Murcko scaffold
Ring system with 3 rings and 20 atoms
47 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 20
- Chemicals
- 47
- With full pages
- 4
Scaffold SMILES
O=C(Nc1cc2c(s1)CCCCCC2)c1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 47 of 47 chemicals
![2-[(3-Methylbenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide chemical structure, C19H22N2O2S, CAS 541542-67-0](/s/SHPWLVJLQVJYDE-UHFFFAOYSA-N.svg)
2-[(3-Methylbenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide
CAS 541542-67-0C19H22N2O2S
![N-(3-Cyano-4,5,6,7,8,9-hexahydrocycloocta[b]thiophen-2-yl)-2,6-difluorobenzamide chemical structure, C18H16F2N2OS, CAS 445021-49-8](/s/IYUUEUMPIYKCRK-UHFFFAOYSA-N.svg)
N-(3-Cyano-4,5,6,7,8,9-hexahydrocycloocta[b]thiophen-2-yl)-2,6-difluorobenzamide
CAS 445021-49-8C18H16F2N2OS
![2-[(4-Methylbenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide chemical structure, C19H22N2O2S, CAS 321533-48-6](/s/CAIRXACPGWJBHH-UHFFFAOYSA-N.svg)
2-[(4-Methylbenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide
CAS 321533-48-6C19H22N2O2S
![2-[(2-Fluorobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide chemical structure, C18H19FN2O2S, CAS 352687-59-3](/s/HUWYRDGVVDEJSL-UHFFFAOYSA-N.svg)
2-[(2-Fluorobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide
CAS 352687-59-3C18H19FN2O2S
![2-[(3-Methyl-4-nitrobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide chemical structure, C19H21N3O4S, CAS 438466-59-2](/s/SBHRDOYBGQTBRL-UHFFFAOYSA-N.svg)
2-[(3-Methyl-4-nitrobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide
CAS 438466-59-2C19H21N3O4S
![5-Chloro-N-(3-cyano-4,5,6,7,8,9-hexahydrocycloocta[b]thiophen-2-yl)-2-methoxybenzamide chemical structure, C19H19ClN2O2S, CAS 545342-31-2](/s/DNYGPBQONNLTIK-UHFFFAOYSA-N.svg)
5-Chloro-N-(3-cyano-4,5,6,7,8,9-hexahydrocycloocta[b]thiophen-2-yl)-2-methoxybenzamide
CAS 545342-31-2C19H19ClN2O2S
![Methyl 2-[(3,4-dimethoxybenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate chemical structure, C21H25NO5S, CAS 353767-18-7](/s/WKDHEHHPJDXJFR-UHFFFAOYSA-N.svg)
Methyl 2-[(3,4-dimethoxybenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate
CAS 353767-18-7C21H25NO5S
![Ethyl 2-[(3,5-dimethoxybenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate chemical structure, C22H27NO5S, CAS 353785-24-7](/s/XMOMHONWQIIKAW-UHFFFAOYSA-N.svg)
Ethyl 2-[(3,5-dimethoxybenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate
CAS 353785-24-7C22H27NO5S
![Methyl 2-[(4-acetyloxybenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate chemical structure, C21H23NO5S, CAS 317325-56-7](/s/DEBHXMPHPISGDW-UHFFFAOYSA-N.svg)
Methyl 2-[(4-acetyloxybenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate
CAS 317325-56-7C21H23NO5S
![2-[(3,4,5-Triethoxybenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide chemical structure, C24H32N2O5S, CAS 353770-61-3](/s/KCPKKCJFZOQDBQ-UHFFFAOYSA-N.svg)
2-[(3,4,5-Triethoxybenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide
CAS 353770-61-3C24H32N2O5S
![2-[(2-Iodobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide chemical structure, C18H19IN2O2S, CAS 515123-45-2](/s/OLYROLVSYAVLMG-UHFFFAOYSA-N.svg)
2-[(2-Iodobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide
CAS 515123-45-2C18H19IN2O2S
![2-[(3-Methoxybenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide chemical structure, C19H22N2O3S, CAS 560097-89-4](/s/GPHHSQRGMQSNGH-UHFFFAOYSA-N.svg)
2-[(3-Methoxybenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide
CAS 560097-89-4C19H22N2O3S
![Methyl 2-{[(2-chlorophenyl)carbonyl]amino}-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate chemical structure, C19H20ClNO3S, CAS 312530-13-5](/s/SOWGHSFAGLWMLE-UHFFFAOYSA-N.svg)
Methyl 2-{[(2-chlorophenyl)carbonyl]amino}-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate
CAS 312530-13-5C19H20ClNO3S
![2-[(4-Bromobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide chemical structure, C18H19BrN2O2S, CAS 353784-47-1](/s/DYSVNSFMBZAYMT-UHFFFAOYSA-N.svg)
2-[(4-Bromobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide
CAS 353784-47-1C18H19BrN2O2S
![Methyl 2-[(2,6-dimethoxybenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate chemical structure, C21H25NO5S, CAS 353787-38-9](/s/OIPXATZUKUSGQE-UHFFFAOYSA-N.svg)
Methyl 2-[(2,6-dimethoxybenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate
CAS 353787-38-9C21H25NO5S
![Ethyl 2-[(2-fluorobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate chemical structure, C20H22FNO3S, CAS 420093-34-1](/s/OUATYZQCIFKMJM-UHFFFAOYSA-N.svg)
Ethyl 2-[(2-fluorobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate
CAS 420093-34-1C20H22FNO3S
