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Murcko scaffold

2-[(2-Oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]-N-(1,3-thiazol-2-yl)acetamide scaffold

13 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 20
Chemicals: 13
With full pages: 3

Scaffold SMILES

O=C(CSc1nc(=O)[nH]c2c1CCC2)Nc1nccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 2-[(2-Oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]-N-(1,3-thiazol-2-yl)acetamide page

Murcko scaffold O=C(CSc1nc(=O)[nH]c2c1CCC2)Nc1nccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

2-[(2-Oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]-N-(1,3-thiazol-2-yl)acetamide chemical structure, C12H12N4O2S2, CAS 1001519-74-9

2-[(2-Oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-yl)sulfanyl]-N-(1,3-thiazol-2-yl)acetamide

CAS 1001519-74-9C₁₂H₁₂N₄O₂S₂

N-(4-Methylthiazol-2-yl)-2-((2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide chemical structure, C13H14N4O2S2, CAS 896365-94-9

N-(4-Methylthiazol-2-yl)-2-((2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide

CAS 896365-94-9C₁₃H₁₄N₄O₂S₂

2-((1-(2-(Dimethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C16H21N5O2S2, CAS 946270-13-9

2-((1-(2-(Dimethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(thiazol-2-yl)acetamide

CAS 946270-13-9C₁₆H₂₁N₅O₂S₂

2-((1-(2-(Dimethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(4-methylthiazol-2-yl)acetamide chemical structure, C17H23N5O2S2, CAS 896366-12-4

2-((1-(2-(Dimethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(4-methylthiazol-2-yl)acetamide

CAS 896366-12-4C₁₇H₂₃N₅O₂S₂

2-[[1-[3-(Dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]-N-(1,3-thiazol-2-yl)acetamide chemical structure, C17H23N5O2S2, CAS 898434-39-4

2-[[1-[3-(Dimethylamino)propyl]-2-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]sulfanyl]-N-(1,3-thiazol-2-yl)acetamide

CAS 898434-39-4C₁₇H₂₃N₅O₂S₂

2-((1-(3-(Dimethylamino)propyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(4-methylthiazol-2-yl)acetamide chemical structure, C18H25N5O2S2, CAS 898460-05-4

2-((1-(3-(Dimethylamino)propyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(4-methylthiazol-2-yl)acetamide

CAS 898460-05-4C₁₈H₂₅N₅O₂S₂

Ethyl 2-(2-(2-((2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamido)thiazol-4-yl)acetate chemical structure, C16H18N4O4S2, CAS 898450-08-3

Ethyl 2-(2-(2-((2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamido)thiazol-4-yl)acetate

CAS 898450-08-3C₁₆H₁₈N₄O₄S₂

2-((1-(2-(Diethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C18H25N5O2S2, CAS 898434-02-1

2-((1-(2-(Diethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(thiazol-2-yl)acetamide

CAS 898434-02-1C₁₈H₂₅N₅O₂S₂

2-((1-(2-(Diethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(4-methylthiazol-2-yl)acetamide chemical structure, C19H27N5O2S2, CAS 898459-64-8

2-((1-(2-(Diethylamino)ethyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(4-methylthiazol-2-yl)acetamide

CAS 898459-64-8C₁₉H₂₇N₅O₂S₂

2-((1-(3-(Diethylamino)propyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C19H27N5O2S2, CAS 898460-49-6

2-((1-(3-(Diethylamino)propyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(thiazol-2-yl)acetamide

CAS 898460-49-6C₁₉H₂₇N₅O₂S₂

2-((1-(3-(Diethylamino)propyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(4-methylthiazol-2-yl)acetamide chemical structure, C20H29N5O2S2, CAS 898434-83-8

2-((1-(3-(Diethylamino)propyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(4-methylthiazol-2-yl)acetamide

CAS 898434-83-8C₂₀H₂₉N₅O₂S₂

2-((1-(3-Hydroxypropyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C15H18N4O3S2, CAS 899743-20-5

2-((1-(3-Hydroxypropyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(thiazol-2-yl)acetamide

CAS 899743-20-5C₁₅H₁₈N₄O₃S₂

2-((1-(3-Hydroxypropyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(4-methylthiazol-2-yl)acetamide chemical structure, C16H20N4O3S2, CAS 899973-88-7

2-((1-(3-Hydroxypropyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(4-methylthiazol-2-yl)acetamide

CAS 899973-88-7C₁₆H₂₀N₄O₃S₂