Murcko scaffold
Ring system with 4 rings and 25 atoms
30 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 25
- Chemicals
- 30
- With full pages
- 3
Scaffold SMILES
O=c1c(=Cc2ccccc2)sc2n1C(C=Cc1ccccc1)C=CN=2
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 30 of 30 chemicals
![Ethyl (2Z)-7-methyl-2-[(4-nitrophenyl)methylidene]-3-oxo-5-[(E)-2-phenylethenyl]-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C25H21N3O5S, CAS 5529-12-4](/s/UMMSOLPPKNWVPA-DRXPRRSGSA-N.svg)
Ethyl (2Z)-7-methyl-2-[(4-nitrophenyl)methylidene]-3-oxo-5-[(E)-2-phenylethenyl]-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 5529-12-4C25H21N3O5S
![Methyl (2Z)-7-methyl-2-[(3-nitrophenyl)methylidene]-3-oxo-5-[(E)-2-phenylethenyl]-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C24H19N3O5S, CAS 321976-34-5](/s/KJKJLCKOPZBWRH-IICJTNPGSA-N.svg)
Methyl (2Z)-7-methyl-2-[(3-nitrophenyl)methylidene]-3-oxo-5-[(E)-2-phenylethenyl]-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 321976-34-5C24H19N3O5S
![Ethyl (2Z)-2-[(2-fluorophenyl)methylidene]-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C25H21FN2O3S, CAS 321975-76-2](/s/MIRIQQBJBUKFJZ-TWGYAANKSA-N.svg)
Ethyl (2Z)-2-[(2-fluorophenyl)methylidene]-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 321975-76-2C25H21FN2O3S
![Methyl (8Z)-8-[(2-fluorophenyl)methylidene]-4-methyl-9-oxo-2-[(E)-2-phenylethenyl]-7-thia-1,5-diazabicyclo[4.3.0]nona-3,5-diene-3-carboxylate chemical structure, C24H19FN2O3S, CAS 5564-53-4](/s/ABBHYENHHQTLLR-JBOXLTRLSA-N.svg)
Methyl (8Z)-8-[(2-fluorophenyl)methylidene]-4-methyl-9-oxo-2-[(E)-2-phenylethenyl]-7-thia-1,5-diazabicyclo[4.3.0]nona-3,5-diene-3-carboxylate
CAS 5564-53-4C24H19FN2O3S
![Ethyl (2Z)-2-benzylidene-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C25H22N2O3S, CAS 5567-59-9](/s/BLVSWUWCNBIIJC-VCWRQBOVSA-N.svg)
Ethyl (2Z)-2-benzylidene-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 5567-59-9C25H22N2O3S
![Ethyl 2-(3,4-dichlorobenzylidene)-7-methyl-3-oxo-5-(2-phenylvinyl)-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C25H20Cl2N2O3S, CAS 324071-83-2](/s/YAHJGGKIQDTOON-YVUMUJEDSA-N.svg)
Ethyl 2-(3,4-dichlorobenzylidene)-7-methyl-3-oxo-5-(2-phenylvinyl)-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 324071-83-2C25H20Cl2N2O3S
Ethyl (2E)-2-(2-chloro-6-fluorobenzylidene)-7-methyl-3-oxo-5-((E)-2-phenylethe nyl)-2,3-dihydro-5H-(1,3)thiazolo(3,2-A)pyrimidine-6-carboxylate
CAS 324562-12-1C25H20ClFN2O3S
![(Z)-Methyl 2-(3-bromobenzylidene)-7-methyl-3-oxo-5-((E)-styryl)-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C24H19BrN2O3S, CAS 324566-78-1](/s/POWVNXBPHXMMSH-IICJTNPGSA-N.svg)
(Z)-Methyl 2-(3-bromobenzylidene)-7-methyl-3-oxo-5-((E)-styryl)-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 324566-78-1C24H19BrN2O3S
![Methyl (2Z)-2-(2-chloro-6-fluorobenzylidene)-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C24H18ClFN2O3S, CAS 385420-46-2](/s/BDOMGVCBFWKERG-MUUKASMTSA-N.svg)
Methyl (2Z)-2-(2-chloro-6-fluorobenzylidene)-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 385420-46-2C24H18ClFN2O3S
![Ethyl (2Z)-2-[(2-chlorophenyl)methylidene]-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C25H21ClN2O3S, CAS 321975-75-1](/s/HHUUMOOWEDSZIQ-TWGYAANKSA-N.svg)
Ethyl (2Z)-2-[(2-chlorophenyl)methylidene]-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 321975-75-1C25H21ClN2O3S
![Ethyl (2E)-2-(2,3-dimethoxybenzylidene)-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C27H26N2O5S, CAS 469879-35-4](/s/KANLLFBYASCHRT-SWFHOVNTSA-N.svg)
Ethyl (2E)-2-(2,3-dimethoxybenzylidene)-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 469879-35-4C27H26N2O5S
![(Z)-Ethyl 2-(2,5-dimethoxybenzylidene)-7-methyl-3-oxo-5-((E)-styryl)-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C27H26N2O5S, CAS 537685-43-1](/s/WGEZJFSASYFYPX-KVGZNFPRSA-N.svg)
(Z)-Ethyl 2-(2,5-dimethoxybenzylidene)-7-methyl-3-oxo-5-((E)-styryl)-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 537685-43-1C27H26N2O5S
![Ethyl (2E)-2-(2-methoxybenzylidene)-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C26H24N2O4S, CAS 324543-51-3](/s/WIPLNKIBCNWDQN-SWFHOVNTSA-N.svg)
Ethyl (2E)-2-(2-methoxybenzylidene)-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 324543-51-3C26H24N2O4S