![2-[(2,4-Dichlorobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide chemical structure, C18H18Cl2N2O2S, CAS 420090-40-0](/s/UZXZETIYOAKMDD-UHFFFAOYSA-N.svg)
2-[(2,4-Dichlorobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide
CAS 420090-40-0C18H18Cl2N2O2S
![2-[(2-Methyl-3-nitrobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide chemical structure, C19H21N3O4S, CAS 352683-03-5](/s/PFJYRWCYBHNTEC-UHFFFAOYSA-N.svg)
2-[(2-Methyl-3-nitrobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide
CAS 352683-03-5C19H21N3O4S
![2-[(5-Chloro-2-methoxybenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide chemical structure, C19H21ClN2O3S, CAS 352684-75-4](/s/QDRRDFIPKWXZPZ-UHFFFAOYSA-N.svg)
2-[(5-Chloro-2-methoxybenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide
CAS 352684-75-4C19H21ClN2O3S
![2-[(4-Chloro-2-nitrobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide chemical structure, C18H18ClN3O4S, CAS 352687-32-2](/s/ZQPJDKSPXZPMMM-UHFFFAOYSA-N.svg)
2-[(4-Chloro-2-nitrobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide
CAS 352687-32-2C18H18ClN3O4S
![Ethyl 2-[(3-fluorobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate chemical structure, C20H22FNO3S, CAS 352694-46-3](/s/HXHNIYWMQMEIRH-UHFFFAOYSA-N.svg)
Ethyl 2-[(3-fluorobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate
CAS 352694-46-3C20H22FNO3S
![2-[(2-Nitrobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide chemical structure, C18H19N3O4S, CAS 419558-97-7](/s/CGGNDUKWQOVKLT-UHFFFAOYSA-N.svg)
2-[(2-Nitrobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide
CAS 419558-97-7C18H19N3O4S
![Ethyl 2-{[(3,4-dimethoxyphenyl)carbonyl]amino}-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate chemical structure, C22H27NO5S, CAS 419559-87-8](/s/QWPNVUHWPJJBTM-UHFFFAOYSA-N.svg)
Ethyl 2-{[(3,4-dimethoxyphenyl)carbonyl]amino}-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate
CAS 419559-87-8C22H27NO5S
![2-[(5-Chloro-2-nitrobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide chemical structure, C18H18ClN3O4S, CAS 420093-38-5](/s/XAPDJTMAFKQQDW-UHFFFAOYSA-N.svg)
2-[(5-Chloro-2-nitrobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide
CAS 420093-38-5C18H18ClN3O4S
- Methyl 2-[(3,4,5-trimethoxybenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate353470-04-9C22H27NO6S
- 2-[(3,5-Dimethoxybenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide353471-03-1C20H24N2O4S
- Methyl 2-[(3-methoxybenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate353474-10-9C20H23NO4S
- Methyl 2-[(5-chloro-2-nitrobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate550353-66-7C19H19ClN2O5S
- Ethyl 2-{[(4-ethoxyphenyl)carbonyl]amino}-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate352687-26-4C22H27NO4S
- Methyl 2-[(3-methyl-4-nitrobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate352687-88-8C20H22N2O5S
- 2-[(3,4-Dimethoxybenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide353473-66-2C20H24N2O4S
- 2-Chloro-N-(3-cyano-4,5,6,7,8,9-hexahydrocycloocta[b]thiophen-2-yl)-4,5-difluorobenzamide352692-90-1C18H15ClF2N2OS
- 2-[(2,4-Dimethoxybenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide352699-98-0C20H24N2O4S
- Methyl 2-[(2-iodobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate514856-94-1C19H20INO3S
- Ethyl 2-[(3,5-dimethylbenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate445016-21-7C22H27NO3S
- Methyl 2-[[3-(trifluoromethyl)benzoyl]amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate330955-74-3C20H20F3NO3S
- Ethyl 2-[(2-chloro-4-nitrobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate362499-81-8C20H21ClN2O5S
- Ethyl 2-[(2,3,4,5,6-pentafluorobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate540790-09-8C20H18F5NO3S
- Methyl 2-[(2,4-dichlorobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate544413-72-1C19H19Cl2NO3S
- 2-[[4-(2-Methylpropoxy)benzoyl]amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxamide350988-67-9C22H28N2O3S
- Methyl 2-[(2-methyl-3-nitrobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate544697-80-5C20H22N2O5S
- Methyl 2-[(2-methoxybenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate354545-16-7C20H23NO4S
- Methyl 2-[(3-fluorobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate353474-03-0C19H20FNO3S
- Methyl 2-[(2-fluorobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate354544-92-6C19H20FNO3S
- Methyl 2-[(3,4-difluorobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate445024-69-1C19H19F2NO3S
- Ethyl 2-[(4-isobutoxybenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate350988-89-5C24H31NO4S
- Ethyl 2-[(4-chlorobenzoyl)amino]-4,5,6,7,8,9-hexahydrocycloocta[b]thiophene-3-carboxylate352702-15-9C20H22ClNO3S
Related scaffolds
Same ring framework with different atoms or bond orders
