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Murcko scaffold

Ring system with 3 rings and 23 atoms

12 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
23
Chemicals
12
With full pages
2
Scaffold SMILES

O=C(CSc1nnc(COc2ccccc2)[nH]1)Nc1nccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nnc(COc2ccccc2)[nH]1)Nc1nccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

2-[[4-Methyl-5-[(5-methyl-2-propan-2-ylphenoxy)methyl]-1,2,4-triazol-3-yl]sulfanyl]-N-(5-methyl-1,3-thiazol-2-yl)acetamide chemical structure, C20H25N5O2S2, CAS 665016-35-3
2-[[4-Methyl-5-[(5-methyl-2-propan-2-ylphenoxy)methyl]-1,2,4-triazol-3-yl]sulfanyl]-N-(5-methyl-1,3-thiazol-2-yl)acetamide
CAS 665016-35-3C20H25N5O2S2
2-({5-[(2-Isopropyl-5-methylphenoxy)methyl]-4-methyl-4H-1,2,4-triazol-3-yl}thio)-N-1,3-thiazol-2-ylacetamide chemical structure, C19H23N5O2S2, CAS 692775-03-4
2-({5-[(2-Isopropyl-5-methylphenoxy)methyl]-4-methyl-4H-1,2,4-triazol-3-yl}thio)-N-1,3-thiazol-2-ylacetamide
CAS 692775-03-4C19H23N5O2S2
2-[[4-Ethyl-5-[(4-propan-2-ylphenoxy)methyl]-1,2,4-triazol-3-yl]sulfanyl]-N-(1,3-thiazol-2-yl)acetamide chemical structure, C19H23N5O2S2, CAS 693236-42-9
2-[[4-Ethyl-5-[(4-propan-2-ylphenoxy)methyl]-1,2,4-triazol-3-yl]sulfanyl]-N-(1,3-thiazol-2-yl)acetamide
CAS 693236-42-9C19H23N5O2S2
2-{[4-Amino-5-(phenoxymethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(4-methyl-1,3-thiazol-2-yl)acetamide chemical structure, C15H16N6O2S2, CAS 694506-46-2
2-{[4-Amino-5-(phenoxymethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(4-methyl-1,3-thiazol-2-yl)acetamide
CAS 694506-46-2C15H16N6O2S2
2-[[5-[(2-Ethoxy-4-methylphenoxy)methyl]-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]-N-(1,3-thiazol-2-yl)acetamide chemical structure, C20H23N5O3S2, CAS 708252-80-6
2-[[5-[(2-Ethoxy-4-methylphenoxy)methyl]-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]-N-(1,3-thiazol-2-yl)acetamide
CAS 708252-80-6C20H23N5O3S2
2-[[5-[(2,5-Dimethylphenoxy)methyl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-(1,3-thiazol-2-yl)acetamide chemical structure, C17H19N5O2S2, CAS 767326-55-6
2-[[5-[(2,5-Dimethylphenoxy)methyl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-(1,3-thiazol-2-yl)acetamide
CAS 767326-55-6C17H19N5O2S2
2-[[5-[(2,5-Dimethylphenoxy)methyl]-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)acetamide chemical structure, C20H23N5O2S2, CAS 767326-53-4
2-[[5-[(2,5-Dimethylphenoxy)methyl]-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)acetamide
CAS 767326-53-4C20H23N5O2S2
2-({5-[1-(4-Ethylphenoxy)ethyl]-4-methyl-4H-1,2,4-triazol-3-yl}sulfanyl)-N-(1,3-thiazol-2-yl)acetamide chemical structure, C18H21N5O2S2, CAS 665016-40-0
2-({5-[1-(4-Ethylphenoxy)ethyl]-4-methyl-4H-1,2,4-triazol-3-yl}sulfanyl)-N-(1,3-thiazol-2-yl)acetamide
CAS 665016-40-0C18H21N5O2S2
2-[[4-Ethyl-5-(1-phenoxyethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(1,3-thiazol-2-yl)acetamide chemical structure, C17H19N5O2S2, CAS 694487-42-8
2-[[4-Ethyl-5-(1-phenoxyethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(1,3-thiazol-2-yl)acetamide
CAS 694487-42-8C17H19N5O2S2
2-[[4-Ethyl-5-[1-(4-ethylphenoxy)ethyl]-1,2,4-triazol-3-yl]sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)acetamide chemical structure, C20H25N5O2S2, CAS 709003-79-2
2-[[4-Ethyl-5-[1-(4-ethylphenoxy)ethyl]-1,2,4-triazol-3-yl]sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)acetamide
CAS 709003-79-2C20H25N5O2S2
2-({4-Methyl-5-[(2-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)-N-(1,3-thiazol-2-yl)propanamide chemical structure, C17H19N5O2S2, CAS 839696-40-1
2-({4-Methyl-5-[(2-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)-N-(1,3-thiazol-2-yl)propanamide
CAS 839696-40-1C17H19N5O2S2
2-{[4-Methyl-5-(phenoxymethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(1,3-thiazol-2-yl)propanamide chemical structure, C16H17N5O2S2, CAS 878423-56-4
2-{[4-Methyl-5-(phenoxymethyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(1,3-thiazol-2-yl)propanamide
CAS 878423-56-4C16H17N5O2S2