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Murcko scaffold

Ring system with 5 rings and 36 atoms

33 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
36
Chemicals
33
With full pages
6
Scaffold SMILES

O=C1N(Cc2ccccc2)C(Cc2ccccc2)CCC(Cc2ccccc2)N1Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1N(Cc2ccccc2)C(Cc2ccccc2)CCC(Cc2ccccc2)N1Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 33 of 33 chemicals

(4R,5S,6S,7R)-Hexahydro-5,6-dihydroxy-1,3-bis((4-(hydroxymethyl)phenyl)methyl)-4,7-bis(phenylmethyl)-2H-1,3-diazepin-2-one chemical structure, C35H38N2O5, CAS 151867-81-1
(4R,5S,6S,7R)-Hexahydro-5,6-dihydroxy-1,3-bis((4-(hydroxymethyl)phenyl)methyl)-4,7-bis(phenylmethyl)-2H-1,3-diazepin-2-one
CAS 151867-81-1C35H38N2O5
XM 323 chemical structure, C35H38N2O5, CAS 152344-10-0
XM 323
CAS 152344-10-0C35H38N2O5
Mozenavir chemical structure, C33H36N4O3, CAS 174391-92-5
Mozenavir
CAS 174391-92-5C33H36N4O3
2H-1,3-Diazepin-2-one, hexahydro-5,6-dihydroxy-1,3-bis((4-methoxyphenyl)methyl)-4,7-bis(phenylmethyl)-, (4R,5S,6S,7R)- chemical structure, C35H38N2O5, CAS 153182-39-9
2H-1,3-Diazepin-2-one, hexahydro-5,6-dihydroxy-1,3-bis((4-methoxyphenyl)methyl)-4,7-bis(phenylmethyl)-, (4R,5S,6S,7R)-
CAS 153182-39-9C35H38N2O5
2H-1,3-Diazepin-2-one, hexahydro-5,6-dihydroxy-1,3-bis((3-(hydroxymethyl)phenyl)methyl)-4,7-bis(phenylmethyl)-, (4R,5S,6S,7R)- chemical structure, C35H38N2O5, CAS 153183-11-0
2H-1,3-Diazepin-2-one, hexahydro-5,6-dihydroxy-1,3-bis((3-(hydroxymethyl)phenyl)methyl)-4,7-bis(phenylmethyl)-, (4R,5S,6S,7R)-
CAS 153183-11-0C35H38N2O5
2H-1,3-Diazepin-2-one, hexahydro-5,6-dihydroxy-1,3,4,7-tetrakis(phenylmethyl)-, (4R,5S,6S,7R)- chemical structure, C33H34N2O3, CAS 153223-23-5
2H-1,3-Diazepin-2-one, hexahydro-5,6-dihydroxy-1,3,4,7-tetrakis(phenylmethyl)-, (4R,5S,6S,7R)-
CAS 153223-23-5C33H34N2O3
(4R,5S,6S,7R)-4,7-Dibenzyl-1,3-bis[(3-fluorophenyl)methyl]-5,6-dihydroxy-1,3-diazepan-2-one chemical structure, C33H32F2N2O3, CAS 153182-42-4
(4R,5S,6S,7R)-4,7-Dibenzyl-1,3-bis[(3-fluorophenyl)methyl]-5,6-dihydroxy-1,3-diazepan-2-one
CAS 153182-42-4C33H32F2N2O3
(4R,5S,6S,7R)-4,7-Dibenzyl-1,3-bis[(2-fluorophenyl)methyl]-5,6-dihydroxy-1,3-diazepan-2-one chemical structure, C33H32F2N2O3, CAS 153182-43-5
(4R,5S,6S,7R)-4,7-Dibenzyl-1,3-bis[(2-fluorophenyl)methyl]-5,6-dihydroxy-1,3-diazepan-2-one
CAS 153182-43-5C33H32F2N2O3
(4R,5S,6S,7R)-4,7-Dibenzyl-1,3-bis[(4-fluorophenyl)methyl]-5,6-dihydroxy-1,3-diazepan-2-one chemical structure, C33H32F2N2O3, CAS 153182-30-0
