Murcko scaffold
Ring system with 5 rings and 28 atoms
45 chemicals on CompoundList share this ring system.
- Rings
- 5
- Scaffold atoms
- 28
- Chemicals
- 45
- With full pages
- 9
Scaffold SMILES
O=c1c2ccccc2nc(C=Cc2c[nH]c3ccccc23)n1-c1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
![Murcko scaffold O=c1c2ccccc2nc(C=Cc2c[nH]c3ccccc23)n1-c1ccccc1](/scaffold/NNYKXFFUECTJJD-UHFFFAOYSA-N/structure.svg)
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 45 of 45 chemicals
![2-[(E)-2-(1-Methylindol-3-yl)ethenyl]-3-phenylquinazolin-4-one chemical structure, C25H19N3O, CAS 301353-52-6](/s/QLVMMKVYYHBENK-FOCLMDBBSA-N.svg)
2-[(E)-2-(1-Methylindol-3-yl)ethenyl]-3-phenylquinazolin-4-one
CAS 301353-52-6C25H19N3O
![2-[(E)-2-(1,2-Dimethyl-1H-indol-3-yl)ethenyl]-3-(4-methylphenyl)quinazolin-4(3H)-one chemical structure, C27H23N3O, CAS 351338-18-6](/s/CBUZKAZCNXKPJB-WUKNDPDISA-N.svg)
2-[(E)-2-(1,2-Dimethyl-1H-indol-3-yl)ethenyl]-3-(4-methylphenyl)quinazolin-4(3H)-one
CAS 351338-18-6C27H23N3O
![2-[(E)-2-(5-Methoxy-1,2-dimethylindol-3-yl)ethenyl]-3-(4-methylphenyl)quinazolin-4-one chemical structure, C28H25N3O2, CAS 330833-09-5](/s/FCDBSNBZGUXCOZ-JQIJEIRASA-N.svg)
2-[(E)-2-(5-Methoxy-1,2-dimethylindol-3-yl)ethenyl]-3-(4-methylphenyl)quinazolin-4-one
CAS 330833-09-5C28H25N3O2
![2-[(E)-2-(1-Methylindol-3-yl)ethenyl]-3-(3-methylphenyl)quinazolin-4-one chemical structure, C26H21N3O, CAS 304872-74-0](/s/WQLYOLKIHYIITD-CCEZHUSRSA-N.svg)
2-[(E)-2-(1-Methylindol-3-yl)ethenyl]-3-(3-methylphenyl)quinazolin-4-one
CAS 304872-74-0C26H21N3O
![2-[(E)-2-(1,2-Dimethylindol-3-yl)ethenyl]-3-(3-methylphenyl)quinazolin-4-one chemical structure, C27H23N3O, CAS 304872-97-7](/s/UURYXRKPNCOERR-FOCLMDBBSA-N.svg)
2-[(E)-2-(1,2-Dimethylindol-3-yl)ethenyl]-3-(3-methylphenyl)quinazolin-4-one
CAS 304872-97-7C27H23N3O
![3-(4-Methoxyphenyl)-2-[(E)-2-(1-methylindol-3-yl)ethenyl]quinazolin-4-one chemical structure, C26H21N3O2, CAS 304869-92-9](/s/RQMMATILPASSDV-LFIBNONCSA-N.svg)
3-(4-Methoxyphenyl)-2-[(E)-2-(1-methylindol-3-yl)ethenyl]quinazolin-4-one
CAS 304869-92-9C26H21N3O2
![3-(4-Methoxyphenyl)-2-[(E)-2-(2-methyl-1H-indol-3-yl)ethenyl]quinazolin-4-one chemical structure, C26H21N3O2, CAS 300835-93-2](/s/DRSXHNGWDUPJKH-FOCLMDBBSA-N.svg)
