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Murcko scaffold

Ring system with 4 rings and 30 atoms

11 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
30
Chemicals
11
With full pages
2
Scaffold SMILES

O=C(CSc1cn(CCNC(=O)c2ccccc2)c2ccccc12)Nc1nncs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1cn(CCNC(=O)c2ccccc2)c2ccccc12)Nc1nncs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 11 of 11 chemicals

N-[2-[3-[2-[(5-Ethylsulfanyl-1,3,4-thiadiazol-2-yl)amino]-2-oxoethyl]sulfanylindol-1-yl]ethyl]-2-methylbenzamide chemical structure, C24H25N5O2S3, CAS 532970-41-5
N-[2-[3-[2-[(5-Ethylsulfanyl-1,3,4-thiadiazol-2-yl)amino]-2-oxoethyl]sulfanylindol-1-yl]ethyl]-2-methylbenzamide
CAS 532970-41-5C24H25N5O2S3
2-Methyl-N-(2-(3-((2-((5-methyl-1,3,4-thiadiazol-2-yl)amino)-2-oxoethyl)thio)-1H-indol-1-yl)ethyl)benzamide chemical structure, C23H23N5O2S2, CAS 532970-42-6
2-Methyl-N-(2-(3-((2-((5-methyl-1,3,4-thiadiazol-2-yl)amino)-2-oxoethyl)thio)-1H-indol-1-yl)ethyl)benzamide
CAS 532970-42-6C23H23N5O2S2
N-[2-[3-[2-[(5-Methyl-1,3,4-thiadiazol-2-yl)amino]-2-oxoethyl]sulfanylindol-1-yl]ethyl]benzamide chemical structure, C22H21N5O2S2, CAS 532969-86-1
N-[2-[3-[2-[(5-Methyl-1,3,4-thiadiazol-2-yl)amino]-2-oxoethyl]sulfanylindol-1-yl]ethyl]benzamide
CAS 532969-86-1C22H21N5O2S2
2,4-Dichloro-N-(2-(3-((2-((5-methyl-1,3,4-thiadiazol-2-yl)amino)-2-oxoethyl)thio)-1H-indol-1-yl)ethyl)benzamide chemical structure, C22H19Cl2N5O2S2, CAS 532975-63-6
2,4-Dichloro-N-(2-(3-((2-((5-methyl-1,3,4-thiadiazol-2-yl)amino)-2-oxoethyl)thio)-1H-indol-1-yl)ethyl)benzamide
CAS 532975-63-6C22H19Cl2N5O2S2
4-Ethoxy-N-[2-[3-[2-[(5-methyl-1,3,4-thiadiazol-2-yl)amino]-2-oxoethyl]sulfanylindol-1-yl]ethyl]benzamide chemical structure, C24H25N5O3S2, CAS 532976-19-5
4-Ethoxy-N-[2-[3-[2-[(5-methyl-1,3,4-thiadiazol-2-yl)amino]-2-oxoethyl]sulfanylindol-1-yl]ethyl]benzamide
CAS 532976-19-5C24H25N5O3S2
2,4-Dichloro-N-[2-[3-[2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)amino]-2-oxoethyl]sulfanylindol-1-yl]ethyl]benzamide chemical structure, C23H21Cl2N5O2S3, CAS 532975-62-5
2,4-Dichloro-N-[2-[3-[2-[(5-ethylsulfanyl-1,3,4-thiadiazol-2-yl)amino]-2-oxoethyl]sulfanylindol-1-yl]ethyl]benzamide
CAS 532975-62-5C23H21Cl2N5O2S3
N-[2-[3-[2-[(5-Ethylsulfanyl-1,3,4-thiadiazol-2-yl)amino]-2-oxoethyl]sulfanylindol-1-yl]ethyl]benzamide chemical structure, C23H23N5O2S3, CAS 532969-85-0
N-[2-[3-[2-[(5-Ethylsulfanyl-1,3,4-thiadiazol-2-yl)amino]-2-oxoethyl]sulfanylindol-1-yl]ethyl]benzamide
CAS 532969-85-0C23H23N5O2S3
N-(2-(3-((2-((5-(Ethylthio)-1,3,4-thiadiazol-2-yl)amino)-2-oxoethyl)thio)-1H-indol-1-yl)ethyl)-3,5-dimethylbenzamide chemical structure, C25H27N5O2S3, CAS 532974-48-4
N-(2-(3-((2-((5-(Ethylthio)-1,3,4-thiadiazol-2-yl)amino)-2-oxoethyl)thio)-1H-indol-1-yl)ethyl)-3,5-dimethylbenzamide
CAS 532974-48-4C25H27N5O2S3
3,5-Dimethyl-N-(2-(3-((2-((5-methyl-1,3,4-thiadiazol-2-yl)amino)-2-oxoethyl)thio)-1H-indol-1-yl)ethyl)benzamide chemical structure, C24H25N5O2S2, CAS 532974-50-8
3,5-Dimethyl-N-(2-(3-((2-((5-methyl-1,3,4-thiadiazol-2-yl)amino)-2-oxoethyl)thio)-1H-indol-1-yl)ethyl)benzamide
CAS 532974-50-8C24H25N5O2S2
4-Methyl-N-[2-[3-[2-[(5-methyl-1,3,4-thiadiazol-2-yl)amino]-2-oxoethyl]sulfanylindol-1-yl]ethyl]benzamide chemical structure, C23H23N5O2S2, CAS 532971-17-8
4-Methyl-N-[2-[3-[2-[(5-methyl-1,3,4-thiadiazol-2-yl)amino]-2-oxoethyl]sulfanylindol-1-yl]ethyl]benzamide
CAS 532971-17-8C23H23N5O2S2
N-(2-(3-((2-((5-(Ethylthio)-1,3,4-thiadiazol-2-yl)amino)-2-oxoethyl)thio)-1H-indol-1-yl)ethyl)-2-methoxybenzamide chemical structure, C24H25N5O3S3, CAS 443333-01-5
N-(2-(3-((2-((5-(Ethylthio)-1,3,4-thiadiazol-2-yl)amino)-2-oxoethyl)thio)-1H-indol-1-yl)ethyl)-2-methoxybenzamide
CAS 443333-01-5C24H25N5O3S3