO5
3-[2-(1,3-Benzodioxol-5-yl)-2-oxoethyl]-5-bromo-3-hydroxy-1-propyl-1,3-dihydro-2H-indol-2-one chemical structure, C20H18BrNO5, CAS 688038-50-8
3-[2-(1,3-Benzodioxol-5-yl)-2-oxoethyl]-5-bromo-3-hydroxy-1-propyl-1,3-dihydro-2H-indol-2-one
CAS 688038-50-8C20H18BrNO5
3-[2-(1,3-Benzodioxol-5-yl)-2-oxoethyl]-5-bromo-3-hydroxy-1-methyl-1,3-dihydro-2H-indol-2-one chemical structure, C18H14BrNO5, CAS 689768-63-6
3-[2-(1,3-Benzodioxol-5-yl)-2-oxoethyl]-5-bromo-3-hydroxy-1-methyl-1,3-dihydro-2H-indol-2-one
CAS 689768-63-6C18H14BrNO5
3-[2-(1,3-Benzodioxol-5-yl)-2-oxoethyl]-3-hydroxy-1-propan-2-ylindol-2-one chemical structure, C20H19NO5, CAS 688038-40-6
3-[2-(1,3-Benzodioxol-5-yl)-2-oxoethyl]-3-hydroxy-1-propan-2-ylindol-2-one
CAS 688038-40-6C20H19NO5
3-[2-(1,3-Benzodioxol-5-yl)-2-oxoethyl]-5-ethyl-1,3-dihydro-3-hydroxy-2H-indol-2-one chemical structure, C19H17NO5, CAS 893766-55-7
3-[2-(1,3-Benzodioxol-5-yl)-2-oxoethyl]-5-ethyl-1,3-dihydro-3-hydroxy-2H-indol-2-one
CAS 893766-55-7C19H17NO5