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Murcko scaffold

Ring system with 3 rings and 25 atoms

25 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
25
Chemicals
25
With full pages
4
Scaffold SMILES

O=C(CC1C(=O)NC(=S)N1CCc1ccccc1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CC1C(=O)NC(=S)N1CCc1ccccc1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 25 of 25 chemicals

2-[3-[2-(4-Chlorophenyl)ethyl]-1-ethyl-5-oxo-2-sulfanylideneimidazolidin-4-yl]-N-(4-methoxyphenyl)acetamide chemical structure, C22H24ClN3O3S, CAS 473568-26-2
2-[3-[2-(4-Chlorophenyl)ethyl]-1-ethyl-5-oxo-2-sulfanylideneimidazolidin-4-yl]-N-(4-methoxyphenyl)acetamide
CAS 473568-26-2C22H24ClN3O3S
2-{3-[2-(4-Chlorophenyl)ethyl]-1-ethyl-5-oxo-2-thioxoimidazolidin-4-yl}-N-(4-fluorophenyl)acetamide chemical structure, C21H21ClFN3O2S, CAS 473568-27-3
2-{3-[2-(4-Chlorophenyl)ethyl]-1-ethyl-5-oxo-2-thioxoimidazolidin-4-yl}-N-(4-fluorophenyl)acetamide
CAS 473568-27-3C21H21ClFN3O2S
2-[1-Ethyl-3-[2-(4-methoxyphenyl)ethyl]-5-oxo-2-sulfanylideneimidazolidin-4-yl]-N-phenylacetamide chemical structure, C22H25N3O3S, CAS 473568-29-5
2-[1-Ethyl-3-[2-(4-methoxyphenyl)ethyl]-5-oxo-2-sulfanylideneimidazolidin-4-yl]-N-phenylacetamide
CAS 473568-29-5C22H25N3O3S
Ethyl 4-({[1-methyl-5-oxo-3-(2-phenylethyl)-2-thioxoimidazolidin-4-yl]acetyl}amino)benzoate chemical structure, C23H25N3O4S, CAS 1042697-15-3
Ethyl 4-({[1-methyl-5-oxo-3-(2-phenylethyl)-2-thioxoimidazolidin-4-yl]acetyl}amino)benzoate
CAS 1042697-15-3C23H25N3O4S
Methyl 4-[({3-[2-(3,4-dimethoxyphenyl)ethyl]-1-ethyl-5-oxo-2-thioxoimidazolidin-4-yl}acetyl)amino]benzoate chemical structure, C25H29N3O6S, CAS 473568-73-9
Methyl 4-[({3-[2-(3,4-dimethoxyphenyl)ethyl]-1-ethyl-5-oxo-2-thioxoimidazolidin-4-yl}acetyl)amino]benzoate
CAS 473568-73-9C25H29N3O6S
N-(4-Methoxyphenyl)-2-[3-[2-(4-methoxyphenyl)ethyl]-1-methyl-5-oxo-2-sulfanylideneimidazolidin-4-yl]acetamide chemical structure, C22H25N3O4S, CAS 473568-81-9
N-(4-Methoxyphenyl)-2-[3-[2-(4-methoxyphenyl)ethyl]-1-methyl-5-oxo-2-sulfanylideneimidazolidin-4-yl]acetamide
CAS 473568-81-9C22H25N3O4S
N-(4-Fluorophenyl)-2-[1-methyl-5-oxo-3-(2-phenylethyl)-2-thioxoimidazolidin-4-yl]acetamide chemical structure, C20H20FN3O2S, CAS 1008262-19-8
N-(4-Fluorophenyl)-2-[1-methyl-5-oxo-3-(2-phenylethyl)-2-thioxoimidazolidin-4-yl]acetamide
CAS 1008262-19-8C20H20FN3O2S
