CompoundList
Sign in
Murcko scaffold

Ring system with 5 rings and 34 atoms

37 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
34
Chemicals
37
With full pages
35
Scaffold SMILES

O=C(CN1C(=O)C(=C2SC(=S)N(Cc3ccccc3)C2=O)c2ccccc21)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CN1C(=O)C(=C2SC(=S)N(Cc3ccccc3)C2=O)c2ccccc21)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 37 of 37 chemicals

2-[(3Z)-3-(3-Benzyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)-2-oxoindol-1-yl]-N-phenylacetamide chemical structure, C26H19N3O3S2, CAS 380579-13-5
2-[(3Z)-3-(3-Benzyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)-2-oxoindol-1-yl]-N-phenylacetamide
CAS 380579-13-5C26H19N3O3S2
N-(2,6-Dimethylphenyl)-2-{(3Z)-3-[3-(4-fluorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-2-oxo-2,3-dihydro-1H-indol-1-YL}acetamide chemical structure, C28H22FN3O3S2, CAS 618077-18-2
N-(2,6-Dimethylphenyl)-2-{(3Z)-3-[3-(4-fluorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-2-oxo-2,3-dihydro-1H-indol-1-YL}acetamide
CAS 618077-18-2C28H22FN3O3S2
N-(2,4-Dimethylphenyl)-2-{(3Z)-3-[3-(4-fluorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-2-oxo-2,3-dihydro-1H-indol-1-yl}acetamide chemical structure, C28H22FN3O3S2, CAS 865593-06-2
N-(2,4-Dimethylphenyl)-2-{(3Z)-3-[3-(4-fluorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-2-oxo-2,3-dihydro-1H-indol-1-yl}acetamide
CAS 865593-06-2C28H22FN3O3S2
N-(3-Bromophenyl)-2-{(3Z)-3-[3-(4-methylbenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-2-oxo-2,3-dihydro-1H-indol-1-YL}acetamide chemical structure, C27H20BrN3O3S2, CAS 618075-23-3
N-(3-Bromophenyl)-2-{(3Z)-3-[3-(4-methylbenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-2-oxo-2,3-dihydro-1H-indol-1-YL}acetamide
CAS 618075-23-3C27H20BrN3O3S2
N-(2-Chlorophenyl)-2-((3Z)-3-(3-(4-methylbenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)acetamide chemical structure, C27H20ClN3O3S2, CAS 618077-35-3
N-(2-Chlorophenyl)-2-((3Z)-3-(3-(4-methylbenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)acetamide
CAS 618077-35-3C27H20ClN3O3S2
2-((3Z)-3-(3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)-N-(2,6-dimethylphenyl)acetamide chemical structure, C28H23N3O3S2, CAS 618079-58-6
2-((3Z)-3-(3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)-N-(2,6-dimethylphenyl)acetamide
CAS 618079-58-6C28H23N3O3S2
2-{(3Z)-3-[3-(2-Chlorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-2-oxo-2,3-dihydro-1H-indol-1-YL}-N-(4-ethoxyphenyl)acetamide chemical structure, C28H22ClN3O4S2, CAS 617696-48-7
2-{(3Z)-3-[3-(2-Chlorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-2-oxo-2,3-dihydro-1H-indol-1-YL}-N-(4-ethoxyphenyl)acetamide
CAS 617696-48-7C28H22ClN3O4S2
2-((3Z)-3-(3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)-N-(2-chlorophenyl)acetamide chemical structure, C26H18ClN3O3S2, CAS 618077-13-7
2-((3Z)-3-(3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)-N-(2-chlorophenyl)acetamide
CAS 618077-13-7C26H18ClN3O3S2
Ethyl 4-[({(3Z)-3-[3-(2-chlorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-2-oxo-2,3-dihydro-1H-indol-1-YL}acetyl)amino]benzoate chemical structure, C29H22ClN3O5S2, CAS 617696-38-5
Ethyl 4-[({(3Z)-3-[3-(2-chlorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-2-oxo-2,3-dihydro-1H-indol-1-YL}acetyl)amino]benzoate
CAS 617696-38-5C29H22ClN3O5S2
2-{(3Z)-3-[3-(2-Chlorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-2-oxo-2,3-dihydro-1H-indol-1-YL}-N-(2,4-dimethylphenyl)acetamide chemical structure, C28H22ClN3O3S2, CAS 618081-10-0
2-{(3Z)-3-[3-(2-Chlorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-2-oxo-2,3-dihydro-1H-indol-1-YL}-N-(2,4-dimethylphenyl)acetamide
CAS 618081-10-0C28H22ClN3O3S2
N-(3-Chlorophenyl)-2-{(3Z)-3-[3-(4-methylbenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-2-oxo-2,3-dihydro-1H-indol-1-YL}acetamide chemical structure, C27H20ClN3O3S2, CAS 617696-37-4
N-(3-Chlorophenyl)-2-{(3Z)-3-[3-(4-methylbenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-2-oxo-2,3-dihydro-1H-indol-1-YL}acetamide
