Murcko scaffold
Ring system with 5 rings and 25 atoms
34 chemicals on CompoundList share this ring system.
- Rings
- 5
- Scaffold atoms
- 25
- Chemicals
- 34
- With full pages
- 3
Scaffold SMILES
O=c1c2c(ncn1-c1ccccc1)-c1ccccc1CC21CCCC1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 34 of 34 chemicals
![2-[3-(4-Methoxyphenyl)-4-oxospiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-2-yl]sulfanylacetamide chemical structure, C25H25N3O3S, CAS 361179-16-0](/s/OBRPAYRWQCRRAC-UHFFFAOYSA-N.svg)
2-[3-(4-Methoxyphenyl)-4-oxospiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-2-yl]sulfanylacetamide
CAS 361179-16-0C25H25N3O3S
![2-[3-(4-Methylphenyl)-4-oxospiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-2-yl]sulfanylacetamide chemical structure, C25H25N3O2S, CAS 337496-18-1](/s/VDQNFNBQMODDJF-UHFFFAOYSA-N.svg)
2-[3-(4-Methylphenyl)-4-oxospiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-2-yl]sulfanylacetamide
CAS 337496-18-1C25H25N3O2S
![2-Hydrazinyl-3-(4-methylphenyl)-3H-spiro[benzo[h]quinazoline-5,1'-cyclopentan]-4(6H)-one chemical structure, C23H24N4O, CAS 5705-18-0](/s/OEVODFPDVOJUEU-UHFFFAOYSA-N.svg)
2-Hydrazinyl-3-(4-methylphenyl)-3H-spiro[benzo[h]quinazoline-5,1'-cyclopentan]-4(6H)-one
CAS 5705-18-0C23H24N4O
![2-Hydrazinyl-3-(4-methoxyphenyl)spiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one chemical structure, C23H24N4O2, CAS 300392-43-2](/s/RHLCNMLLYHQYTD-UHFFFAOYSA-N.svg)
2-Hydrazinyl-3-(4-methoxyphenyl)spiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one
CAS 300392-43-2C23H24N4O2
![2-Ethylsulfanyl-3-(4-methoxyphenyl)spiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one chemical structure, C25H26N2O2S, CAS 330180-92-2](/s/FDDIQTJFBGCJGF-UHFFFAOYSA-N.svg)
2-Ethylsulfanyl-3-(4-methoxyphenyl)spiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one
CAS 330180-92-2C25H26N2O2S
![3-(2-Methylphenyl)-2-methylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one chemical structure, C24H24N2OS, CAS 381683-40-5](/s/IBHXRMRCYFSUIN-UHFFFAOYSA-N.svg)
3-(2-Methylphenyl)-2-methylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one
CAS 381683-40-5C24H24N2OS
![Ethyl 2-[3-(2-methoxyphenyl)-4-oxospiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-2-yl]sulfanylacetate chemical structure, C27H28N2O4S, CAS 488853-98-1](/s/CZWZLKCHSCFZPN-UHFFFAOYSA-N.svg)
Ethyl 2-[3-(2-methoxyphenyl)-4-oxospiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-2-yl]sulfanylacetate
CAS 488853-98-1C27H28N2O4S
![3-(4-Methylphenyl)-2-prop-2-ynylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one chemical structure, C26H24N2OS, CAS 289711-69-9](/s/IWZWQWTXCHWMLA-UHFFFAOYSA-N.svg)
3-(4-Methylphenyl)-2-prop-2-ynylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one
CAS 289711-69-9C26H24N2OS
![3-(4-Methylphenyl)-2-prop-2-enylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one chemical structure, C26H26N2OS, CAS 289711-67-7](/s/LKDOHAIGCZATGK-UHFFFAOYSA-N.svg)
3-(4-Methylphenyl)-2-prop-2-enylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one
CAS 289711-67-7C26H26N2OS
![Ethyl 2-[3-(2-methylphenyl)-4-oxospiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-2-yl]sulfanylacetate chemical structure, C27H28N2O3S, CAS 383370-52-3](/s/UZZAZZKNIKPSKM-UHFFFAOYSA-N.svg)
Ethyl 2-[3-(2-methylphenyl)-4-oxospiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-2-yl]sulfanylacetate
CAS 383370-52-3C27H28N2O3S
![3-(3-Methoxyphenyl)-2-methylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one chemical structure, C24H24N2O2S, CAS 488086-88-0](/s/IOGYPZVQLUYWEV-UHFFFAOYSA-N.svg)
3-(3-Methoxyphenyl)-2-methylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one
CAS 488086-88-0C24H24N2O2S
![2-[3-(4-Methoxyphenyl)-4-oxospiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-2-yl]sulfanylacetonitrile chemical structure, C25H23N3O2S, CAS 312513-66-9](/s/QHPGLAARGSVSBV-UHFFFAOYSA-N.svg)
2-[3-(4-Methoxyphenyl)-4-oxospiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-2-yl]sulfanylacetonitrile
CAS 312513-66-9C25H23N3O2S
![3-(4-Methoxyphenyl)-2-methylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one chemical structure, C24H24N2O2S, CAS 312585-38-9](/s/IVJIIUXQSADZOI-UHFFFAOYSA-N.svg)
3-(4-Methoxyphenyl)-2-methylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one
CAS 312585-38-9C24H24N2O2S
![2-(Butylsulfanyl)-3-(4-methylphenyl)-5,6-dihydrospiro(benzo[h]quinazoline-5,1'-cyclopentane)-4(3H)-one chemical structure, C27H30N2OS, CAS 289711-64-4](/s/QHAVFGVHTBLXLF-UHFFFAOYSA-N.svg)