3-(4-Methoxyphenyl)-2-[(E)-2-(2-methyl-1H-indol-3-yl)ethenyl]quinazolin-4-one
CAS 300835-93-2C26H21N3O2
![2-[(E)-2-(1,2-Dimethylindol-3-yl)ethenyl]-3-(4-methoxyphenyl)quinazolin-4-one chemical structure, C27H23N3O2, CAS 300835-81-8](/s/VDDWAAYNJMOWSM-WUKNDPDISA-N.svg)
2-[(E)-2-(1,2-Dimethylindol-3-yl)ethenyl]-3-(4-methoxyphenyl)quinazolin-4-one
CAS 300835-81-8C27H23N3O2
![2-[(E)-2-(5-Methoxy-1,2-dimethylindol-3-yl)ethenyl]-3-(3-methylphenyl)quinazolin-4-one chemical structure, C28H25N3O2, CAS 304869-75-8](/s/MPMQHNNPRFRXFT-FYWRMAATSA-N.svg)
2-[(E)-2-(5-Methoxy-1,2-dimethylindol-3-yl)ethenyl]-3-(3-methylphenyl)quinazolin-4-one
CAS 304869-75-8C28H25N3O2
![2-[(E)-2-(5-Methoxy-1,2-dimethylindol-3-yl)ethenyl]-3-(4-methoxyphenyl)quinazolin-4-one chemical structure, C28H25N3O3, CAS 331831-51-7](/s/JUAVHUITEHMQOE-JQIJEIRASA-N.svg)
2-[(E)-2-(5-Methoxy-1,2-dimethylindol-3-yl)ethenyl]-3-(4-methoxyphenyl)quinazolin-4-one
CAS 331831-51-7C28H25N3O3
RefChem:388715
CAS 5806-79-1C27H23N3O2
![2-[(E)-2-(5-Methoxy-1,2-dimethylindol-3-yl)ethenyl]-3-(2-methoxyphenyl)quinazolin-4-one chemical structure, C28H25N3O3, CAS 387361-50-4](/s/OXNUNWVMCBBDHU-JQIJEIRASA-N.svg)
2-[(E)-2-(5-Methoxy-1,2-dimethylindol-3-yl)ethenyl]-3-(2-methoxyphenyl)quinazolin-4-one
CAS 387361-50-4C28H25N3O3
![2-[(E)-2-(1-Methylindol-3-yl)ethenyl]-3-(4-nitrophenyl)quinazolin-4-one chemical structure, C25H18N4O3, CAS 332391-72-7](/s/IFPUVXZTGVAEIA-XNTDXEJSSA-N.svg)
2-[(E)-2-(1-Methylindol-3-yl)ethenyl]-3-(4-nitrophenyl)quinazolin-4-one
CAS 332391-72-7C25H18N4O3
![2-[(E)-2-(1,2-Dimethylindol-3-yl)ethenyl]-3-(3-methoxyphenyl)quinazolin-4-one chemical structure, C27H23N3O2, CAS 364746-77-0](/s/ATISUSNWHGODDQ-FOCLMDBBSA-N.svg)
2-[(E)-2-(1,2-Dimethylindol-3-yl)ethenyl]-3-(3-methoxyphenyl)quinazolin-4-one
CAS 364746-77-0C27H23N3O2
![2-[(E)-2-(1-Methylindol-3-yl)ethenyl]-3-(3-nitrophenyl)quinazolin-4-one chemical structure, C25H18N4O3, CAS 1164536-14-4](/s/XVKOWMBULMXQTC-BUHFOSPRSA-N.svg)
2-[(E)-2-(1-Methylindol-3-yl)ethenyl]-3-(3-nitrophenyl)quinazolin-4-one
CAS 1164536-14-4C25H18N4O3
![3-(3-Methoxyphenyl)-2-[(E)-2-(2-methyl-1H-indol-3-yl)ethenyl]quinazolin-4-one chemical structure, C26H21N3O2, CAS 371781-99-6](/s/PXQXPSGWEIRZCR-CCEZHUSRSA-N.svg)