2-[3-[2-(3,4-Dimethoxyphenyl)ethyl]-1-methyl-5-oxo-2-sulfanylideneimidazolidin-4-yl]-N-(4-fluorophenyl)acetamide chemical structure, C22H24FN3O4S, CAS 1022919-34-1
2-[3-[2-(3,4-Dimethoxyphenyl)ethyl]-1-methyl-5-oxo-2-sulfanylideneimidazolidin-4-yl]-N-(4-fluorophenyl)acetamide
CAS 1022919-34-1C22H24FN3O4S
Methyl 4-[[2-[3-[2-(3,4-dimethoxyphenyl)ethyl]-1-methyl-5-oxo-2-sulfanylideneimidazolidin-4-yl]acetyl]amino]benzoate chemical structure, C24H27N3O6S, CAS 1033606-23-3
Methyl 4-[[2-[3-[2-(3,4-dimethoxyphenyl)ethyl]-1-methyl-5-oxo-2-sulfanylideneimidazolidin-4-yl]acetyl]amino]benzoate
CAS 1033606-23-3C24H27N3O6S
Methyl 4-({[1-ethyl-5-oxo-3-(2-phenylethyl)-2-thioxoimidazolidin-4-yl]acetyl}amino)benzoate chemical structure, C23H25N3O4S, CAS 473573-89-6
Methyl 4-({[1-ethyl-5-oxo-3-(2-phenylethyl)-2-thioxoimidazolidin-4-yl]acetyl}amino)benzoate
CAS 473573-89-6C23H25N3O4S
2-[3-[2-(4-Chlorophenyl)ethyl]-1-ethyl-5-oxo-2-sulfanylideneimidazolidin-4-yl]-N-phenylacetamide chemical structure, C21H22ClN3O2S, CAS 473573-98-7
2-[3-[2-(4-Chlorophenyl)ethyl]-1-ethyl-5-oxo-2-sulfanylideneimidazolidin-4-yl]-N-phenylacetamide
CAS 473573-98-7C21H22ClN3O2S
2-[1-Ethyl-3-[2-(4-fluorophenyl)ethyl]-5-oxo-2-sulfanylideneimidazolidin-4-yl]-N-(4-methoxyphenyl)acetamide chemical structure, C22H24FN3O3S, CAS 1022923-54-1
2-[1-Ethyl-3-[2-(4-fluorophenyl)ethyl]-5-oxo-2-sulfanylideneimidazolidin-4-yl]-N-(4-methoxyphenyl)acetamide
CAS 1022923-54-1C22H24FN3O3S
N-(4-Ethoxyphenyl)-2-[1-ethyl-3-[2-(2-fluorophenyl)ethyl]-5-oxo-2-sulfanylideneimidazolidin-4-yl]acetamide chemical structure, C23H26FN3O3S, CAS 1022923-69-8
N-(4-Ethoxyphenyl)-2-[1-ethyl-3-[2-(2-fluorophenyl)ethyl]-5-oxo-2-sulfanylideneimidazolidin-4-yl]acetamide
CAS 1022923-69-8C23H26FN3O3S
2-{1-Ethyl-3-[2-(4-fluorophenyl)ethyl]-5-oxo-2-thioxoimidazolidin-4-yl}-N-(4-fluorophenyl)acetamide chemical structure, C21H21F2N3O2S, CAS 1009576-55-9
2-{1-Ethyl-3-[2-(4-fluorophenyl)ethyl]-5-oxo-2-thioxoimidazolidin-4-yl}-N-(4-fluorophenyl)acetamide
CAS 1009576-55-9C21H21F2N3O2S
N-(2-Fluorophenyl)-2-{1-methyl-5-oxo-3-[2-(4-sulfamoylphenyl)ethyl]-2-sulfanylideneimidazolidin-4-YL}acetamide chemical structure, C20H21FN4O4S2, CAS 1008202-41-2
N-(2-Fluorophenyl)-2-{1-methyl-5-oxo-3-[2-(4-sulfamoylphenyl)ethyl]-2-sulfanylideneimidazolidin-4-YL}acetamide
CAS 1008202-41-2C20H21FN4O4S2
