Murcko scaffold
Ring system with 5 rings and 23 atoms
37 chemicals on CompoundList share this ring system.
- Rings
- 5
- Scaffold atoms
- 23
- Chemicals
- 37
- With full pages
- 5
Scaffold SMILES
O=c1c2c3c(sc2n2cnnc2n1-c1ccccc1)CCCC3
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 37 of 37 chemicals
![Methyl [(5-oxo-4-phenyl-4,5,6,7,8,9-hexahydro[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-1-yl)sulfanyl]acetate chemical structure, C20H18N4O3S2, CAS 353762-95-5](/s/ODPNXHLHZFYRGV-UHFFFAOYSA-N.svg)
Methyl [(5-oxo-4-phenyl-4,5,6,7,8,9-hexahydro[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-1-yl)sulfanyl]acetate
CAS 353762-95-5C20H18N4O3S2
![1-(Methylsulfanyl)-4-phenyl-6,7,8,9-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one chemical structure, C18H16N4OS2, CAS 331465-38-4](/s/ATIGPYODLAQSFN-UHFFFAOYSA-N.svg)
1-(Methylsulfanyl)-4-phenyl-6,7,8,9-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one
CAS 331465-38-4C18H16N4OS2
![(11S)-11-Methyl-3-methylsulfanyl-7-phenyl-16-thia-2,4,5,7-tetrazatetracyclo[7.7.0.02,6.010,15]hexadeca-1(9),3,5,10(15)-tetraen-8-one chemical structure, C19H18N4OS2](/s/OKHILFGONHSMKB-NSHDSACASA-N.svg)
(11S)-11-Methyl-3-methylsulfanyl-7-phenyl-16-thia-2,4,5,7-tetrazatetracyclo[7.7.0.02,6.010,15]hexadeca-1(9),3,5,10(15)-tetraen-8-one
C19H18N4OS2
![(R)-6-Methyl-1-(methylthio)-4-phenyl-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one chemical structure, C19H18N4OS2](/s/OKHILFGONHSMKB-LLVKDONJSA-N.svg)
(R)-6-Methyl-1-(methylthio)-4-phenyl-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one
C19H18N4OS2
![Ethyl 2-((4-(4-methoxyphenyl)-5-oxo-4,5,6,7,8,9-hexahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-1-yl)thio)acetate chemical structure, C22H22N4O4S2, CAS 372083-16-4](/s/NCHAAPKTHKMCAI-UHFFFAOYSA-N.svg)
Ethyl 2-((4-(4-methoxyphenyl)-5-oxo-4,5,6,7,8,9-hexahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-1-yl)thio)acetate
CAS 372083-16-4C22H22N4O4S2
![4-(4-Methoxyphenyl)-1-((2-methylallyl)thio)-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one chemical structure, C22H22N4O2S2, CAS 332393-17-6](/s/XRIXTEGVHDGQRR-UHFFFAOYSA-N.svg)
4-(4-Methoxyphenyl)-1-((2-methylallyl)thio)-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one
CAS 332393-17-6C22H22N4O2S2
![1-Methyl-4-(4-methylphenyl)-6,7,8,9-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one chemical structure, C19H18N4OS, CAS 354992-52-2](/s/KIZAFEMXEUGTAC-UHFFFAOYSA-N.svg)
1-Methyl-4-(4-methylphenyl)-6,7,8,9-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one
CAS 354992-52-2C19H18N4OS
![4-(4-Methoxyphenyl)-1-methyl-6,7,8,9-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one chemical structure, C19H18N4O2S, CAS 354992-53-3](/s/NRVGKIXVCJPMEJ-UHFFFAOYSA-N.svg)
4-(4-Methoxyphenyl)-1-methyl-6,7,8,9-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one
CAS 354992-53-3C19H18N4O2S
![2-{[4-(2-Methylphenyl)-5-oxo-4,5,6,7,8,9-hexahydro[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-1-yl]sulfanyl}acetamide chemical structure, C20H19N5O2S2, CAS 380563-62-2](/s/JBQMYJMBBVCVJJ-UHFFFAOYSA-N.svg)
2-{[4-(2-Methylphenyl)-5-oxo-4,5,6,7,8,9-hexahydro[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-1-yl]sulfanyl}acetamide
