Murcko scaffold
2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-((tetrahydrofuran-2-yl)methyl)acetamide scaffold
16 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 27
- Chemicals
- 16
- With full pages
- 11
Scaffold SMILES
O=C(CSc1nc2c(c(=O)n1-c1ccccc1)SCC2)NCC1CCCO1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 16 of 16 chemicals
![2-[[3-(4-Chlorophenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-(oxolan-2-ylmethyl)acetamide chemical structure, C19H20ClN3O3S2, CAS 687563-84-4](/s/SGWJMKCMBVABEB-UHFFFAOYSA-N.svg)
2-[[3-(4-Chlorophenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-(oxolan-2-ylmethyl)acetamide
CAS 687563-84-4C19H20ClN3O3S2
![2-[[3-(4-Methylphenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-(oxolan-2-ylmethyl)acetamide chemical structure, C20H23N3O3S2, CAS 686771-49-3](/s/HXSZNSDREFEETB-UHFFFAOYSA-N.svg)
2-[[3-(4-Methylphenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-(oxolan-2-ylmethyl)acetamide
CAS 686771-49-3C20H23N3O3S2
![2-[[3-(4-Fluorophenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-(oxolan-2-ylmethyl)acetamide chemical structure, C19H20FN3O3S2, CAS 687561-57-5](/s/SGQCUSQOARMTKG-UHFFFAOYSA-N.svg)
2-[[3-(4-Fluorophenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-(oxolan-2-ylmethyl)acetamide
CAS 687561-57-5C19H20FN3O3S2
![2-((3-(4-Bromophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-((tetrahydrofuran-2-yl)methyl)acetamide chemical structure, C19H20BrN3O3S2, CAS 687566-29-6](/s/ONYDMMLXODRSLU-UHFFFAOYSA-N.svg)
2-((3-(4-Bromophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-((tetrahydrofuran-2-yl)methyl)acetamide
CAS 687566-29-6C19H20BrN3O3S2
![2-[[3-(4-Nitrophenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-(oxolan-2-ylmethyl)acetamide chemical structure, C19H20N4O5S2, CAS 687568-59-8](/s/QEQGEFWZMPYOIT-UHFFFAOYSA-N.svg)
2-[[3-(4-Nitrophenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-(oxolan-2-ylmethyl)acetamide
CAS 687568-59-8C19H20N4O5S2
![2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-((tetrahydrofuran-2-yl)methyl)acetamide chemical structure, C19H21N3O3S2, CAS 686770-59-2](/s/DEOJHCDSGPVSBY-UHFFFAOYSA-N.svg)
2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-((tetrahydrofuran-2-yl)methyl)acetamide
CAS 686770-59-2C19H21N3O3S2
![2-[[3-(4-Methoxyphenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-(oxolan-2-ylmethyl)acetamide chemical structure, C20H23N3O4S2, CAS 850915-61-6](/s/SIGMUHNPSBJXJV-UHFFFAOYSA-N.svg)
2-[[3-(4-Methoxyphenyl)-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl]sulfanyl]-N-(oxolan-2-ylmethyl)acetamide
CAS 850915-61-6C20H23N3O4S2
![2-((3-(3,5-Dimethylphenyl)-6-methyl-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-((tetrahydrofuran-2-yl)methyl)acetamide chemical structure, C22H27N3O3S2, CAS 896677-09-1](/s/NKDVWIVUQSSYCZ-UHFFFAOYSA-N.svg)
2-((3-(3,5-Dimethylphenyl)-6-methyl-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-((tetrahydrofuran-2-yl)methyl)acetamide
CAS 896677-09-1C22H27N3O3S2
![2-((3-(4-Ethoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-((tetrahydrofuran-2-yl)methyl)acetamide chemical structure, C21H25N3O4S2, CAS 686772-46-3](/s/VHZQGSWRZPLMLT-UHFFFAOYSA-N.svg)
2-((3-(4-Ethoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-((tetrahydrofuran-2-yl)methyl)acetamide
CAS 686772-46-3C21H25N3O4S2
![2-((6-Methyl-4-oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-((tetrahydrofuran-2-yl)methyl)acetamide chemical structure, C20H23N3O3S2, CAS 905686-65-9](/s/NYAUCRQOUKAPPT-UHFFFAOYSA-N.svg)
2-((6-Methyl-4-oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-((tetrahydrofuran-2-yl)methyl)acetamide
CAS 905686-65-9C20H23N3O3S2
![2-((3-(4-Methoxyphenyl)-6-methyl-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-((tetrahydrofuran-2-yl)methyl)acetamide chemical structure, C21H25N3O4S2, CAS 862825-50-1](/s/YPAKBYBSPKASDV-UHFFFAOYSA-N.svg)
2-((3-(4-Methoxyphenyl)-6-methyl-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-((tetrahydrofuran-2-yl)methyl)acetamide
CAS 862825-50-1C21H25N3O4S2
![2-((3-(4-Fluorophenyl)-6-methyl-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-((tetrahydrofuran-2-yl)methyl)acetamide chemical structure, C20H22FN3O3S2, CAS 862825-57-8](/s/CTKCQBVXKMIEOW-UHFFFAOYSA-N.svg)
2-((3-(4-Fluorophenyl)-6-methyl-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-((tetrahydrofuran-2-yl)methyl)acetamide
CAS 862825-57-8C20H22FN3O3S2
![2-((3-(3,5-Dimethylphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-((tetrahydrofuran-2-yl)methyl)acetamide chemical structure, C21H25N3O3S2, CAS 877653-86-6](/s/IXAKEORFVDVIAW-UHFFFAOYSA-N.svg)
2-((3-(3,5-Dimethylphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-((tetrahydrofuran-2-yl)methyl)acetamide
CAS 877653-86-6C21H25N3O3S2
![2-((4-Oxo-3-(4-(trifluoromethoxy)phenyl)-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-((tetrahydrofuran-2-yl)methyl)acetamide chemical structure, C20H20F3N3O4S2, CAS 877654-51-8](/s/CEMSBVWXBHJSRY-UHFFFAOYSA-N.svg)
2-((4-Oxo-3-(4-(trifluoromethoxy)phenyl)-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-((tetrahydrofuran-2-yl)methyl)acetamide
CAS 877654-51-8C20H20F3N3O4S2
![2-{[3-(3-Methoxyphenyl)-4-oxo-3H,4H,6H,7H-thieno[3,2-d]pyrimidin-2-yl]sulfanyl}-N-[(oxolan-2-yl)methyl]acetamide chemical structure, C20H23N3O4S2, CAS 877655-61-3](/s/OBXOJXYWNSDAPJ-UHFFFAOYSA-N.svg)
2-{[3-(3-Methoxyphenyl)-4-oxo-3H,4H,6H,7H-thieno[3,2-d]pyrimidin-2-yl]sulfanyl}-N-[(oxolan-2-yl)methyl]acetamide
CAS 877655-61-3C20H23N3O4S2
![2-((3-(3,4-Dimethoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-((tetrahydrofuran-2-yl)methyl)acetamide chemical structure, C21H25N3O5S2, CAS 877656-03-6](/s/IEYZBBPOOXBBCW-UHFFFAOYSA-N.svg)
2-((3-(3,4-Dimethoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-((tetrahydrofuran-2-yl)methyl)acetamide
CAS 877656-03-6C21H25N3O5S2
Related scaffolds
Same ring framework with different atoms or bond orders
