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Murcko scaffold

Ring system with 4 rings and 26 atoms

16 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
16
With full pages
4
Scaffold SMILES

O=C(CCc1nnc2[nH]c(=O)c3ccccc3n12)NCc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CCc1nnc2[nH]c(=O)c3ccccc3n12)NCc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

N-[(2-Chlorophenyl)methyl]-3-[4-(2-methylpropyl)-5-oxo-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]propanamide chemical structure, C23H24ClN5O2, CAS 902973-15-3
N-[(2-Chlorophenyl)methyl]-3-[4-(2-methylpropyl)-5-oxo-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]propanamide
CAS 902973-15-3C23H24ClN5O2
N-[(4-Methoxyphenyl)methyl]-3-[4-(2-methylpropyl)-5-oxo-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]propanamide chemical structure, C24H27N5O3, CAS 902928-31-8
N-[(4-Methoxyphenyl)methyl]-3-[4-(2-methylpropyl)-5-oxo-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]propanamide
CAS 902928-31-8C24H27N5O3
N-[(3-Methoxyphenyl)methyl]-3-[4-(2-methylpropyl)-5-oxo-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]propanamide chemical structure, C24H27N5O3, CAS 902929-63-9
N-[(3-Methoxyphenyl)methyl]-3-[4-(2-methylpropyl)-5-oxo-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]propanamide
CAS 902929-63-9C24H27N5O3
3-[4-(2-Methylpropyl)-5-oxo-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]-N-(1-phenylethyl)propanamide chemical structure, C24H27N5O2, CAS 902929-67-3
3-[4-(2-Methylpropyl)-5-oxo-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]-N-(1-phenylethyl)propanamide
CAS 902929-67-3C24H27N5O2
3-(4-(3-Isopropoxypropyl)-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl)-N-(1-phenylethyl)propanamide chemical structure, C26H31N5O3, CAS 895648-26-7
3-(4-(3-Isopropoxypropyl)-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl)-N-(1-phenylethyl)propanamide
CAS 895648-26-7C26H31N5O3
N-[(4-Fluorophenyl)methyl]-3-[4-(2-methylpropyl)-5-oxo-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]propanamide chemical structure, C23H24FN5O2, CAS 902972-66-1
N-[(4-Fluorophenyl)methyl]-3-[4-(2-methylpropyl)-5-oxo-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]propanamide
CAS 902972-66-1C23H24FN5O2
N-Benzyl-3-[4-(2-methylpropyl)-5-oxo-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]propanamide chemical structure, C23H25N5O2, CAS 902972-80-9
N-Benzyl-3-[4-(2-methylpropyl)-5-oxo-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]propanamide
CAS 902972-80-9C23H25N5O2
N-[(2-Methoxyphenyl)methyl]-3-[4-(2-methylpropyl)-5-oxo-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]propanamide chemical structure, C24H27N5O3, CAS 902973-37-9
N-[(2-Methoxyphenyl)methyl]-3-[4-(2-methylpropyl)-5-oxo-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]propanamide
CAS 902973-37-9C24H27N5O3
N-[(4-Methylphenyl)methyl]-3-[4-(2-methylpropyl)-5-oxo-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]propanamide chemical structure, C24H27N5O2, CAS 902928-83-0
N-[(4-Methylphenyl)methyl]-3-[4-(2-methylpropyl)-5-oxo-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]propanamide
CAS 902928-83-0C24H27N5O2
N-[(2-Chlorophenyl)methyl]-3-[4-(3-methylbutyl)-5-oxo-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]propanamide chemical structure, C24H26ClN5O2, CAS 902930-31-8
N-[(2-Chlorophenyl)methyl]-3-[4-(3-methylbutyl)-5-oxo-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]propanamide
CAS 902930-31-8C24H26ClN5O2
N-[(4-Chlorophenyl)methyl]-3-[4-(3-methylbutyl)-5-oxo-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]propanamide chemical structure, C24H26ClN5O2, CAS 902930-61-4
N-[(4-Chlorophenyl)methyl]-3-[4-(3-methylbutyl)-5-oxo-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]propanamide
CAS 902930-61-4C24H26ClN5O2
3-[4-(3-Methylbutyl)-5-oxo-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]-N-(1-phenylethyl)propanamide chemical structure, C25H29N5O2, CAS 902931-89-9
3-[4-(3-Methylbutyl)-5-oxo-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl]-N-(1-phenylethyl)propanamide
CAS 902931-89-9C25H29N5O2
OfChi-h-IN-2 chemical structure, C25H28ClN5O3, CAS 902932-91-6
OfChi-h-IN-2
CAS 902932-91-6C25H28ClN5O3
N-[(4-Methoxyphenyl)methyl]-3-{5-oxo-4-[3-(propan-2-yloxy)propyl]-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl}propanamide chemical structure, C26H31N5O4, CAS 902933-03-3
N-[(4-Methoxyphenyl)methyl]-3-{5-oxo-4-[3-(propan-2-yloxy)propyl]-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl}propanamide
CAS 902933-03-3C26H31N5O4
N-[(4-Methylphenyl)methyl]-3-{5-oxo-4-[3-(propan-2-yloxy)propyl]-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl}propanamide chemical structure, C26H31N5O3, CAS 902933-45-3
N-[(4-Methylphenyl)methyl]-3-{5-oxo-4-[3-(propan-2-yloxy)propyl]-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl}propanamide
CAS 902933-45-3C26H31N5O3
N-[(3-Methoxyphenyl)methyl]-3-{5-oxo-4-[3-(propan-2-yloxy)propyl]-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl}propanamide chemical structure, C26H31N5O4, CAS 902934-09-2
N-[(3-Methoxyphenyl)methyl]-3-{5-oxo-4-[3-(propan-2-yloxy)propyl]-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-1-yl}propanamide
CAS 902934-09-2C26H31N5O4