(4R,5S,6S,7R)-4,7-Dibenzyl-1,3-bis[(4-fluorophenyl)methyl]-5,6-dihydroxy-1,3-diazepan-2-one
CAS 153182-30-0C33H32F2N2O3
(4R,5S,6S,7R)-4,7-Dibenzyl-1,3-bis[(2-chlorophenyl)methyl]-5,6-dihydroxy-1,3-diazepan-2-one chemical structure, C33H32Cl2N2O3, CAS 153182-55-9
(4R,5S,6S,7R)-4,7-Dibenzyl-1,3-bis[(2-chlorophenyl)methyl]-5,6-dihydroxy-1,3-diazepan-2-one
CAS 153182-55-9C33H32Cl2N2O3
2H-1,3-Diazepin-2-one, 1,3-bis((3-chlorophenyl)methyl)hexahydro-5,6-dihydroxy-4,7-bis(phenylmethyl)-, (4R,5S,6S,7R)- chemical structure, C33H32Cl2N2O3, CAS 153182-49-1
2H-1,3-Diazepin-2-one, 1,3-bis((3-chlorophenyl)methyl)hexahydro-5,6-dihydroxy-4,7-bis(phenylmethyl)-, (4R,5S,6S,7R)-
CAS 153182-49-1C33H32Cl2N2O3
2H-1,3-Diazepin-2-one, 1,3-bis((4-chlorophenyl)methyl)hexahydro-5,6-dihydroxy-4,7-bis(phenylmethyl)-, (4R,5S,6S,7R)- chemical structure, C33H32Cl2N2O3, CAS 153182-54-8
2H-1,3-Diazepin-2-one, 1,3-bis((4-chlorophenyl)methyl)hexahydro-5,6-dihydroxy-4,7-bis(phenylmethyl)-, (4R,5S,6S,7R)-
CAS 153182-54-8C33H32Cl2N2O3
2H-1,3-Diazepin-2-one, 1,3-bis((4-bromophenyl)methyl)hexahydro-5,6-dihydroxy-4,7-bis(phenylmethyl)-, (4R,5S,6S,7R)- chemical structure, C33H32Br2N2O3, CAS 153182-57-1
2H-1,3-Diazepin-2-one, 1,3-bis((4-bromophenyl)methyl)hexahydro-5,6-dihydroxy-4,7-bis(phenylmethyl)-, (4R,5S,6S,7R)-
CAS 153182-57-1C33H32Br2N2O3
2H-1,3-Diazepin-2-one, 1,3-bis((3-bromophenyl)methyl)hexahydro-5,6-dihydroxy-4,7-bis(phenylmethyl)-, (4R,5S,6S,7R)- chemical structure, C33H32Br2N2O3, CAS 152929-67-4
2H-1,3-Diazepin-2-one, 1,3-bis((3-bromophenyl)methyl)hexahydro-5,6-dihydroxy-4,7-bis(phenylmethyl)-, (4R,5S,6S,7R)-
CAS 152929-67-4C33H32Br2N2O3
2H-1,3-Diazepin-2-one, hexahydro-5,6-dihydroxy-1,3-bis((3-methylphenyl)methyl)-4,7-bis(phenylmethyl)-, (4R,5S,6S,7R)- chemical structure, C35H38N2O3, CAS 153182-52-6
2H-1,3-Diazepin-2-one, hexahydro-5,6-dihydroxy-1,3-bis((3-methylphenyl)methyl)-4,7-bis(phenylmethyl)-, (4R,5S,6S,7R)-
CAS 153182-52-6C35H38N2O3
2H-1,3-Diazepin-2-one, hexahydro-5,6-dihydroxy-1,3-bis((4-methylphenyl)methyl)-4,7-bis(phenylmethyl)-, (4R,5S,6S,7R)- chemical structure, C35H38N2O3, CAS 153182-46-8
2H-1,3-Diazepin-2-one, hexahydro-5,6-dihydroxy-1,3-bis((4-methylphenyl)methyl)-4,7-bis(phenylmethyl)-, (4R,5S,6S,7R)-
CAS 153182-46-8C35H38N2O3
2H-1,3-Diazepin-2-one, hexahydro-5,6-dihydroxy-4,7-bis(phenylmethyl)-1,3-bis((3-(trifluoromethyl)phenyl)methyl)-, (4R,5S,6S,7R)- chemical structure, C35H32F6N2O3, CAS 153182-50-4
2H-1,3-Diazepin-2-one, hexahydro-5,6-dihydroxy-4,7-bis(phenylmethyl)-1,3-bis((3-(trifluoromethyl)phenyl)methyl)-, (4R,5S,6S,7R)-
