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Murcko scaffold

Ring system with 5 rings and 28 atoms

23 chemicals on CompoundList share this ring system.

Rings: 5
Scaffold atoms: 28
Chemicals: 23
With full pages: 5

Scaffold SMILES

c1ccc(CN2CCN(c3ncnc4scc(-c5ccccc5)c34)CC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold c1ccc(CN2CCN(c3ncnc4scc(-c5ccccc5)c34)CC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

1-Benzyl-4-{6-methyl-5-phenylthieno[2,3-d]pyrimidin-4-yl}piperazine chemical structure, C24H24N4S, CAS 374693-43-3

1-Benzyl-4-{6-methyl-5-phenylthieno[2,3-d]pyrimidin-4-yl}piperazine

CAS 374693-43-3C₂₄H₂₄N₄S

4-(4-Benzylpiperazin-1-yl)-5-(3,4,5-trimethylphenyl)thieno[2,3-d]pyrimidine chemical structure, C26H28N4S, CAS 374693-47-7

4-(4-Benzylpiperazin-1-yl)-5-(3,4,5-trimethylphenyl)thieno[2,3-d]pyrimidine

CAS 374693-47-7C₂₆H₂₈N₄S

4-(4-Benzylpiperazin-1-yl)-5-(p-tolyl)thieno[2,3-d]pyrimidine chemical structure, C24H24N4S, CAS 433693-41-5

4-(4-Benzylpiperazin-1-yl)-5-(p-tolyl)thieno[2,3-d]pyrimidine

CAS 433693-41-5C₂₄H₂₄N₄S

4-(4-Benzylpiperazin-1-yl)-6-methyl-5-(p-tolyl)thieno[2,3-d]pyrimidine chemical structure, C25H26N4S, CAS 670270-94-7

4-(4-Benzylpiperazin-1-yl)-6-methyl-5-(p-tolyl)thieno[2,3-d]pyrimidine

CAS 670270-94-7C₂₅H₂₆N₄S

4-(4-Benzylpiperazin-1-yl)-5-(4-chlorophenyl)-6-methylthieno[2,3-d]pyrimidine chemical structure, C24H23ClN4S, CAS 500112-13-0

4-(4-Benzylpiperazin-1-yl)-5-(4-chlorophenyl)-6-methylthieno[2,3-d]pyrimidine

CAS 500112-13-0C₂₄H₂₃ClN₄S

4-[4-[(4-Fluorophenyl)methyl]piperazin-1-yl]-5-phenylthieno[2,3-d]pyrimidine chemical structure, C23H21FN4S, CAS 433308-54-4

4-[4-[(4-Fluorophenyl)methyl]piperazin-1-yl]-5-phenylthieno[2,3-d]pyrimidine

CAS 433308-54-4C₂₃H₂₁FN₄S

4-[4-(4-Ethoxybenzyl)piperazin-1-yl]-5-phenylthieno[2,3-d]pyrimidine chemical structure, C25H26N4OS, CAS 611197-44-5

4-[4-(4-Ethoxybenzyl)piperazin-1-yl]-5-phenylthieno[2,3-d]pyrimidine

CAS 611197-44-5C₂₅H₂₆N₄OS

4-[4-(3-Fluoro-4-methoxybenzyl)piperazin-1-yl]-5-phenylthieno[2,3-d]pyrimidine chemical structure, C24H23FN4OS, CAS 433313-71-4

4-[4-(3-Fluoro-4-methoxybenzyl)piperazin-1-yl]-5-phenylthieno[2,3-d]pyrimidine

CAS 433313-71-4C₂₄H₂₃FN₄OS

4-(4-(5-Chloro-2-methoxybenzyl)piperazin-1-yl)-5-phenylthieno[2,3-d]pyrimidine chemical structure, C24H23ClN4OS, CAS 433312-91-5

4-(4-(5-Chloro-2-methoxybenzyl)piperazin-1-yl)-5-phenylthieno[2,3-d]pyrimidine

CAS 433312-91-5C₂₄H₂₃ClN₄OS

4-[4-(5-Fluoro-2-methoxybenzyl)piperazin-1-yl]-5-(4-fluorophenyl)thieno[2,3-d]pyrimidine chemical structure, C24H22F2N4OS, CAS 384377-35-9

4-[4-(5-Fluoro-2-methoxybenzyl)piperazin-1-yl]-5-(4-fluorophenyl)thieno[2,3-d]pyrimidine

CAS 384377-35-9C₂₄H₂₂F₂N₄OS

4-[4-(4-Fluorobenzyl)piperazin-1-yl]-5-(4-fluorophenyl)thieno[2,3-d]pyrimidine chemical structure, C23H20F2N4S, CAS 384793-38-8

4-[4-(4-Fluorobenzyl)piperazin-1-yl]-5-(4-fluorophenyl)thieno[2,3-d]pyrimidine

CAS 384793-38-8C₂₃H₂₀F₂N₄S

4-[4-(5-Chloro-2-methoxybenzyl)piperazin-1-yl]-5-(4-fluorophenyl)thieno[2,3-d]pyrimidine chemical structure, C24H22ClFN4OS, CAS 384803-16-1

