Murcko scaffold

Ring system with 5 rings and 24 atoms

32 chemicals on CompoundList share this ring system.

Rings: 5
Scaffold atoms: 24
Chemicals: 32
With full pages: 5

Scaffold SMILES

c1ccc(C2=NN3C(C2)c2ccccc2OC3c2cccs2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold c1ccc(C2=NN3C(C2)c2ccccc2OC3c2cccs2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 32 of 32 chemicals

2-(4-Methoxyphenyl)-5-(2-thienyl)-1,10B-dihydropyrazolo(1,5-C)(1,3)benzoxazine

CAS 303060-84-6C₂₁H₁₈N₂O₂S

4(9-CL-5-(2-Thienyl)1,10B-dihydropyrazolo(1,5-C)(1,3)benzoxazin-2-yl)PH ME ether

CAS 303061-16-7C₂₁H₁₇ClN₂O₂S

9-Chloro-2-(4-fluorophenyl)-5-thien-2-yl-1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine

CAS 491615-79-3C₂₀H₁₄ClFN₂OS

7,9-DI-CL-2-(4-Meo-PH)5-(2-thienyl)-1,10B-dihydropyrazolo(1,5-C)(1,3)benzoxazine

CAS 303059-70-3C₂₁H₁₆Cl₂N₂O₂S

7,9-Dichloro-2-(4-fluorophenyl)-5-(2-thienyl)-1,10B-dihydropyrazolo(1,5-C)(1,3)benzoxazine

CAS 477333-63-4C₂₀H₁₃Cl₂FN₂OS

4(9-BR-5-(2-Thienyl)1,10B-dihydropyrazolo(1,5-C)(1,3)benzoxazin-2-yl)PH ME ether

CAS 303061-13-4C₂₁H₁₇BrN₂O₂S

$4-(4-Bromophenyl)-7-(thiophen-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(13),4,9,11-tetraene chemical structure, C20H15BrN2OS, CAS 868155-20-8$

4-(4-Bromophenyl)-7-(thiophen-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(13),4,9,11-tetraene

CAS 868155-20-8C₂₀H₁₅BrN₂OS

$10-Methoxy-4-phenyl-7-(thiophen-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraene chemical structure, C21H18N2O2S, CAS 897759-37-4$

10-Methoxy-4-phenyl-7-(thiophen-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraene

CAS 897759-37-4C₂₁H₁₈N₂O₂S

$7-(3-Methylthiophen-2-yl)-4-phenyl-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraene chemical structure, C21H18N2OS, CAS 899973-18-3$

7-(3-Methylthiophen-2-yl)-4-phenyl-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraene

CAS 899973-18-3C₂₁H₁₈N₂OS

$4-(4-Methoxyphenyl)-7-(3-methylthiophen-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraene chemical structure, C22H20N2O2S, CAS 899728-68-8$

4-(4-Methoxyphenyl)-7-(3-methylthiophen-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraene

CAS 899728-68-8C₂₂H₂₀N₂O₂S

3-(5-(Thiophen-2-yl)-5,10b-dihydro-1H-benzo[e]pyrazolo[1,5-c][1,3]oxazin-2-yl)phenol

CAS 899729-02-3C₂₀H₁₆N₂O₂S

3-(9-Chloro-5-(thiophen-2-yl)-5,10b-dihydro-1H-benzo[e]pyrazolo[1,5-c][1,3]oxazin-2-yl)phenol

CAS 941941-95-3C₂₀H₁₅ClN₂O₂S

$10-Ethoxy-4-(4-methoxyphenyl)-7-(thiophen-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraene chemical structure, C23H22N2O3S, CAS 899746-48-6$

10-Ethoxy-4-(4-methoxyphenyl)-7-(thiophen-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraene

CAS 899746-48-6C₂₃H₂₂N₂O₃S

$4-(4-Ethoxyphenyl)-10-methoxy-7-(thiophen-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraene chemical structure, C23H22N2O3S, CAS 899746-54-4$

4-(4-Ethoxyphenyl)-10-methoxy-7-(thiophen-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraene

CAS 899746-54-4C₂₃H₂₂N₂O₃S

$3-[10-Methoxy-7-(thiophen-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraen-4-yl]phenol chemical structure, C21H18N2O3S, CAS 941941-99-7$

3-[10-Methoxy-7-(thiophen-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraen-4-yl]phenol

CAS 941941-99-7C₂₁H₁₈N₂O₃S

$3-[10-Ethoxy-7-(thiophen-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraen-4-yl]phenol chemical structure, C22H20N2O3S, CAS 900003-83-0$

3-[10-Ethoxy-7-(thiophen-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraen-4-yl]phenol

CAS 900003-83-0C₂₂H₂₀N₂O₃S

$2-[7-(Thiophen-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraen-4-yl]phenol chemical structure, C20H16N2O2S, CAS 896618-79-4$

2-[7-(Thiophen-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraen-4-yl]phenol

CAS 896618-79-4C₂₀H₁₆N₂O₂S

$2-[7-(3-Methylthiophen-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraen-4-yl]phenol chemical structure, C21H18N2O2S, CAS 899984-58-8$

2-[7-(3-Methylthiophen-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraen-4-yl]phenol

CAS 899984-58-8C₂₁H₁₈N₂O₂S

$2-[12-Chloro-7-(thiophen-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraen-4-yl]phenol chemical structure, C20H15ClN2O2S, CAS 896618-92-1$

2-[12-Chloro-7-(thiophen-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraen-4-yl]phenol

CAS 896618-92-1C₂₀H₁₅ClN₂O₂S

$4-Methyl-2-[7-(thiophen-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraen-4-yl]phenol chemical structure, C21H18N2O2S, CAS 896619-31-1$

4-Methyl-2-[7-(thiophen-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraen-4-yl]phenol

CAS 896619-31-1C₂₁H₁₈N₂O₂S

$4-Methyl-2-[7-(3-methylthiophen-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraen-4-yl]phenol chemical structure, C22H20N2O2S, CAS 899973-42-3$

4-Methyl-2-[7-(3-methylthiophen-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraen-4-yl]phenol

CAS 899973-42-3C₂₂H₂₀N₂O₂S

$4-Chloro-2-[7-(thiophen-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraen-4-yl]phenol chemical structure, C20H15ClN2O2S, CAS 896619-06-0$

4-Chloro-2-[7-(thiophen-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraen-4-yl]phenol

CAS 896619-06-0C₂₀H₁₅ClN₂O₂S

$2-[7-(Thiophen-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraen-4-yl]benzene-1,4-diol chemical structure, C20H16N2O3S, CAS 899984-95-3$

2-[7-(Thiophen-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraen-4-yl]benzene-1,4-diol

CAS 899984-95-3C₂₀H₁₆N₂O₃S

$2-Methoxy-4-[7-(thiophen-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraen-4-yl]phenol chemical structure, C21H18N2O3S, CAS 899985-01-4$

2-Methoxy-4-[7-(thiophen-2-yl)-8-oxa-5,6-diazatricyclo[7.4.0.0^{2,6}]trideca-1(9),4,10,12-tetraen-4-yl]phenol

CAS 899985-01-4C₂₁H₁₈N₂O₃S