CAS 153182-50-4C35H32F6N2O3
2H-1,3-Diazepin-2-one, hexahydro-5,6-dihydroxy-4,7-bis(phenylmethyl)-1,3-bis((4-(trifluoromethyl)phenyl)methyl)-, (4R,5S,6S,7R)- chemical structure, C35H32F6N2O3, CAS 153182-48-0
2H-1,3-Diazepin-2-one, hexahydro-5,6-dihydroxy-4,7-bis(phenylmethyl)-1,3-bis((4-(trifluoromethyl)phenyl)methyl)-, (4R,5S,6S,7R)-
CAS 153182-48-0C35H32F6N2O3
2H-1,3-Diazepin-2-one, hexahydro-5,6-dihydroxy-1,3-bis((2-methoxyphenyl)methyl)-4,7-bis(phenylmethyl)-, (4R,5S,6S,7R)- chemical structure, C35H38N2O5, CAS 153182-53-7
2H-1,3-Diazepin-2-one, hexahydro-5,6-dihydroxy-1,3-bis((2-methoxyphenyl)methyl)-4,7-bis(phenylmethyl)-, (4R,5S,6S,7R)-
CAS 153182-53-7C35H38N2O5
Benzamide, 3,3'-(((4R,5S,6S,7R)-tetrahydro-5,6-dihydroxy-2-oxo-4,7-bis(phenylmethyl)-1H-1,3-diazepine-1,3(2H)-diyl)bis(methylene))bis(N-hydroxy- chemical structure, C35H36N4O7, CAS 153183-64-3
Benzamide, 3,3'-(((4R,5S,6S,7R)-tetrahydro-5,6-dihydroxy-2-oxo-4,7-bis(phenylmethyl)-1H-1,3-diazepine-1,3(2H)-diyl)bis(methylene))bis(N-hydroxy-
CAS 153183-64-3C35H36N4O7
Benzamide, 3,3'-(((4R,5S,6S,7R)-tetrahydro-5,6-dihydroxy-2-oxo-4,7-bis(phenylmethyl)-1H-1,3-diazepine-1,3(2H)-diyl)bis(methylene))bis(N-methoxy- chemical structure, C37H40N4O7, CAS 153183-60-9
Benzamide, 3,3'-(((4R,5S,6S,7R)-tetrahydro-5,6-dihydroxy-2-oxo-4,7-bis(phenylmethyl)-1H-1,3-diazepine-1,3(2H)-diyl)bis(methylene))bis(N-methoxy-
CAS 153183-60-9C37H40N4O7
Benzamide, 3,3'-(((4R,5S,6S,7R)-tetrahydro-5,6-dihydroxy-2-oxo-4,7-bis(phenylmethyl)-1H-1,3-diazepine-1,3(2H)-diyl)bis(methylene))bis(N-methyl- chemical structure, C37H40N4O5, CAS 152928-55-7
Benzamide, 3,3'-(((4R,5S,6S,7R)-tetrahydro-5,6-dihydroxy-2-oxo-4,7-bis(phenylmethyl)-1H-1,3-diazepine-1,3(2H)-diyl)bis(methylene))bis(N-methyl-
CAS 152928-55-7C37H40N4O5
Benzamide, 3,3'-(((4R,5S,6S,7R)-tetrahydro-5,6-dihydroxy-2-oxo-4,7-bis(phenylmethyl)-1H-1,3-diazepine-1,3(2H)-diyl)bis(methylene))bis(N-ethyl- chemical structure, C39H44N4O5, CAS 152928-65-9
Benzamide, 3,3'-(((4R,5S,6S,7R)-tetrahydro-5,6-dihydroxy-2-oxo-4,7-bis(phenylmethyl)-1H-1,3-diazepine-1,3(2H)-diyl)bis(methylene))bis(N-ethyl-
CAS 152928-65-9C39H44N4O5
Benzamide, 3,3'-(((4R,5S,6S,7R)-tetrahydro-5,6-dihydroxy-2-oxo-4,7-bis(phenylmethyl)-1H-1,3-diazepine-1,3(2H)-diyl)bis(methylene))bis(N-(1-methylethyl)- chemical structure, C41H48N4O5, CAS 183860-42-6
Benzamide, 3,3'-(((4R,5S,6S,7R)-tetrahydro-5,6-dihydroxy-2-oxo-4,7-bis(phenylmethyl)-1H-1,3-diazepine-1,3(2H)-diyl)bis(methylene))bis(N-(1-methylethyl)-
CAS 183860-42-6C41H48N4O5