N-(4-Methoxyphenyl)-2-[1-methyl-5-oxo-3-[2-(4-sulfamoylphenyl)ethyl]-2-sulfanylideneimidazolidin-4-yl]acetamide chemical structure, C21H24N4O5S2, CAS 1093412-55-5
N-(4-Methoxyphenyl)-2-[1-methyl-5-oxo-3-[2-(4-sulfamoylphenyl)ethyl]-2-sulfanylideneimidazolidin-4-yl]acetamide
CAS 1093412-55-5C21H24N4O5S2
Methyl (3-[2-(4-chlorophenyl)ethyl]-4-{2-[(4-methoxyphenyl)amino]-2-oxoethyl}-5-oxo-2-thioxoimidazolidin-1-yl)acetate chemical structure, C23H24ClN3O5S, CAS 1022923-93-8
Methyl (3-[2-(4-chlorophenyl)ethyl]-4-{2-[(4-methoxyphenyl)amino]-2-oxoethyl}-5-oxo-2-thioxoimidazolidin-1-yl)acetate
CAS 1022923-93-8C23H24ClN3O5S
N-(3-Ethoxyphenyl)-2-[1-ethyl-3-[2-(4-fluorophenyl)ethyl]-5-oxo-2-sulfanylideneimidazolidin-4-yl]acetamide chemical structure, C23H26FN3O3S, CAS 1022918-75-7
N-(3-Ethoxyphenyl)-2-[1-ethyl-3-[2-(4-fluorophenyl)ethyl]-5-oxo-2-sulfanylideneimidazolidin-4-yl]acetamide
CAS 1022918-75-7C23H26FN3O3S
Ethyl 4-[({3-[2-(4-fluorophenyl)ethyl]-1-methyl-5-oxo-2-thioxoimidazolidin-4-yl}acetyl)amino]benzoate chemical structure, C23H24FN3O4S, CAS 1042134-70-2
Ethyl 4-[({3-[2-(4-fluorophenyl)ethyl]-1-methyl-5-oxo-2-thioxoimidazolidin-4-yl}acetyl)amino]benzoate
CAS 1042134-70-2C23H24FN3O4S
2-[3-[2-(2-Fluorophenyl)ethyl]-1-methyl-5-oxo-2-sulfanylideneimidazolidin-4-yl]-N-(4-methoxyphenyl)acetamide chemical structure, C21H22FN3O3S, CAS 1009520-64-2
2-[3-[2-(2-Fluorophenyl)ethyl]-1-methyl-5-oxo-2-sulfanylideneimidazolidin-4-yl]-N-(4-methoxyphenyl)acetamide
CAS 1009520-64-2C21H22FN3O3S
2-[1-Ethyl-3-[2-(2-fluorophenyl)ethyl]-5-oxo-2-sulfanylideneimidazolidin-4-yl]-N-(4-fluorophenyl)acetamide chemical structure, C21H21F2N3O2S, CAS 1008002-91-2
2-[1-Ethyl-3-[2-(2-fluorophenyl)ethyl]-5-oxo-2-sulfanylideneimidazolidin-4-yl]-N-(4-fluorophenyl)acetamide
CAS 1008002-91-2C21H21F2N3O2S
Bas 02280203 chemical structure, C22H24FN3O3S, CAS 4846-62-2
Bas 02280203
CAS 4846-62-2C22H24FN3O3S
N-(4-Chlorophenyl)-2-{3-[2-(4-chlorophenyl)ethyl]-1-methyl-5-oxo-2-thioxoimidazolidin-4-yl}acetamide chemical structure, C20H19Cl2N3O2S, CAS 1037700-77-8
N-(4-Chlorophenyl)-2-{3-[2-(4-chlorophenyl)ethyl]-1-methyl-5-oxo-2-thioxoimidazolidin-4-yl}acetamide
CAS 1037700-77-8C20H19Cl2N3O2S
2-{3-[2-(4-Chlorophenyl)ethyl]-1-ethyl-5-oxo-2-thioxoimidazolidin-4-yl}-N-(4-propoxyphenyl)acetamide chemical structure, C24H28ClN3O3S, CAS 1031207-69-8
2-{3-[2-(4-Chlorophenyl)ethyl]-1-ethyl-5-oxo-2-thioxoimidazolidin-4-yl}-N-(4-propoxyphenyl)acetamide
CAS 1031207-69-8C24H28ClN3O3S