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Murcko scaffold

Ring system with 3 rings and 22 atoms

16 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 22
Chemicals: 16
With full pages: 8

Scaffold SMILES

O=C(CSc1cccc(-c2cccs2)n1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(CSc1cccc(-c2cccs2)n1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

Methyl 2-[({[3-cyano-6-(2-thienyl)-4-(trifluoromethyl)-2-pyridinyl]sulfanyl}acetyl)amino]benzoate chemical structure, C21H14F3N3O3S2, CAS 665000-15-7

Methyl 2-[({[3-cyano-6-(2-thienyl)-4-(trifluoromethyl)-2-pyridinyl]sulfanyl}acetyl)amino]benzoate

CAS 665000-15-7C₂₁H₁₄F₃N₃O₃S₂

2-((3-Cyano-6-(2-thienyl)-4-(tri-F-ME)-2-pyridinyl)thio)-N-(4-ME-PH)acetamide chemical structure, C20H14F3N3OS2, CAS 332110-37-9

2-((3-Cyano-6-(2-thienyl)-4-(tri-F-ME)-2-pyridinyl)thio)-N-(4-ME-PH)acetamide

CAS 332110-37-9C₂₀H₁₄F₃N₃OS₂

2-((3-Cyano-6-(2-thienyl)-4-(tri-F-ME)-2-pyridinyl)thio)-N-(3-ME-PH)acetamide chemical structure, C20H14F3N3OS2, CAS 332114-11-1

2-((3-Cyano-6-(2-thienyl)-4-(tri-F-ME)-2-pyridinyl)thio)-N-(3-ME-PH)acetamide

CAS 332114-11-1C₂₀H₁₄F₃N₃OS₂

2-((3-Cyano-6-(2-thienyl)-4-(tri-F-ME)-2-pyridinyl)thio)-N-(4-meo-PH)acetamide chemical structure, C20H14F3N3O2S2, CAS 330551-87-6

2-((3-Cyano-6-(2-thienyl)-4-(tri-F-ME)-2-pyridinyl)thio)-N-(4-meo-PH)acetamide

CAS 330551-87-6C₂₀H₁₄F₃N₃O₂S₂

N-(4-CL-PH)-2-((3-Cyano-6-(2-thienyl)-4-(tri-F-ME)-2-pyridinyl)thio)acetamide chemical structure, C19H11ClF3N3OS2, CAS 331466-62-7

N-(4-CL-PH)-2-((3-Cyano-6-(2-thienyl)-4-(tri-F-ME)-2-pyridinyl)thio)acetamide

CAS 331466-62-7C₁₉H₁₁ClF₃N₃OS₂

2-((3-Cyano-6-(2-thienyl)-4-(tri-F-ME)-2-pyridinyl)thio)-N-(2-meo-PH)acetamide chemical structure, C20H14F3N3O2S2, CAS 352329-20-5

2-((3-Cyano-6-(2-thienyl)-4-(tri-F-ME)-2-pyridinyl)thio)-N-(2-meo-PH)acetamide

CAS 352329-20-5C₂₀H₁₄F₃N₃O₂S₂

2-{[3-Cyano-6-(2-thienyl)-4-(trifluoromethyl)-2-pyridinyl]sulfanyl}-N-(4-fluorophenyl)acetamide chemical structure, C19H11F4N3OS2, CAS 309927-03-5

2-{[3-Cyano-6-(2-thienyl)-4-(trifluoromethyl)-2-pyridinyl]sulfanyl}-N-(4-fluorophenyl)acetamide

CAS 309927-03-5C₁₉H₁₁F₄N₃OS₂

2-(3-Cyano-6-thiophen-2-ylpyridin-2-yl)sulfanyl-N-(2,6-difluorophenyl)acetamide chemical structure, C18H11F2N3OS2, CAS 445266-24-0

