CompoundList
Sign in
Murcko scaffold

Ring system with 2 rings and 16 atoms

11 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
16
Chemicals
11
With full pages
5
Scaffold SMILES

O=C1CN(C(=O)Nc2ccccc2)CCN1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CN(C(=O)Nc2ccccc2)CCN1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 11 of 11 chemicals

(3-Oxo-1-phenylcarbamoyl-piperazin-2-yl)-acetic acid methyl ester chemical structure, C14H17N3O4, CAS 1042134-00-8
(3-Oxo-1-phenylcarbamoyl-piperazin-2-yl)-acetic acid methyl ester
CAS 1042134-00-8C14H17N3O4
[1-(4-Chloro-phenylcarbamoyl)-3-oxo-piperazin-2-yl]-acetic acid methyl ester chemical structure, C14H16ClN3O4, CAS 1008865-28-8
[1-(4-Chloro-phenylcarbamoyl)-3-oxo-piperazin-2-yl]-acetic acid methyl ester
CAS 1008865-28-8C14H16ClN3O4
Methyl 2-{1-[N-(3,4-dichlorophenyl)carbamoyl]-3-oxopiperazin-2-yl}acetate chemical structure, C14H15Cl2N3O4, CAS 1008930-16-2
Methyl 2-{1-[N-(3,4-dichlorophenyl)carbamoyl]-3-oxopiperazin-2-yl}acetate
CAS 1008930-16-2C14H15Cl2N3O4
Methyl 2-{1-[N-(3-chlorophenyl)carbamoyl]-3-oxopiperazin-2-yl}acetate chemical structure, C14H16ClN3O4, CAS 1008462-54-1
Methyl 2-{1-[N-(3-chlorophenyl)carbamoyl]-3-oxopiperazin-2-yl}acetate
CAS 1008462-54-1C14H16ClN3O4
Ethyl [1-(anilinocarbonyl)-3-oxo-2-piperazinyl]acetate chemical structure, C15H19N3O4, CAS 61155-21-3
Ethyl [1-(anilinocarbonyl)-3-oxo-2-piperazinyl]acetate
CAS 61155-21-3C15H19N3O4
Ethyl 2-{1-[(4-chloroanilino)carbonyl]-3-oxo-2-piperazinyl}acetate chemical structure, C15H18ClN3O4, CAS 1007932-18-4
Ethyl 2-{1-[(4-chloroanilino)carbonyl]-3-oxo-2-piperazinyl}acetate
CAS 1007932-18-4C15H18ClN3O4
Methyl {1-[(4-methoxyphenyl)carbamoyl]-3-oxopiperazin-2-yl}acetate chemical structure, C15H19N3O5, CAS 1008981-75-6
Methyl {1-[(4-methoxyphenyl)carbamoyl]-3-oxopiperazin-2-yl}acetate
CAS 1008981-75-6C15H19N3O5
N-(4-Nitrophenyl)-3-oxopiperazine-1-carboxamide chemical structure, C11H12N4O4, CAS 941166-04-7
N-(4-Nitrophenyl)-3-oxopiperazine-1-carboxamide
CAS 941166-04-7C11H12N4O4
N-(2,6-Difluorophenyl)-3-oxopiperazine-1-carboxamide chemical structure, C11H11F2N3O2, CAS 2327286-97-3
N-(2,6-Difluorophenyl)-3-oxopiperazine-1-carboxamide
CAS 2327286-97-3C11H11F2N3O2
2-(3-Oxopiperazine-1-carboxamido)benzoic acid chemical structure, C12H13N3O4, CAS 1219560-26-5
2-(3-Oxopiperazine-1-carboxamido)benzoic acid
CAS 1219560-26-5C12H13N3O4
3-Oxo-N-[2-(trifluoromethyl)phenyl]piperazine-1-carboxamide chemical structure, C12H12F3N3O2, CAS 1458105-41-3
3-Oxo-N-[2-(trifluoromethyl)phenyl]piperazine-1-carboxamide
CAS 1458105-41-3C12H12F3N3O2