3-(3-Methoxyphenyl)-2-[(E)-2-(2-methyl-1H-indol-3-yl)ethenyl]quinazolin-4-one
CAS 371781-99-6C26H21N3O2
![2-[(E)-2-(1-Methyl-1H-indol-3-yl)ethenyl]-3-(2-nitrophenyl)quinazolin-4(3H)-one chemical structure, C25H18N4O3, CAS 6000-22-2](/s/MTWSPFMBSBTZGV-CCEZHUSRSA-N.svg)
2-[(E)-2-(1-Methyl-1H-indol-3-yl)ethenyl]-3-(2-nitrophenyl)quinazolin-4(3H)-one
CAS 6000-22-2C25H18N4O3
![2-[(E)-2-(2-Methyl-1H-indol-3-yl)ethenyl]-3-(4-nitrophenyl)quinazolin-4-one chemical structure, C25H18N4O3, CAS 1164472-70-1](/s/WLYURXRLNCOTBD-CCEZHUSRSA-N.svg)
2-[(E)-2-(2-Methyl-1H-indol-3-yl)ethenyl]-3-(4-nitrophenyl)quinazolin-4-one
CAS 1164472-70-1C25H18N4O3
![2-[(E)-2-(1,2-Dimethylindol-3-yl)ethenyl]-3-(4-nitrophenyl)quinazolin-4-one chemical structure, C26H20N4O3, CAS 361989-96-0](/s/WQOGMDABJWDHIQ-FOCLMDBBSA-N.svg)
2-[(E)-2-(1,2-Dimethylindol-3-yl)ethenyl]-3-(4-nitrophenyl)quinazolin-4-one
CAS 361989-96-0C26H20N4O3
![3-(3-Methoxyphenyl)-2-[(E)-2-(1-methylindol-3-yl)ethenyl]quinazolin-4-one chemical structure, C26H21N3O2, CAS 371925-55-2](/s/IPDFZYZZKKWJCT-CCEZHUSRSA-N.svg)
3-(3-Methoxyphenyl)-2-[(E)-2-(1-methylindol-3-yl)ethenyl]quinazolin-4-one
CAS 371925-55-2C26H21N3O2
![2-[(E)-2-(1,2-Dimethylindol-3-yl)ethenyl]-3-phenylquinazolin-4-one chemical structure, C26H21N3O, CAS 371925-49-4](/s/LNZPGXVNWFWCOA-WUKNDPDISA-N.svg)
2-[(E)-2-(1,2-Dimethylindol-3-yl)ethenyl]-3-phenylquinazolin-4-one
CAS 371925-49-4C26H21N3O
![2-[(E)-2-(5-Methoxy-1,2-dimethylindol-3-yl)ethenyl]-3-phenylquinazolin-4-one chemical structure, C27H23N3O2, CAS 312626-02-1](/s/BMCYTOOKZOPDJQ-JQIJEIRASA-N.svg)
2-[(E)-2-(5-Methoxy-1,2-dimethylindol-3-yl)ethenyl]-3-phenylquinazolin-4-one
CAS 312626-02-1C27H23N3O2
![2-[(E)-2-(2-Methyl-1H-indol-3-yl)ethenyl]-3-(3-methylphenyl)quinazolin-4(3H)-one chemical structure, C26H21N3O, CAS 331831-49-3](/s/UCCRMCQATAYMMI-CCEZHUSRSA-N.svg)
2-[(E)-2-(2-Methyl-1H-indol-3-yl)ethenyl]-3-(3-methylphenyl)quinazolin-4(3H)-one
CAS 331831-49-3C26H21N3O
![2-[(E)-2-(1-Methylindol-3-yl)ethenyl]-3-(4-methylphenyl)quinazolin-4-one chemical structure, C26H21N3O, CAS 368434-25-7](/s/KXSMPIHVARWCOZ-DTQAZKPQSA-N.svg)
2-[(E)-2-(1-Methylindol-3-yl)ethenyl]-3-(4-methylphenyl)quinazolin-4-one
