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Murcko scaffold

Ring system with 4 rings and 23 atoms

12 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
12
With full pages
1
Scaffold SMILES

c1ccc(N2CCC(NCc3cccc4ccccc34)C2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(N2CCC(NCc3cccc4ccccc34)C2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

N-[2-(Dimethylamino)ethyl]-4-[(3S)-3-[[(1R)-1-(1-naphthalenyl)ethyl]amino]-1-pyrrolidinyl]benzenesulfonamide chemical structure, C26H34N4O2S, CAS 870966-19-1
N-[2-(Dimethylamino)ethyl]-4-[(3S)-3-[[(1R)-1-(1-naphthalenyl)ethyl]amino]-1-pyrrolidinyl]benzenesulfonamide
CAS 870966-19-1C26H34N4O2S
Evocalcet impurity 43 chemical structure, C23H24N2O2, CAS 870859-14-6
Evocalcet impurity 43
CAS 870859-14-6C23H24N2O2
N-[4-[(3S)-3-[[(1R)-1-(1-Naphthalenyl)ethyl]amino]-1-pyrrolidinyl]benzoyl]glycine chemical structure, C25H27N3O3, CAS 870963-69-2
N-[4-[(3S)-3-[[(1R)-1-(1-Naphthalenyl)ethyl]amino]-1-pyrrolidinyl]benzoyl]glycine
CAS 870963-69-2C25H27N3O3
4-[(S)-3-[(R)-1-(Naphthalen-1-yl)ethylamino]pyrrolidin-1-yl]benzoic acid hydrochloride chemical structure, C23H25ClN2O2, CAS 870855-05-3
4-[(S)-3-[(R)-1-(Naphthalen-1-yl)ethylamino]pyrrolidin-1-yl]benzoic acid hydrochloride
CAS 870855-05-3C23H25ClN2O2
4-((3S)-3-(((1R)-1-(1-Naphthalenyl)ethyl)amino)-1-pyrrolidinyl)benzeneacetic acid chemical structure, C24H26N2O2, CAS 870964-67-3
4-((3S)-3-(((1R)-1-(1-Naphthalenyl)ethyl)amino)-1-pyrrolidinyl)benzeneacetic acid
CAS 870964-67-3C24H26N2O2
Ethyl 2-(4-((S)-3-(((R)-1-(naphthalen-1-yl)ethyl)amino)pyrrolidin-1-yl)phenyl)acetate chemical structure, C26H30N2O2, CAS 1666124-30-6
Ethyl 2-(4-((S)-3-(((R)-1-(naphthalen-1-yl)ethyl)amino)pyrrolidin-1-yl)phenyl)acetate
CAS 1666124-30-6C26H30N2O2
2-(4-((S)-3-(((R)-1-(Naphthalen-1-yl)ethyl)amino)pyrrolidin-1-yl)phenyl)acetamide chemical structure, C24H27N3O, CAS 2851537-35-2
2-(4-((S)-3-(((R)-1-(Naphthalen-1-yl)ethyl)amino)pyrrolidin-1-yl)phenyl)acetamide
CAS 2851537-35-2C24H27N3O
Evocalcet Impurity 4 HCl chemical structure, C26H31ClN2O2, CAS 1666124-29-3
Evocalcet Impurity 4 HCl
CAS 1666124-29-3C26H31ClN2O2
2-[3-[(3S)-3-[[(1R)-1-Naphthalen-1-ylethyl]amino]pyrrolidin-1-yl]phenyl]acetic acid chemical structure, C24H26N2O2, CAS 870964-68-4
2-[3-[(3S)-3-[[(1R)-1-Naphthalen-1-ylethyl]amino]pyrrolidin-1-yl]phenyl]acetic acid
CAS 870964-68-4C24H26N2O2
Evocalcet impurity 4 chemical structure, C24H26N2O2, CAS 870964-69-5
Evocalcet impurity 4
CAS 870964-69-5C24H26N2O2
Methyl 2-(4-((S)-3-(((R)-1-(naphthalen-1-yl)ethyl)amino)pyrrolidin-1-yl)phenyl)acetate chemical structure, C25H28N2O2, CAS 2982821-45-2
Methyl 2-(4-((S)-3-(((R)-1-(naphthalen-1-yl)ethyl)amino)pyrrolidin-1-yl)phenyl)acetate
CAS 2982821-45-2C25H28N2O2
Evocalcet impurity 52 chemical structure, C26H31ClN2O2
Evocalcet impurity 52
C26H31ClN2O2