2-(Butylsulfanyl)-3-(4-methylphenyl)-5,6-dihydrospiro(benzo[h]quinazoline-5,1'-cyclopentane)-4(3H)-one
CAS 289711-64-4C27H30N2OS
![3-(4-Methylphenyl)-2-methylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one chemical structure, C24H24N2OS, CAS 289711-62-2](/s/APGVYYOYBDQBGC-UHFFFAOYSA-N.svg)
3-(4-Methylphenyl)-2-methylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one
CAS 289711-62-2C24H24N2OS
![Ethyl 2-(4-oxo-3-phenylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-2-yl)sulfanylacetate chemical structure, C26H26N2O3S, CAS 301352-37-4](/s/CBIUWHWQKCFSTP-UHFFFAOYSA-N.svg)
Ethyl 2-(4-oxo-3-phenylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-2-yl)sulfanylacetate
CAS 301352-37-4C26H26N2O3S
![2-(2-Hydroxyethylamino)-3-phenylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one chemical structure, C24H25N3O2, CAS 300591-13-3](/s/YFYLSIWJEUCFCV-UHFFFAOYSA-N.svg)
2-(2-Hydroxyethylamino)-3-phenylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one
CAS 300591-13-3C24H25N3O2
![2-Ethylsulfanyl-3-(4-methylphenyl)spiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one chemical structure, C25H26N2OS, CAS 289711-63-3](/s/DCADAEWUMQBDRW-UHFFFAOYSA-N.svg)
2-Ethylsulfanyl-3-(4-methylphenyl)spiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one
CAS 289711-63-3C25H26N2OS
![3-Phenyl-2-prop-2-enylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one chemical structure, C25H24N2OS, CAS 313519-90-3](/s/WNAWJFJSGSQCOR-UHFFFAOYSA-N.svg)
3-Phenyl-2-prop-2-enylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one
CAS 313519-90-3C25H24N2OS
![2-(Ethylsulfanyl)-4-oxo-3-phenyl-3,4,5,6-tetrahydrobenzo[h]quinazoline-5-spiro-1'-cyclopentane chemical structure, C24H24N2OS, CAS 301352-36-3](/s/OPIQYYPDNVZHQL-UHFFFAOYSA-N.svg)
2-(Ethylsulfanyl)-4-oxo-3-phenyl-3,4,5,6-tetrahydrobenzo[h]quinazoline-5-spiro-1'-cyclopentane
CAS 301352-36-3C24H24N2OS
![2-(Methylsulfanyl)-3-phenyl-5,6-dihydro-4(3H)-oxospiro(benzo[h]quinazoline-5,1'-cyclopentane) chemical structure, C23H22N2OS, CAS 301352-38-5](/s/XPNVOBZNQCYYBK-UHFFFAOYSA-N.svg)
2-(Methylsulfanyl)-3-phenyl-5,6-dihydro-4(3H)-oxospiro(benzo[h]quinazoline-5,1'-cyclopentane)
CAS 301352-38-5C23H22N2OS
![2-Butylsulfanyl-3-(4-methoxyphenyl)spiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one chemical structure, C27H30N2O2S, CAS 330454-28-9](/s/JERKOZZLSQQQJY-UHFFFAOYSA-N.svg)
2-Butylsulfanyl-3-(4-methoxyphenyl)spiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one
CAS 330454-28-9C27H30N2O2S
![Ethyl 2-[3-(4-methylphenyl)-4-oxospiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-2-yl]sulfanylacetate chemical structure, C27H28N2O3S, CAS 289711-66-6](/s/WXZQJVQCCRZEMA-UHFFFAOYSA-N.svg)
Ethyl 2-[3-(4-methylphenyl)-4-oxospiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-2-yl]sulfanylacetate
CAS 289711-66-6C27H28N2O3S
![Ethyl 2-[3-(4-methoxyphenyl)-4-oxospiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-2-yl]sulfanylacetate chemical structure, C27H28N2O4S, CAS 312585-32-3](/s/UQZOPYFFCCSVLI-UHFFFAOYSA-N.svg)
Ethyl 2-[3-(4-methoxyphenyl)-4-oxospiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-2-yl]sulfanylacetate
CAS 312585-32-3C27H28N2O4S
- 3-(4-Methoxyphenyl)-2-prop-2-enylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one312585-33-4C26H26N2O2S
- 3-(4-Methoxyphenyl)-2-prop-2-ynylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one331961-87-6C26H24N2O2S
- 3-(4-Methoxyphenyl)-2-propan-2-ylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one5917-13-5C26H28N2O2S
- 2-[3-(4-Methylphenyl)-4-oxospiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-2-yl]sulfanylacetonitrile289711-68-8C25H23N3OS
- 2-(Butylsulfanyl)-3-phenyl-3H-spiro[benzo[h]quinazoline-5,1'-cyclopentan]-4(6H)-one380666-90-0C26H28N2OS
- 2-Ethylsulfanyl-3-(2-methylphenyl)spiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one380567-34-0C25H26N2OS
- 3-Phenyl-2-(propylsulfanyl)-3H-spiro[benzo[h]quinazoline-5,1'-cyclopentan]-4(6H)-one337488-45-6C25H26N2OS
- 3-(2-Methylphenyl)-2-(2-propyn-1-ylthio)spiro[benzo[h]quinazoline-5(3H),1'-cyclopentan]-4(6H)-one429624-17-9C26H24N2OS
- 3-Phenyl-2-prop-2-ynylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one316357-85-4C25H22N2OS
- 3-(4-Methoxyphenyl)-2-propylsulfanylspiro[6H-benzo[h]quinazoline-5,1'-cyclopentane]-4-one337496-23-8C26H28N2O2S
Related scaffolds
Same ring framework with different atoms or bond orders
