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Murcko scaffold

N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-N-phenyl-4-(pyrrolidin-1-ylsulfonyl)benzamide scaffold

8 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 30
Chemicals: 8
With full pages: 4

Scaffold SMILES

O=C(c1ccc(S(=O)(=O)N2CCCC2)cc1)N(c1ccccc1)C1C=CS(=O)(=O)C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-N-phenyl-4-(pyrrolidin-1-ylsulfonyl)benzamide page

Murcko scaffold O=C(c1ccc(S(=O)(=O)N2CCCC2)cc1)N(c1ccccc1)C1C=CS(=O)(=O)C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 8 of 8 chemicals

N-(4-Chlorophenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-4-(pyrrolidin-1-ylsulfonyl)benzamide chemical structure, C21H21ClN2O5S2, CAS 863007-42-5

N-(4-Chlorophenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-4-(pyrrolidin-1-ylsulfonyl)benzamide

CAS 863007-42-5C₂₁H₂₁ClN₂O₅S₂

N-(3-Chloro-4-methylphenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-4-(pyrrolidin-1-ylsulfonyl)benzamide chemical structure, C22H23ClN2O5S2, CAS 863008-24-6

N-(3-Chloro-4-methylphenyl)-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-4-(pyrrolidin-1-ylsulfonyl)benzamide

CAS 863008-24-6C₂₂H₂₃ClN₂O₅S₂

N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-4-(pyrrolidin-1-ylsulfonyl)-N-(p-tolyl)benzamide chemical structure, C22H24N2O5S2, CAS 863020-67-1

N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-4-(pyrrolidin-1-ylsulfonyl)-N-(p-tolyl)benzamide

CAS 863020-67-1C₂₂H₂₄N₂O₅S₂

N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-N-(4-fluorophenyl)-4-(pyrrolidin-1-ylsulfonyl)benzamide chemical structure, C21H21FN2O5S2, CAS 863022-63-3

N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-N-(4-fluorophenyl)-4-(pyrrolidin-1-ylsulfonyl)benzamide

CAS 863022-63-3C₂₁H₂₁FN₂O₅S₂

N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-N-(4-ethoxyphenyl)-4-(pyrrolidin-1-ylsulfonyl)benzamide chemical structure, C23H26N2O6S2, CAS 863021-05-0

N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-N-(4-ethoxyphenyl)-4-(pyrrolidin-1-ylsulfonyl)benzamide

CAS 863021-05-0C₂₃H₂₆N₂O₆S₂

N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-N-phenyl-4-(pyrrolidin-1-ylsulfonyl)benzamide chemical structure, C21H22N2O5S2, CAS 863021-37-8

N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-N-phenyl-4-(pyrrolidin-1-ylsulfonyl)benzamide

CAS 863021-37-8C₂₁H₂₂N₂O₅S₂

N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-N-(4-methoxyphenyl)-4-(pyrrolidin-1-ylsulfonyl)benzamide chemical structure, C22H24N2O6S2, CAS 863023-09-0

N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-N-(4-methoxyphenyl)-4-(pyrrolidin-1-ylsulfonyl)benzamide

CAS 863023-09-0C₂₂H₂₄N₂O₆S₂

N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-N-(4-isopropylphenyl)-4-(pyrrolidin-1-ylsulfonyl)benzamide chemical structure, C24H28N2O5S2, CAS 863445-24-3

N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-N-(4-isopropylphenyl)-4-(pyrrolidin-1-ylsulfonyl)benzamide

CAS 863445-24-3C₂₄H₂₈N₂O₅S₂