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Murcko scaffold

Ring system with 4 rings and 20 atoms

18 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 20
Chemicals: 18
With full pages: 9

Scaffold SMILES

c1coc(C2=NNC(c3cnc4ccccc4c3)C2)c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold c1coc(C2=NNC(c3cnc4ccccc4c3)C2)c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

4-(5-(2-Chloro-7-methylquinolin-3-yl)-3-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-oxobutanoic acid chemical structure, C21H18ClN3O4, CAS 511237-80-2

4-(5-(2-Chloro-7-methylquinolin-3-yl)-3-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-oxobutanoic acid

CAS 511237-80-2C₂₁H₁₈ClN₃O₄

4-[5-(2-Chloro-8-methylquinolin-3-yl)-3-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-oxobutanoic acid chemical structure, C21H18ClN3O4, CAS 511237-82-4

4-[5-(2-Chloro-8-methylquinolin-3-yl)-3-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-oxobutanoic acid

CAS 511237-82-4C₂₁H₁₈ClN₃O₄

2-Chloro-3-(3-(furan-2-yl)-1-(methylsulfonyl)-4,5-dihydro-1H-pyrazol-5-yl)-8-methylquinoline chemical structure, C18H16ClN3O3S, CAS 565193-26-2

2-Chloro-3-(3-(furan-2-yl)-1-(methylsulfonyl)-4,5-dihydro-1H-pyrazol-5-yl)-8-methylquinoline

CAS 565193-26-2C₁₈H₁₆ClN₃O₃S

5-(5-(2-Chloro-7-methylquinolin-3-yl)-3-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-5-oxopentanoic acid chemical structure, C22H20ClN3O4, CAS 685135-52-8

5-(5-(2-Chloro-7-methylquinolin-3-yl)-3-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-5-oxopentanoic acid

CAS 685135-52-8C₂₂H₂₀ClN₃O₄

2-Chloro-6-ethoxy-3-(3-(furan-2-yl)-1-(methylsulfonyl)-4,5-dihydro-1H-pyrazol-5-yl)quinoline chemical structure, C19H18ClN3O4S, CAS 796880-97-2

2-Chloro-6-ethoxy-3-(3-(furan-2-yl)-1-(methylsulfonyl)-4,5-dihydro-1H-pyrazol-5-yl)quinoline

CAS 796880-97-2C₁₉H₁₈ClN₃O₄S

2-Chloro-3-(3-(furan-2-yl)-1-(methylsulfonyl)-4,5-dihydro-1H-pyrazol-5-yl)-6-methoxyquinoline chemical structure, C18H16ClN3O4S, CAS 796881-45-3

2-Chloro-3-(3-(furan-2-yl)-1-(methylsulfonyl)-4,5-dihydro-1H-pyrazol-5-yl)-6-methoxyquinoline

CAS 796881-45-3C₁₈H₁₆ClN₃O₄S

1-[3-(2-Chloro-6,7-dimethoxyquinolin-3-yl)-5-(furan-2-yl)-3,4-dihydropyrazol-2-yl]ethanone chemical structure, C20H18ClN3O4, CAS 867135-97-5

1-[3-(2-Chloro-6,7-dimethoxyquinolin-3-yl)-5-(furan-2-yl)-3,4-dihydropyrazol-2-yl]ethanone

CAS 867135-97-5C₂₀H₁₈ClN₃O₄

2-Chloro-3-[3-(2-furyl)-1-(methylsulfonyl)-4,5-dihydro-1H-pyrazol-5-yl]-7-methylquinoline chemical structure, C18H16ClN3O3S, CAS 667898-81-9

2-Chloro-3-[3-(2-furyl)-1-(methylsulfonyl)-4,5-dihydro-1H-pyrazol-5-yl]-7-methylquinoline

CAS 667898-81-9C₁₈H₁₆ClN₃O₃S

2-Chloro-3-(3-(furan-2-yl)-1-(methylsulfonyl)-4,5-dihydro-1H-pyrazol-5-yl)-6-methylquinoline chemical structure, C18H16ClN3O3S, CAS 797799-74-7

