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Murcko scaffold

Ring system with 3 rings and 21 atoms

23 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
23
With full pages
4
Scaffold SMILES

O=C1CC(C(=O)Nc2ccccc2)C2=C(CCCC2=O)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CC(C(=O)Nc2ccccc2)C2=C(CCCC2=O)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

N-(4-Chloro-2,5-dimethoxyphenyl)-7,7-dimethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide chemical structure, C20H23ClN2O5, CAS 774562-61-7
N-(4-Chloro-2,5-dimethoxyphenyl)-7,7-dimethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide
CAS 774562-61-7C20H23ClN2O5
N-(3-Chloro-4-methylphenyl)-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide chemical structure, C17H17ClN2O3, CAS 727391-97-1
N-(3-Chloro-4-methylphenyl)-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide
CAS 727391-97-1C17H17ClN2O3
N-(4-Fluorophenyl)-7,7-dimethyl-2,5-dioxo-3,4,6,8-tetrahydro-1H-quinoline-4-carboxamide chemical structure, C18H19FN2O3, CAS 727392-02-1
N-(4-Fluorophenyl)-7,7-dimethyl-2,5-dioxo-3,4,6,8-tetrahydro-1H-quinoline-4-carboxamide
CAS 727392-02-1C18H19FN2O3
7,7-Dimethyl-N-(4-nitrophenyl)-2,5-dioxo-3,4,6,8-tetrahydro-1H-quinoline-4-carboxamide chemical structure, C18H19N3O5, CAS 727392-09-8
7,7-Dimethyl-N-(4-nitrophenyl)-2,5-dioxo-3,4,6,8-tetrahydro-1H-quinoline-4-carboxamide
CAS 727392-09-8C18H19N3O5
N-(5-Methoxy-2-methylphenyl)-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide chemical structure, C18H20N2O4, CAS 727391-98-2
N-(5-Methoxy-2-methylphenyl)-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide
CAS 727391-98-2C18H20N2O4
N-(2-Fluorophenyl)-7,7-dimethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide chemical structure, C18H19FN2O3, CAS 774562-79-7
N-(2-Fluorophenyl)-7,7-dimethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide
CAS 774562-79-7C18H19FN2O3
N-(4-Chloro-2,5-dimethoxyphenyl)-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide chemical structure, C18H19ClN2O5, CAS 774562-66-2
N-(4-Chloro-2,5-dimethoxyphenyl)-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide
CAS 774562-66-2C18H19ClN2O5
N-(2-Fluorophenyl)-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide chemical structure, C16H15FN2O3, CAS 774562-80-0
N-(2-Fluorophenyl)-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide
CAS 774562-80-0C16H15FN2O3
N-(3-Chloro-2-methylphenyl)-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide chemical structure, C17H17ClN2O3, CAS 774562-64-0
N-(3-Chloro-2-methylphenyl)-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide
CAS 774562-64-0C17H17ClN2O3
N-(3,5-Dichlorophenyl)-2,5-dioxo-1,3,4,6,7,8-hexahydroquinoline-4-carboxamide chemical structure, C16H14Cl2N2O3, CAS 774562-62-8
N-(3,5-Dichlorophenyl)-2,5-dioxo-1,3,4,6,7,8-hexahydroquinoline-4-carboxamide
CAS 774562-62-8C16H14Cl2N2O3
N-(3,4-Dimethylphenyl)-7,7-dimethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide chemical structure, C20H24N2O3, CAS 727391-99-3
N-(3,4-Dimethylphenyl)-7,7-dimethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide
CAS 727391-99-3C20H24N2O3
N-(4-Methoxyphenyl)-7,7-dimethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide chemical structure, C19H22N2O4, CAS 727392-00-9
N-(4-Methoxyphenyl)-7,7-dimethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide
CAS 727392-00-9C19H22N2O4
N-(4-Chlorophenyl)-7,7-dimethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide chemical structure, C18H19ClN2O3, CAS 727392-01-0
N-(4-Chlorophenyl)-7,7-dimethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide
CAS 727392-01-0C18H19ClN2O3
N-(3-Chloro-4-fluorophenyl)-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide chemical structure, C16H14ClFN2O3, CAS 727392-07-6
N-(3-Chloro-4-fluorophenyl)-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide
CAS 727392-07-6C16H14ClFN2O3
N-(3-Chloro-4-fluorophenyl)-7,7-dimethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide chemical structure, C18H18ClFN2O3, CAS 727392-08-7
N-(3-Chloro-4-fluorophenyl)-7,7-dimethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide
CAS 727392-08-7C18H18ClFN2O3
N-(3,5-Dichlorophenyl)-7,7-dimethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide chemical structure, C18H18Cl2N2O3, CAS 774562-58-2
N-(3,5-Dichlorophenyl)-7,7-dimethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide
CAS 774562-58-2C18H18Cl2N2O3
N-[2-Chloro-5-(trifluoromethyl)phenyl]-7,7-dimethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide chemical structure, C19H18ClF3N2O3, CAS 774562-59-3
N-[2-Chloro-5-(trifluoromethyl)phenyl]-7,7-dimethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide
CAS 774562-59-3C19H18ClF3N2O3
Dimethyl 5-{[(7,7-dimethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinolin-4-yl)carbonyl]amino}benzene-1,3-dicarboxylate chemical structure, C22H24N2O7, CAS 774562-72-0
Dimethyl 5-{[(7,7-dimethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinolin-4-yl)carbonyl]amino}benzene-1,3-dicarboxylate
CAS 774562-72-0C22H24N2O7
N-(4-Acetylphenyl)-7,7-dimethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide chemical structure, C20H22N2O4, CAS 774562-77-5
N-(4-Acetylphenyl)-7,7-dimethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide
CAS 774562-77-5C20H22N2O4
Ethyl 4-{[(7,7-dimethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinolin-4-yl)carbonyl]amino}benzoate chemical structure, C21H24N2O5, CAS 775292-56-3
Ethyl 4-{[(7,7-dimethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinolin-4-yl)carbonyl]amino}benzoate
CAS 775292-56-3C21H24N2O5
N-(4-Methoxyphenyl)-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide chemical structure, C17H18N2O4, CAS 727392-05-4
N-(4-Methoxyphenyl)-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide
CAS 727392-05-4C17H18N2O4
Ethyl 4-{[(2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinolin-4-yl)carbonyl]amino}benzoate chemical structure, C19H20N2O5, CAS 775292-57-4
Ethyl 4-{[(2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinolin-4-yl)carbonyl]amino}benzoate
CAS 775292-57-4C19H20N2O5
N-(3-Chloro-2-methylphenyl)-7,7-dimethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide chemical structure, C19H21ClN2O3, CAS 774562-60-6
N-(3-Chloro-2-methylphenyl)-7,7-dimethyl-2,5-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-4-carboxamide
CAS 774562-60-6C19H21ClN2O3