CAS 617696-37-4C27H20ClN3O3S2
N-(2,4-Dimethylphenyl)-2-((3Z)-3-(3-(4-methoxybenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)acetamide chemical structure, C29H25N3O4S2, CAS 618081-22-4
N-(2,4-Dimethylphenyl)-2-((3Z)-3-(3-(4-methoxybenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)acetamide
CAS 618081-22-4C29H25N3O4S2
2-{(3Z)-3-[3-(4-Fluorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-2-oxo-2,3-dihydro-1H-indol-1-YL}-N-(4-methoxyphenyl)acetamide chemical structure, C27H20FN3O4S2, CAS 617696-39-6
2-{(3Z)-3-[3-(4-Fluorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-2-oxo-2,3-dihydro-1H-indol-1-YL}-N-(4-methoxyphenyl)acetamide
CAS 617696-39-6C27H20FN3O4S2
2-{(3Z)-3-[3-(2-Chlorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-2-oxo-2,3-dihydro-1H-indol-1-YL}-N-(2-chlorophenyl)acetamide chemical structure, C26H17Cl2N3O3S2, CAS 618077-33-1
2-{(3Z)-3-[3-(2-Chlorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-2-oxo-2,3-dihydro-1H-indol-1-YL}-N-(2-chlorophenyl)acetamide
CAS 618077-33-1C26H17Cl2N3O3S2
2-((3Z)-3-(3-(2-Chlorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)-N-(4-methylphenyl)acetamide chemical structure, C27H20ClN3O3S2, CAS 609795-12-2
2-((3Z)-3-(3-(2-Chlorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)-N-(4-methylphenyl)acetamide
CAS 609795-12-2C27H20ClN3O3S2
N-(2-Chlorophenyl)-2-((3Z)-2-oxo-3-(4-oxo-3-(1-phenylethyl)-2-thioxo-1,3-thiazolidin-5-ylidene)-2,3-dihydro-1H-indol-1-yl)acetamide chemical structure, C27H20ClN3O3S2, CAS 618077-27-3
N-(2-Chlorophenyl)-2-((3Z)-2-oxo-3-(4-oxo-3-(1-phenylethyl)-2-thioxo-1,3-thiazolidin-5-ylidene)-2,3-dihydro-1H-indol-1-yl)acetamide
CAS 618077-27-3C27H20ClN3O3S2
2-((3Z)-3-(3-(4-Fluorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)-N-(4-methylphenyl)acetamide chemical structure, C27H20FN3O3S2, CAS 609795-15-5
2-((3Z)-3-(3-(4-Fluorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)-N-(4-methylphenyl)acetamide
CAS 609795-15-5C27H20FN3O3S2
2-[(3Z)-3-(3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl]-N-(3-bromophenyl)acetamide chemical structure, C26H18BrN3O3S2, CAS 618075-31-3
2-[(3Z)-3-(3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl]-N-(3-bromophenyl)acetamide
CAS 618075-31-3C26H18BrN3O3S2
N-(4-Chlorophenyl)-2-((3Z)-3-(3-(4-fluorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)acetamide chemical structure, C26H17ClFN3O3S2, CAS 618075-33-5
N-(4-Chlorophenyl)-2-((3Z)-3-(3-(4-fluorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)acetamide
CAS 618075-33-5C26H17ClFN3O3S2
N-(2,6-Dimethylphenyl)-2-((3Z)-3-(3-(4-methylbenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)acetamide chemical structure, C29H25N3O3S2, CAS 618077-16-0
N-(2,6-Dimethylphenyl)-2-((3Z)-3-(3-(4-methylbenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)acetamide
CAS 618077-16-0C29H25N3O3S2
2-((3Z)-3-(3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)-N-(2-methylphenyl)acetamide chemical structure, C27H21N3O3S2, CAS 618072-79-0
2-((3Z)-3-(3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)-N-(2-methylphenyl)acetamide
CAS 618072-79-0C27H21N3O3S2
N-(3,4-Dimethylphenyl)-2-((3Z)-2-oxo-3-(4-oxo-3-(1-phenylethyl)-2-thioxo-1,3-thiazolidin-5-ylidene)-2,3-dihydro-1H-indol-1-yl)acetamide chemical structure, C29H25N3O3S2, CAS 618076-10-1
N-(3,4-Dimethylphenyl)-2-((3Z)-2-oxo-3-(4-oxo-3-(1-phenylethyl)-2-thioxo-1,3-thiazolidin-5-ylidene)-2,3-dihydro-1H-indol-1-yl)acetamide
CAS 618076-10-1C29H25N3O3S2
2-((3Z)-3-(3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)-N-(2,4-dimethoxyphenyl)acetamide chemical structure, C28H23N3O5S2, CAS 617698-47-2
2-((3Z)-3-(3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)-N-(2,4-dimethoxyphenyl)acetamide
CAS 617698-47-2C28H23N3O5S2
Ethyl 4-((((3Z)-3-(3-(4-fluorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)acetyl)amino)benzoate chemical structure, C29H22FN3O5S2, CAS 617696-58-9
Ethyl 4-((((3Z)-3-(3-(4-fluorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl)acetyl)amino)benzoate
CAS 617696-58-9C29H22FN3O5S2