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Murcko scaffold

Ring system with 3 rings and 24 atoms

13 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
24
Chemicals
13
With full pages
1
Scaffold SMILES

O=C(NC(CN1CCCC1)c1ccccc1)OCc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NC(CN1CCCC1)c1ccccc1)OCc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

(2's,3s)-[2-(3-Hydroxypyrrolidin-1-yl)-1-phenylethyl]methylcarbamic acid benzyl ester chemical structure, C21H26N2O3, CAS 672310-23-5
(2's,3s)-[2-(3-Hydroxypyrrolidin-1-yl)-1-phenylethyl]methylcarbamic acid benzyl ester
CAS 672310-23-5C21H26N2O3
Benzyl (1-(2-chlorophenyl)-2-(pyrrolidin-1-yl)ethyl)(methyl)carbamate chemical structure, C21H25ClN2O2, CAS 675602-67-2
Benzyl (1-(2-chlorophenyl)-2-(pyrrolidin-1-yl)ethyl)(methyl)carbamate
CAS 675602-67-2C21H25ClN2O2
Benzyl (1-(3-chlorophenyl)-2-(pyrrolidin-1-yl)ethyl)(methyl)carbamate chemical structure, C21H25ClN2O2, CAS 675602-68-3
Benzyl (1-(3-chlorophenyl)-2-(pyrrolidin-1-yl)ethyl)(methyl)carbamate
CAS 675602-68-3C21H25ClN2O2
Carbamic acid, [1-(4-chlorophenyl)-2-(1-pyrrolidinyl)ethyl]methyl-, phenylmethyl ester chemical structure, C21H25ClN2O2, CAS 675602-70-7
Carbamic acid, [1-(4-chlorophenyl)-2-(1-pyrrolidinyl)ethyl]methyl-, phenylmethyl ester
CAS 675602-70-7C21H25ClN2O2
1-Pyrrolidin-2-(4'-methylphenyl)-2-(N-Cbz-N-methyl)amino-ethane chemical structure, C22H28N2O2, CAS 675602-72-9
1-Pyrrolidin-2-(4'-methylphenyl)-2-(N-Cbz-N-methyl)amino-ethane
CAS 675602-72-9C22H28N2O2
Benzyl methyl(2-(pyrrolidin-1-yl)-1-(3-(trifluoromethyl)phenyl)ethyl)carbamate chemical structure, C22H25F3N2O2, CAS 675602-69-4
Benzyl methyl(2-(pyrrolidin-1-yl)-1-(3-(trifluoromethyl)phenyl)ethyl)carbamate
CAS 675602-69-4C22H25F3N2O2
Benzyl methyl(2-(pyrrolidin-1-yl)-1-(4-(trifluoromethyl)phenyl)ethyl)carbamate chemical structure, C22H25F3N2O2, CAS 675602-73-0
Benzyl methyl(2-(pyrrolidin-1-yl)-1-(4-(trifluoromethyl)phenyl)ethyl)carbamate
CAS 675602-73-0C22H25F3N2O2
Benzyl N-[1-(3,5-dichlorophenyl)-2-pyrrolidin-1-ylethyl]-N-methylcarbamate chemical structure, C21H24Cl2N2O2, CAS 886362-13-6
Benzyl N-[1-(3,5-dichlorophenyl)-2-pyrrolidin-1-ylethyl]-N-methylcarbamate
CAS 886362-13-6C21H24Cl2N2O2
Benzyl ((S)-1-(4-fluorophenyl)-2-((S)-3-hydroxypyrrolidin-1-yl)ethyl)(methyl)carbamate chemical structure, C21H25FN2O3, CAS 1263078-23-4
Benzyl ((S)-1-(4-fluorophenyl)-2-((S)-3-hydroxypyrrolidin-1-yl)ethyl)(methyl)carbamate
CAS 1263078-23-4C21H25FN2O3
1-Pyrrolidin-2-(4'-trifluoromethylphenyl)-2-(N-Cbz-N-methyl)amino-ethane HCl chemical structure, C22H26ClF3N2O2, CAS 1159826-10-4
1-Pyrrolidin-2-(4'-trifluoromethylphenyl)-2-(N-Cbz-N-methyl)amino-ethane HCl
CAS 1159826-10-4C22H26ClF3N2O2
1-Pyrrolidin-2-(2'-chlorophenyl)-2-(N-Cbz-N-methyl)amino-ethane HCl chemical structure, C21H26Cl2N2O2, CAS 1159825-67-8
1-Pyrrolidin-2-(2'-chlorophenyl)-2-(N-Cbz-N-methyl)amino-ethane HCl
CAS 1159825-67-8C21H26Cl2N2O2
1-Pyrrolidin-2-(4'-chlorophenyl)-2-(N-cbz-N-methyl)amino-ethane hcl chemical structure, C21H26Cl2N2O2, CAS 1159825-59-8
1-Pyrrolidin-2-(4'-chlorophenyl)-2-(N-cbz-N-methyl)amino-ethane hcl
CAS 1159825-59-8C21H26Cl2N2O2
1-Pyrrolidin-2-(3'-chlorophenyl)-2-(N-Cbz-N-methyl)amino-ethane HCl chemical structure, C21H26Cl2N2O2, CAS 1159825-52-1
1-Pyrrolidin-2-(3'-chlorophenyl)-2-(N-Cbz-N-methyl)amino-ethane HCl
CAS 1159825-52-1C21H26Cl2N2O2