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Murcko scaffold

Ring system with 4 rings and 22 atoms

26 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
26
With full pages
7
Scaffold SMILES

c1ccc(C2OCC3OC(c4ccccc4)OCC3O2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(C2OCC3OC(c4ccccc4)OCC3O2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 26 of 26 chemicals

(2R)-4-Methyl-2,6-diphenyl-4,4a,8,8a-tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxine chemical structure, C19H20O4
(2R)-4-Methyl-2,6-diphenyl-4,4a,8,8a-tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxine
C19H20O4
RefChem:357149 chemical structure, C19H20O5, CAS 59782-28-4
RefChem:357149
CAS 59782-28-4C19H20O5
1,4-DI-O-Benzylidene-5-deoxy-DL-ribitol chemical structure, C19H20O4, CAS 5348-89-0
1,4-DI-O-Benzylidene-5-deoxy-DL-ribitol
CAS 5348-89-0C19H20O4
2,6-Diphenyl-4,4a,8,8a-tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxine-4-carbaldehyde chemical structure, C19H18O5, CAS 32580-00-0
2,6-Diphenyl-4,4a,8,8a-tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxine-4-carbaldehyde
CAS 32580-00-0C19H18O5
2-[Bis(ethylsulfanyl)methyl]-4,9-diphenyl-3,5,8,10-tetraoxabicyclo[4.4.0]decane chemical structure, C23H28O4S2, CAS 13231-45-3
2-[Bis(ethylsulfanyl)methyl]-4,9-diphenyl-3,5,8,10-tetraoxabicyclo[4.4.0]decane
CAS 13231-45-3C23H28O4S2
(1,3:2,4) Dibenzylidene sorbitol (DBS) chemical structure, C20H22O6, CAS 112923-92-9
(1,3:2,4) Dibenzylidene sorbitol (DBS)
CAS 112923-92-9C20H22O6
4-(Iodomethyl)-8-methyl-2,6-diphenyl-4,4a,8,8a-tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxine chemical structure, C20H21IO4, CAS 7464-35-9
4-(Iodomethyl)-8-methyl-2,6-diphenyl-4,4a,8,8a-tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxine
CAS 7464-35-9C20H21IO4
Benzylidene iditol chemical structure, C20H22O6, CAS 13265-76-4
Benzylidene iditol
CAS 13265-76-4C20H22O6
Di-p-methylbenzylidenesorbitol chemical structure, C22H26O6, CAS 81541-12-0
Di-p-methylbenzylidenesorbitol
CAS 81541-12-0C22H26O6
1,3:2,4-Bis-O-((4-methylphenyl)methylene)hexitol chemical structure, C22H26O6, CAS 93379-37-4
1,3:2,4-Bis-O-((4-methylphenyl)methylene)hexitol
CAS 93379-37-4C22H26O6
2,6-Bis(4-ethylphenyl)perhydro-1,3,5,7-tetraoxanaphth-4-ylethane-1,2-diol chemical structure, C24H30O6, CAS 79072-96-1
2,6-Bis(4-ethylphenyl)perhydro-1,3,5,7-tetraoxanaphth-4-ylethane-1,2-diol
CAS 79072-96-1C24H30O6
Dibenzylidenesorbitol chemical structure, C20H22O6, CAS 32647-67-9
Dibenzylidenesorbitol
CAS 32647-67-9C20H22O6
D-Glucitol, 1,3:2,4-bis-O-((4-ethylphenyl)methylene)- chemical structure, C24H30O6, CAS 80124-42-1
D-Glucitol, 1,3:2,4-bis-O-((4-ethylphenyl)methylene)-
CAS 80124-42-1C24H30O6
Dmdbs chemical structure, C24H30O6, CAS 326821-26-5
Dmdbs
CAS 326821-26-5C24H30O6
1,3:2,4-Bis-O-[(3-methylphenyl)methylene]hexitol chemical structure, C22H26O6, CAS 79072-95-0
1,3:2,4-Bis-O-[(3-methylphenyl)methylene]hexitol
CAS 79072-95-0C22H26O6
Dimethyldibenzylidene sorbitol chemical structure, C24H30O6, CAS 135861-56-2
Dimethyldibenzylidene sorbitol
CAS 135861-56-2C24H30O6
(1R)-1-[(4R,4aR,8aS)-6-(4-Chlorophenyl)-2-(4-methylphenyl)-4,4a,8,8a-tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol chemical structure, C21H23ClO6, CAS 88449-66-5
(1R)-1-[(4R,4aR,8aS)-6-(4-Chlorophenyl)-2-(4-methylphenyl)-4,4a,8,8a-tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol
CAS 88449-66-5C21H23ClO6
2,4:3,5-Di-O-benzylidene-L-idaric Acid chemical structure, C20H18O8, CAS 1219147-84-8
2,4:3,5-Di-O-benzylidene-L-idaric Acid
CAS 1219147-84-8C20H18O8
1,2,3-Trideoxy-4,6:5,7-bis-O-((4-propylphenyl)methylene)-nonitol chemical structure, C29H40O6, CAS 882073-43-0
1,2,3-Trideoxy-4,6:5,7-bis-O-((4-propylphenyl)methylene)-nonitol
CAS 882073-43-0C29H40O6
1,3:2,4-Bis-O-((4-chlorophenyl)methylene)-D-glucitol chemical structure, C21H22Cl2O6, CAS 82203-23-4
1,3:2,4-Bis-O-((4-chlorophenyl)methylene)-D-glucitol
CAS 82203-23-4C21H22Cl2O6
2,6-Diphenyl-4,4a,8,8a-tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxine-4-carbaldehyde, hydrate chemical structure, C19H20O6
2,6-Diphenyl-4,4a,8,8a-tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxine-4-carbaldehyde, hydrate
C19H20O6
D-glycero-L-gulo-Nonitol, 7,8,9-trideoxy-3,5:4,6-bis-O-[(R)-(4-propylphenyl)methylene]- chemical structure, C29H40O6, CAS 1192136-44-9
D-glycero-L-gulo-Nonitol, 7,8,9-trideoxy-3,5:4,6-bis-O-[(R)-(4-propylphenyl)methylene]-
CAS 1192136-44-9C29H40O6
[(4R,4aS,8aS)-2,6-Bis(3,4-dimethylphenyl)-4,4a,8,8a-tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]methanol chemical structure, C23H28O5, CAS 464178-19-6
[(4R,4aS,8aS)-2,6-Bis(3,4-dimethylphenyl)-4,4a,8,8a-tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]methanol
CAS 464178-19-6C23H28O5
[(4R,4aR,8R,8aR)-4-(Hydroxymethyl)-2,6-diphenyl-4,4a,8,8a-tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxin-8-yl]methanol chemical structure, C20H22O6, CAS 19342-60-0
[(4R,4aR,8R,8aR)-4-(Hydroxymethyl)-2,6-diphenyl-4,4a,8,8a-tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxin-8-yl]methanol
CAS 19342-60-0C20H22O6