4-[4-(5-Chloro-2-methoxybenzyl)piperazin-1-yl]-5-(4-fluorophenyl)thieno[2,3-d]pyrimidine

CAS 384803-16-1C₂₄H₂₂ClFN₄OS

5-(4-Chlorophenyl)-4-[4-(4-fluorobenzyl)piperazin-1-yl]thieno[2,3-d]pyrimidine chemical structure, C23H20ClFN4S, CAS 384803-19-4

5-(4-Chlorophenyl)-4-[4-(4-fluorobenzyl)piperazin-1-yl]thieno[2,3-d]pyrimidine

CAS 384803-19-4C₂₃H₂₀ClFN₄S

5-(4-Chlorophenyl)-4-(4-(3-fluoro-4-methoxybenzyl)piperazin-1-yl)thieno[2,3-d]pyrimidine chemical structure, C24H22ClFN4OS, CAS 433703-21-0

5-(4-Chlorophenyl)-4-(4-(3-fluoro-4-methoxybenzyl)piperazin-1-yl)thieno[2,3-d]pyrimidine

CAS 433703-21-0C₂₄H₂₂ClFN₄OS

4-[4-(4-Methoxybenzyl)piperazin-1-yl]-5-phenylthieno[2,3-d]pyrimidine chemical structure, C24H24N4OS, CAS 433255-71-1

4-[4-(4-Methoxybenzyl)piperazin-1-yl]-5-phenylthieno[2,3-d]pyrimidine

CAS 433255-71-1C₂₄H₂₄N₄OS

5-(4-Chlorophenyl)-4-[4-(2,4-dichlorobenzyl)piperazin-1-yl]thieno[2,3-d]pyrimidine chemical structure, C23H19Cl3N4S, CAS 488827-25-4

5-(4-Chlorophenyl)-4-[4-(2,4-dichlorobenzyl)piperazin-1-yl]thieno[2,3-d]pyrimidine

CAS 488827-25-4C₂₃H₁₉Cl₃N₄S

4-(4-(5-Chloro-2-methoxybenzyl)piperazin-1-yl)-5-(4-chlorophenyl)thieno[2,3-d]pyrimidine chemical structure, C24H22Cl2N4OS, CAS 385389-11-7

4-(4-(5-Chloro-2-methoxybenzyl)piperazin-1-yl)-5-(4-chlorophenyl)thieno[2,3-d]pyrimidine

CAS 385389-11-7C₂₄H₂₂Cl₂N₄OS

4-[4-(2,4-Dichlorobenzyl)piperazin-1-yl]-5-phenylthieno[2,3-d]pyrimidine chemical structure, C23H20Cl2N4S, CAS 433246-46-9

4-[4-(2,4-Dichlorobenzyl)piperazin-1-yl]-5-phenylthieno[2,3-d]pyrimidine

CAS 433246-46-9C₂₃H₂₀Cl₂N₄S

4-[4-(2,4-Dichlorobenzyl)-1-piperazinyl]-5-(4-fluorophenyl)thieno[2,3-d]pyrimidine chemical structure, C23H19Cl2FN4S, CAS 385417-03-8

4-[4-(2,4-Dichlorobenzyl)-1-piperazinyl]-5-(4-fluorophenyl)thieno[2,3-d]pyrimidine

CAS 385417-03-8C₂₃H₁₉Cl₂FN₄S

4-(4-(3,4-Dichlorobenzyl)piperazin-1-yl)-5-phenylthieno[2,3-d]pyrimidine chemical structure, C23H20Cl2N4S, CAS 433313-38-3

4-(4-(3,4-Dichlorobenzyl)piperazin-1-yl)-5-phenylthieno[2,3-d]pyrimidine

CAS 433313-38-3C₂₃H₂₀Cl₂N₄S

4-(4-(3-Fluoro-4-methoxybenzyl)piperazin-1-yl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidine chemical structure, C24H22F2N4OS, CAS 385392-58-5

4-(4-(3-Fluoro-4-methoxybenzyl)piperazin-1-yl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidine

CAS 385392-58-5C₂₄H₂₂F₂N₄OS

4-(4-Benzylpiperazin-1-yl)-5-(4-fluorophenyl)-6-methylthieno[2,3-d]pyrimidine chemical structure, C24H23FN4S, CAS 496022-81-2

4-(4-Benzylpiperazin-1-yl)-5-(4-fluorophenyl)-6-methylthieno[2,3-d]pyrimidine

CAS 496022-81-2C₂₄H₂₃FN₄S

4-[4-(5-Fluoro-2-methoxybenzyl)piperazin-1-yl]-5-phenylthieno[2,3-d]pyrimidine chemical structure, C24H23FN4OS, CAS 683796-66-9

4-[4-(5-Fluoro-2-methoxybenzyl)piperazin-1-yl]-5-phenylthieno[2,3-d]pyrimidine

CAS 683796-66-9C₂₄H₂₃FN₄OS