2-(3-Cyano-6-thiophen-2-ylpyridin-2-yl)sulfanyl-N-(2,6-difluorophenyl)acetamide

CAS 445266-24-0C₁₈H₁₁F₂N₃OS₂

N-(2-Cyanophenyl)-2-((3-cyano-6-(2-thienyl)-4-(trifluoromethyl)-2-pyridinyl)sulfanyl)acetamide chemical structure, C20H11F3N4OS2, CAS 352329-31-8

N-(2-Cyanophenyl)-2-((3-cyano-6-(2-thienyl)-4-(trifluoromethyl)-2-pyridinyl)sulfanyl)acetamide

CAS 352329-31-8C₂₀H₁₁F₃N₄OS₂

2-[3-Cyano-6-thiophen-2-yl-4-(trifluoromethyl)pyridin-2-yl]sulfanyl-N-(4-ethoxyphenyl)acetamide chemical structure, C21H16F3N3O2S2, CAS 617697-41-3

2-[3-Cyano-6-thiophen-2-yl-4-(trifluoromethyl)pyridin-2-yl]sulfanyl-N-(4-ethoxyphenyl)acetamide

CAS 617697-41-3C₂₁H₁₆F₃N₃O₂S₂

2-{[3-Cyano-6-(thiophen-2-yl)-4-(trifluoromethyl)pyridin-2-yl]sulfanyl}-N-(2,6-difluorophenyl)acetamide chemical structure, C19H10F5N3OS2, CAS 496018-65-6

2-{[3-Cyano-6-(thiophen-2-yl)-4-(trifluoromethyl)pyridin-2-yl]sulfanyl}-N-(2,6-difluorophenyl)acetamide

CAS 496018-65-6C₁₉H₁₀F₅N₃OS₂

2-(3-Cyano-6-thiophen-2-ylpyridin-2-yl)sulfanyl-N-(2-iodophenyl)acetamide chemical structure, C18H12IN3OS2, CAS 340813-48-1

2-(3-Cyano-6-thiophen-2-ylpyridin-2-yl)sulfanyl-N-(2-iodophenyl)acetamide

CAS 340813-48-1C₁₈H₁₂IN₃OS₂

2-((3-Cyano-6-(2-thienyl)-4-(tri-F-ME)-2-pyridinyl)thio)-N-(2-F-PH)acetamide chemical structure, C19H11F4N3OS2, CAS 348147-92-2

2-((3-Cyano-6-(2-thienyl)-4-(tri-F-ME)-2-pyridinyl)thio)-N-(2-F-PH)acetamide

CAS 348147-92-2C₁₉H₁₁F₄N₃OS₂

2-[3-Cyano-6-thiophen-2-yl-4-(trifluoromethyl)pyridin-2-yl]sulfanyl-N-[2-(trifluoromethyl)phenyl]acetamide chemical structure, C20H11F6N3OS2, CAS 496787-10-1

2-[3-Cyano-6-thiophen-2-yl-4-(trifluoromethyl)pyridin-2-yl]sulfanyl-N-[2-(trifluoromethyl)phenyl]acetamide

CAS 496787-10-1C₂₀H₁₁F₆N₃OS₂

2-[3-Cyano-6-thiophen-2-yl-4-(trifluoromethyl)pyridin-2-yl]sulfanyl-N-(4-sulfamoylphenyl)acetamide chemical structure, C19H13F3N4O3S3, CAS 337505-17-6

2-[3-Cyano-6-thiophen-2-yl-4-(trifluoromethyl)pyridin-2-yl]sulfanyl-N-(4-sulfamoylphenyl)acetamide

CAS 337505-17-6C₁₉H₁₃F₃N₄O₃S₃

N-(3,5-Bis(trifluoromethyl)phenyl)-2-((3-cyano-6-(2-thienyl)-4-(trifluoromethyl)-2-pyridinyl)sulfanyl)acetamide chemical structure, C21H10F9N3OS2, CAS 330643-81-7

N-(3,5-Bis(trifluoromethyl)phenyl)-2-((3-cyano-6-(2-thienyl)-4-(trifluoromethyl)-2-pyridinyl)sulfanyl)acetamide

CAS 330643-81-7C₂₁H₁₀F₉N₃OS₂