CAS 380563-62-2C20H19N5O2S2
![1-(Ethylsulfanyl)-4-(4-methoxyphenyl)-6,7,8,9-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one chemical structure, C20H20N4O2S2, CAS 351385-63-2](/s/LVEFICUKESEWSQ-UHFFFAOYSA-N.svg)
1-(Ethylsulfanyl)-4-(4-methoxyphenyl)-6,7,8,9-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one
CAS 351385-63-2C20H20N4O2S2
![1-(Ethylthio)-4-(p-tolyl)-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one chemical structure, C20H20N4OS2, CAS 372081-86-2](/s/QFHSTYZNJGZZFA-UHFFFAOYSA-N.svg)
1-(Ethylthio)-4-(p-tolyl)-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one
CAS 372081-86-2C20H20N4OS2
![4-(4-Methoxyphenyl)-1-(methylthio)-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one chemical structure, C19H18N4O2S2, CAS 332393-01-8](/s/CGVWZYRDODYKCO-UHFFFAOYSA-N.svg)
4-(4-Methoxyphenyl)-1-(methylthio)-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one
CAS 332393-01-8C19H18N4O2S2
![1-(Methylthio)-4-(p-tolyl)-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one chemical structure, C19H18N4OS2, CAS 372173-59-6](/s/NVHZUDWRKRWGFW-UHFFFAOYSA-N.svg)
1-(Methylthio)-4-(p-tolyl)-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one
CAS 372173-59-6C19H18N4OS2
![2-((5-Oxo-4-(p-tolyl)-4,5,6,7,8,9-hexahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-1-yl)thio)acetamide chemical structure, C20H19N5O2S2, CAS 372156-30-4](/s/GMVSJDJERUHVCV-UHFFFAOYSA-N.svg)
2-((5-Oxo-4-(p-tolyl)-4,5,6,7,8,9-hexahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-1-yl)thio)acetamide
CAS 372156-30-4C20H19N5O2S2
![4-(4-Methoxyphenyl)-6,7,8,9-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one chemical structure, C18H16N4O2S, CAS 354992-47-5](/s/VCEWIZUJFMOBEC-UHFFFAOYSA-N.svg)
4-(4-Methoxyphenyl)-6,7,8,9-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one
CAS 354992-47-5C18H16N4O2S
![Methyl 2-((4-(4-methoxyphenyl)-5-oxo-4,5,6,7,8,9-hexahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-1-yl)thio)acetate chemical structure, C21H20N4O4S2, CAS 351385-44-9](/s/RQJKKIDMMXXPNG-UHFFFAOYSA-N.svg)
Methyl 2-((4-(4-methoxyphenyl)-5-oxo-4,5,6,7,8,9-hexahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-1-yl)thio)acetate
CAS 351385-44-9C21H20N4O4S2
![1-Methyl-4-(3-methylphenyl)-6,7,8,9-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one chemical structure, C19H18N4OS, CAS 383902-11-2](/s/OCDHIJYPZXAUBT-UHFFFAOYSA-N.svg)
1-Methyl-4-(3-methylphenyl)-6,7,8,9-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one
CAS 383902-11-2C19H18N4OS
![1-(Allylthio)-4-(o-tolyl)-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one chemical structure, C21H20N4OS2, CAS 380875-52-5](/s/OWLHGSMEYPSYSE-UHFFFAOYSA-N.svg)
1-(Allylthio)-4-(o-tolyl)-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one
CAS 380875-52-5C21H20N4OS2
![1-(Heptylsulfanyl)-4-(4-methoxyphenyl)-6,7,8,9-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one chemical structure, C25H30N4O2S2, CAS 332393-12-1](/s/PWZAHOVWKQWVIJ-UHFFFAOYSA-N.svg)
1-(Heptylsulfanyl)-4-(4-methoxyphenyl)-6,7,8,9-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one
CAS 332393-12-1C25H30N4O2S2