CAS 368434-25-7C26H21N3O
- 2-[(E)-2-(2-Methyl-1H-indol-3-yl)ethenyl]-3-(4-methylphenyl)quinazolin-4-one302785-84-8C26H21N3O
- 2-[(E)-2-(1-Methylindol-3-yl)ethenyl]-3-(2-methylphenyl)quinazolin-4-one330946-46-8C26H21N3O
- 2-[(E)-2-(2-Methyl-1H-indol-3-yl)ethenyl]-3-(2-methylphenyl)quinazolin-4-one334505-46-3C26H21N3O
- 2-[(E)-2-(1,2-Dimethylindol-3-yl)ethenyl]-3-(2-methylphenyl)quinazolin-4-one334505-47-4C27H23N3O
- 2-[(E)-2-(5-Methoxy-1,2-dimethylindol-3-yl)ethenyl]-3-(2-methylphenyl)quinazolin-4-one330946-47-9C28H25N3O2
- 3-(2-Methoxyphenyl)-2-[(E)-2-(1-methyl-1H-indol-3-yl)ethenyl]quinazolin-4(3H)-one312585-81-2C26H21N3O2
- 3-(2-Methoxyphenyl)-2-[(E)-2-(2-methyl-1H-indol-3-yl)ethenyl]quinazolin-4-one312585-82-3C26H21N3O2
- 6-Iodo-2-[(E)-2-(1-methylindol-3-yl)ethenyl]-3-phenylquinazolin-4-one361988-16-1C25H18IN3O
- 6-Iodo-2-[(E)-2-(2-methyl-1H-indol-3-yl)ethenyl]-3-phenylquinazolin-4-one350994-97-7C25H18IN3O
- (E)-2-(2-(5-Methoxy-1H-indol-3-yl)vinyl)-3-phenylquinazolin-4(3H)-one838904-63-5C25H19N3O2
- 2-[(E)-2-(1H-Indol-3-yl)ethenyl]-3-(3-methylphenyl)quinazolin-4(3H)-one300732-75-6C25H19N3O
- (E)-2-(2-(1H-Indol-3-yl)vinyl)-6-iodo-3-(m-tolyl)quinazolin-4(3H)-one375839-98-8C25H18IN3O
- 2-[2-(1H-Indol-3-yl)-vinyl]-3-(4-nitro-phenyl)-3H-quinazolin-4-one332391-71-6C24H16N4O3
- (E)-2-(2-(1H-Indol-3-yl)vinyl)-3-(o-tolyl)quinazolin-4(3H)-one334505-45-2C25H19N3O
- 2-[2-(1H-Indol-3-yl)vinyl]-3-(4-methylphenyl)-4(3H)-quinazolinone304877-70-1C25H19N3O
- (2Z)-2-[(2Z)-2-Indol-3-ylideneethylidene]-3-(4-methoxyphenyl)-1H-quinazolin-4-one331831-50-6C25H19N3O2
- (E)-2-(2-(1H-Indol-3-yl)vinyl)-3-(4-chlorophenyl)-6-iodoquinazolin-4(3H)-one695220-15-6C24H15ClIN3O
- (E)-2-(2-(1H-Indol-3-yl)vinyl)-6-iodo-3-phenylquinazolin-4(3H)-one350994-96-6C24H16IN3O
- (E)-2-(2-(1H-Indol-3-yl)vinyl)-3-(3-methoxyphenyl)quinazolin-4(3H)-one332392-50-4C25H19N3O2
- (E)-2-(2-(1H-Indol-3-yl)vinyl)-6-bromo-3-phenylquinazolin-4(3H)-one700858-20-4C24H16BrN3O
- (E)-2-(2-(1H-Indol-3-yl)vinyl)-3-phenylquinazolin-4(3H)-one420095-18-7C24H17N3O
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=c1c2ccccc2nc(CCc2c[nH]c3ccccc23)n1-c1ccccc1](/scaffold/GLXYQAPWRKPVQF-UHFFFAOYSA-N/structure.svg)