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Murcko scaffold

Ring system with 3 rings and 16 atoms

26 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
26
With full pages
7
Scaffold SMILES

c1ccc(-c2cnc3ncncc3c2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2cnc3ncncc3c2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 26 of 26 chemicals

N-(2-((4-(Diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido(2,3-d)pyrimidin-7-yl)-N'-(1,1-dimethylethyl)urea chemical structure, C28H41N7O3, CAS 219580-11-7
N-(2-((4-(Diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido(2,3-d)pyrimidin-7-yl)-N'-(1,1-dimethylethyl)urea
CAS 219580-11-7C28H41N7O3
1-(2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-(tert-butyl)urea chemical structure, C18H18Cl2N6O, CAS 179343-17-0
1-(2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-(tert-butyl)urea
CAS 179343-17-0C18H18Cl2N6O
6-(2,6-Dichlorophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine chemical structure, C13H9Cl2N5, CAS 26752-70-5
6-(2,6-Dichlorophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine
CAS 26752-70-5C13H9Cl2N5
6-(2,6-Dimethylphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine chemical structure, C15H15N5, CAS 179343-59-0
6-(2,6-Dimethylphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine
CAS 179343-59-0C15H15N5
1-[2-Amino-6-(2,6-dimethylphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea chemical structure, C20H24N6O, CAS 179343-18-1
1-[2-Amino-6-(2,6-dimethylphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea
CAS 179343-18-1C20H24N6O
6-(2,6-Dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine chemical structure, C13H9Br2N5, CAS 179343-23-8
6-(2,6-Dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine
CAS 179343-23-8C13H9Br2N5
6-(3,5-Dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine chemical structure, C15H15N5O2, CAS 192705-78-5
6-(3,5-Dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine
CAS 192705-78-5C15H15N5O2
PD-166866 chemical structure, C20H24N6O3, CAS 192705-79-6
PD-166866
CAS 192705-79-6C20H24N6O3
PD 161570 chemical structure, C26H35Cl2N7O, CAS 192705-80-9
PD 161570
CAS 192705-80-9C26H35Cl2N7O
6-(2,6-Dichlorophenyl)-2-N-[3-(dimethylamino)propyl]pyrido[2,3-d]pyrimidine-2,7-diamine chemical structure, C18H20Cl2N6, CAS 179343-44-3
6-(2,6-Dichlorophenyl)-2-N-[3-(dimethylamino)propyl]pyrido[2,3-d]pyrimidine-2,7-diamine
CAS 179343-44-3C18H20Cl2N6
1-{2-Amino-6-[3,5-bis(trifluoromethyl)phenyl]pyrido[2,3-d]pyrimidin-7-yl}-3-tert-butylurea chemical structure, C20H18F6N6O, CAS 198623-39-1
1-{2-Amino-6-[3,5-bis(trifluoromethyl)phenyl]pyrido[2,3-d]pyrimidin-7-yl}-3-tert-butylurea
CAS 198623-39-1C20H18F6N6O
6-(3,5-Dimethoxyphenyl)-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7-amine chemical structure, C16H16N4O3S, CAS 862370-78-3
6-(3,5-Dimethoxyphenyl)-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7-amine
CAS 862370-78-3C16H16N4O3S
N2-[4-(Diethylamino)butyl]-6-(3,5-dimethoxyphenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine chemical structure, C23H32N6O2, CAS 862370-79-4
N2-[4-(Diethylamino)butyl]-6-(3,5-dimethoxyphenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine
CAS 862370-79-4C23H32N6O2
6-(2,6-Dichlorophenyl)-2-(methylthio)pyrido[2,3-d]pyrimidin-7-amine chemical structure, C14H10Cl2N4S, CAS 179343-52-3
6-(2,6-Dichlorophenyl)-2-(methylthio)pyrido[2,3-d]pyrimidin-7-amine
CAS 179343-52-3C14H10Cl2N4S
1-(2-Amino-6-(3,5-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-(tert-butyl)urea chemical structure, C18H18Cl2N6O, CAS 1135256-66-4
1-(2-Amino-6-(3,5-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-(tert-butyl)urea
CAS 1135256-66-4C18H18Cl2N6O
7-Chloro-2-(methylsulfanyl)-6-phenylpyrido[2,3-d]pyrimidine chemical structure, C14H10ClN3S, CAS 867353-43-3
7-Chloro-2-(methylsulfanyl)-6-phenylpyrido[2,3-d]pyrimidine
CAS 867353-43-3C14H10ClN3S
7-Chloro-6-phenylpyrido[2,3-d]pyrimidin-4-amine chemical structure, C13H9ClN4, CAS 1238325-33-1
7-Chloro-6-phenylpyrido[2,3-d]pyrimidin-4-amine
CAS 1238325-33-1C13H9ClN4
7-Chloro-4-methoxy-6-phenylpyrido[2,3-d]pyrimidine chemical structure, C14H10ClN3O, CAS 1238325-35-3
7-Chloro-4-methoxy-6-phenylpyrido[2,3-d]pyrimidine
CAS 1238325-35-3C14H10ClN3O
Pyrido[2,3-d]pyrimidin-7-amine,6-(5-amino-2-chlorophenyl)-2-(methylthio)- chemical structure, C14H12ClN5S, CAS 850451-73-9
Pyrido[2,3-d]pyrimidin-7-amine,6-(5-amino-2-chlorophenyl)-2-(methylthio)-
CAS 850451-73-9C14H12ClN5S
Pyrido[2,3-d]pyrimidin-7-amine,6-(3-amino-2,6-dichlorophenyl)-2-(methylthio)- chemical structure, C14H11Cl2N5S, CAS 850451-67-1
Pyrido[2,3-d]pyrimidin-7-amine,6-(3-amino-2,6-dichlorophenyl)-2-(methylthio)-
CAS 850451-67-1C14H11Cl2N5S
Ly-3009120 chemical structure, C23H29FN6O, CAS 1454682-72-4
Ly-3009120
CAS 1454682-72-4C23H29FN6O
1-(5-(2-Amino-7-methylpyrido[2,3-d]pyrimidin-6-yl)-2-fluoro-4-methylphenyl)-3-(3,3-dimethylbutyl)urea chemical structure, C22H27FN6O, CAS 1454690-26-6
1-(5-(2-Amino-7-methylpyrido[2,3-d]pyrimidin-6-yl)-2-fluoro-4-methylphenyl)-3-(3,3-dimethylbutyl)urea
CAS 1454690-26-6C22H27FN6O
7-Chloro-6-phenylpyrido[2,3-d]pyrimidine-2-carbonitrile chemical structure, C14H7ClN4, CAS 867353-47-7
7-Chloro-6-phenylpyrido[2,3-d]pyrimidine-2-carbonitrile
CAS 867353-47-7C14H7ClN4
6-(3,5-Dimethoxyphenyl)pyrido[2,3-d]pyrimidin-2-amine chemical structure, C15H14N4O2, CAS 1538605-11-6
6-(3,5-Dimethoxyphenyl)pyrido[2,3-d]pyrimidin-2-amine
CAS 1538605-11-6C15H14N4O2