![1-(Isopentylthio)-4-(4-methoxyphenyl)-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one chemical structure, C23H26N4O2S2, CAS 351385-43-8](/s/RZFWGNDFMOOCRI-UHFFFAOYSA-N.svg)
1-(Isopentylthio)-4-(4-methoxyphenyl)-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one
CAS 351385-43-8C23H26N4O2S2
![1-(Allylthio)-4-(4-methoxyphenyl)-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one chemical structure, C21H20N4O2S2, CAS 351385-47-2](/s/YHNBTYJSBUSPSV-UHFFFAOYSA-N.svg)
1-(Allylthio)-4-(4-methoxyphenyl)-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one
CAS 351385-47-2C21H20N4O2S2
![1-(Isopentylthio)-4-phenyl-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one chemical structure, C22H24N4OS2, CAS 371956-75-1](/s/WUHSDIIRBGZXGZ-UHFFFAOYSA-N.svg)
1-(Isopentylthio)-4-phenyl-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one
CAS 371956-75-1C22H24N4OS2
![2-((5-Oxo-4-phenyl-4,5,6,7,8,9-hexahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-1-yl)thio)acetamide chemical structure, C19H17N5O2S2, CAS 372085-13-7](/s/FOIPRJDWWRUUBS-UHFFFAOYSA-N.svg)
2-((5-Oxo-4-phenyl-4,5,6,7,8,9-hexahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-1-yl)thio)acetamide
CAS 372085-13-7C19H17N5O2S2
![4-(4-Methoxyphenyl)-1-(propylthio)-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one chemical structure, C21H22N4O2S2, CAS 332393-13-2](/s/FIKQKUKWXQLWHT-UHFFFAOYSA-N.svg)
4-(4-Methoxyphenyl)-1-(propylthio)-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one
CAS 332393-13-2C21H22N4O2S2
- 2-{[4-(4-Methoxyphenyl)-5-oxo-4,5,6,7,8,9-hexahydro[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-1-yl]sulfanyl}acetamide6000-48-2C20H19N5O3S2
- 1-(Isopentylthio)-4-(o-tolyl)-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one383371-81-1C23H26N4OS2
- 1-(Allylsulfanyl)-4-phenyl-6,7,8,9-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one312626-04-3C20H18N4OS2
- 8-tert-Butyl-1-(methylsulfanyl)-4-phenyl-6,7,8,9-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one372176-26-6C22H24N4OS2
- 1,6-Dimethyl-4-phenyl-6,7,8,9-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one375841-14-8C19H18N4OS
- 8-Methyl-4-phenyl-6,7,8,9-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one375359-77-6C18H16N4OS
- 8-Methyl-4-phenyl-1-(propylthio)-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one376371-37-8C21H22N4OS2
- 1-(Allylsulfanyl)-6-methyl-4-phenyl-6,7,8,9-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one440091-49-6C21H20N4OS2
- 4-(4-Methoxyphenyl)-8-methyl-6,7,8,9-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one375356-43-7C19H18N4O2S
- Ethyl 2-((8-methyl-5-oxo-4-phenyl-4,5,6,7,8,9-hexahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-1-yl)thio)acetate374922-55-1C22H22N4O3S2
- 6-Methyl-1-((2-methylallyl)thio)-4-(p-tolyl)-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one381184-40-3C23H24N4OS2
- 1-(Allylthio)-8-(tert-butyl)-4-phenyl-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one372083-66-4C24H26N4OS2
- 6-Methyl-1-(methylsulfanyl)-4-phenyl-6,7,8,9-tetrahydro[1]benzothieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one1611496-70-8C19H18N4OS2
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=c1c2c3c(sc2n2c(=S)[nH]nc2n1-c1ccccc1)CCCC3](/scaffold/QUTZSNOFEQMSJC-UHFFFAOYSA-N/structure.svg)