![Ethyl (2E)-2-(2,4-dimethoxybenzylidene)-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-2,3-dihydro-5H-[1,3]thiazolo[3,2-A]pyrimidine-6-carboxylate chemical structure, C27H26N2O5S, CAS 324566-76-9](/s/FQNXUJXMQYVESJ-MXHDTTNDSA-N.svg)
Ethyl (2E)-2-(2,4-dimethoxybenzylidene)-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-2,3-dihydro-5H-[1,3]thiazolo[3,2-A]pyrimidine-6-carboxylate
CAS 324566-76-9C27H26N2O5S
![Ethyl (2Z)-7-methyl-2-[(4-methylphenyl)methylidene]-3-oxo-5-[(E)-2-phenylethenyl]-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C26H24N2O3S, CAS 321976-28-7](/s/CFGHFDUJLFODEN-CWTLDBBMSA-N.svg)
Ethyl (2Z)-7-methyl-2-[(4-methylphenyl)methylidene]-3-oxo-5-[(E)-2-phenylethenyl]-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 321976-28-7C26H24N2O3S
![Ethyl (2Z)-2-[(3,4-dimethoxyphenyl)methylidene]-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C27H26N2O5S, CAS 316361-03-2](/s/DRBHAJZXDXQYFW-KVGZNFPRSA-N.svg)
Ethyl (2Z)-2-[(3,4-dimethoxyphenyl)methylidene]-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 316361-03-2C27H26N2O5S
![Ethyl (2E)-2-[4-(dimethylamino)benzylidene]-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C27H27N3O3S, CAS 313965-75-2](/s/AAXNSNCLZXZSSA-HJGVJQNMSA-N.svg)
Ethyl (2E)-2-[4-(dimethylamino)benzylidene]-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 313965-75-2C27H27N3O3S
![Methyl (2E)-2-(4-methoxybenzylidene)-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C25H22N2O4S, CAS 321976-37-8](/s/UVFIRIWSXWHAAU-KUXVMBIOSA-N.svg)
Methyl (2E)-2-(4-methoxybenzylidene)-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 321976-37-8C25H22N2O4S
![Methyl (2E)-7-methyl-2-(4-methylbenzylidene)-3-oxo-5-[(E)-2-phenylethenyl]-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C25H22N2O3S, CAS 321976-39-0](/s/LCQDLRBIVGVMSK-KMMVFWCYSA-N.svg)
Methyl (2E)-7-methyl-2-(4-methylbenzylidene)-3-oxo-5-[(E)-2-phenylethenyl]-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 321976-39-0C25H22N2O3S
![Methyl (2E)-2-(4-chlorobenzylidene)-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C24H19ClN2O3S, CAS 321976-31-2](/s/XXZUQAHVZWAWDQ-IKVNRTJKSA-N.svg)
Methyl (2E)-2-(4-chlorobenzylidene)-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 321976-31-2C24H19ClN2O3S
![(E)-Ethyl 7-methyl-2-(3-nitrobenzylidene)-3-oxo-5-((E)-styryl)-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C25H21N3O5S, CAS 321975-79-5](/s/VNQDIOAVTDNXCZ-CNTOZLEXSA-N.svg)
(E)-Ethyl 7-methyl-2-(3-nitrobenzylidene)-3-oxo-5-((E)-styryl)-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 321975-79-5C25H21N3O5S
![Ethyl (2E)-2-benzylidene-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C25H22N2O3S, CAS 321975-81-9](/s/BLVSWUWCNBIIJC-OUALVRHLSA-N.svg)
Ethyl (2E)-2-benzylidene-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 321975-81-9C25H22N2O3S
![Methyl (2E)-2-(2,4-dichlorobenzylidene)-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C24H18Cl2N2O3S, CAS 321976-36-7](/s/JUUMWLVNGDSKAG-JOESBUEISA-N.svg)
Methyl (2E)-2-(2,4-dichlorobenzylidene)-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 321976-36-7C24H18Cl2N2O3S
![Ethyl (2E)-2-(4-methoxybenzylidene)-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate chemical structure, C26H24N2O4S, CAS 321976-26-5](/s/WPFLWEYGSMUCRI-CEHHTOFISA-N.svg)
Ethyl (2E)-2-(4-methoxybenzylidene)-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
CAS 321976-26-5C26H24N2O4S
- Ethyl (2E)-2-(4-chlorobenzylidene)-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate313965-74-1C25H21ClN2O3S
- Ethyl (2E)-2-(2,4-dichlorobenzylidene)-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate321975-83-1C25H20Cl2N2O3S
- Ethyl (2E)-2-(3-bromobenzylidene)-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate324543-09-1C25H21BrN2O3S
- Ethyl (2E)-2-[4-(methoxycarbonyl)benzylidene]-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate469879-46-7C27H24N2O5S
- Methyl (2E)-2-(2-chlorobenzylidene)-7-methyl-3-oxo-5-[(E)-2-phenylethenyl]-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate321976-29-8C24H19ClN2O3S
- (Z)-Ethyl 7-methyl-3-oxo-5-((E)-styryl)-2-(3,4,5-trimethoxybenzylidene)-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate537685-33-9C28H28N2O6S