2-Chloro-3-(3-(furan-2-yl)-1-(methylsulfonyl)-4,5-dihydro-1H-pyrazol-5-yl)-6-methylquinoline

CAS 797799-74-7C₁₈H₁₆ClN₃O₃S

1-(5-(2-Chloro-8-methylquinolin-3-yl)-3-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone chemical structure, C19H16ClN3O2, CAS 797764-65-9

1-(5-(2-Chloro-8-methylquinolin-3-yl)-3-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone

CAS 797764-65-9C₁₉H₁₆ClN₃O₂

5-[3-(2-Chloro-6-methoxy-3-quinolinyl)-5-(2-furanyl)-3,4-dihydropyrazol-2-yl]-5-oxopentanoic acid chemical structure, C22H20ClN3O5, CAS 710967-65-0

5-[3-(2-Chloro-6-methoxy-3-quinolinyl)-5-(2-furanyl)-3,4-dihydropyrazol-2-yl]-5-oxopentanoic acid

CAS 710967-65-0C₂₂H₂₀ClN₃O₅

1-[3-(2-Chloro-7-methylquinolin-3-yl)-5-(furan-2-yl)-3,4-dihydropyrazol-2-yl]ethanone chemical structure, C19H16ClN3O2, CAS 667898-80-8

1-[3-(2-Chloro-7-methylquinolin-3-yl)-5-(furan-2-yl)-3,4-dihydropyrazol-2-yl]ethanone

CAS 667898-80-8C₁₉H₁₆ClN₃O₂

2-Chloro-3-(3-(furan-2-yl)-1-(methylsulfonyl)-4,5-dihydro-1H-pyrazol-5-yl)-6,7-dimethoxyquinoline chemical structure, C19H18ClN3O5S, CAS 864925-17-7

2-Chloro-3-(3-(furan-2-yl)-1-(methylsulfonyl)-4,5-dihydro-1H-pyrazol-5-yl)-6,7-dimethoxyquinoline

CAS 864925-17-7C₁₉H₁₈ClN₃O₅S

2-Chloro-3-[3-(furan-2-yl)-4,5-dihydro-1H-pyrazol-5-yl]-6,7-dimethoxyquinoline chemical structure, C18H16ClN3O3, CAS 923179-41-3

2-Chloro-3-[3-(furan-2-yl)-4,5-dihydro-1H-pyrazol-5-yl]-6,7-dimethoxyquinoline

CAS 923179-41-3C₁₈H₁₆ClN₃O₃

1-(5-(2-Chloro-7-methylquinolin-3-yl)-3-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-2-methylpropan-1-one chemical structure, C21H20ClN3O2, CAS 923132-10-9

1-(5-(2-Chloro-7-methylquinolin-3-yl)-3-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)-2-methylpropan-1-one

CAS 923132-10-9C₂₁H₂₀ClN₃O₂

1-[5-(2-Chloro-7-ethoxyquinolin-3-yl)-3-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-2-methylpropan-1-one chemical structure, C22H22ClN3O3, CAS 923234-35-9

1-[5-(2-Chloro-7-ethoxyquinolin-3-yl)-3-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-2-methylpropan-1-one

CAS 923234-35-9C₂₂H₂₂ClN₃O₃

1-[5-(2-Chloro-8-methylquinolin-3-yl)-3-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-2-methylpropan-1-one chemical structure, C21H20ClN3O2, CAS 923211-52-3

1-[5-(2-Chloro-8-methylquinolin-3-yl)-3-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-2-methylpropan-1-one

CAS 923211-52-3C₂₁H₂₀ClN₃O₂

1-[5-(2-Chloro-8-methylquinolin-3-yl)-3-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]butan-1-one chemical structure, C21H20ClN3O2, CAS 932138-86-8

1-[5-(2-Chloro-8-methylquinolin-3-yl)-3-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]butan-1-one

CAS 932138-86-8C₂₁H₂₀ClN₃O₂