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Murcko scaffold

5-Oxo-N-(5-((2-oxo-2-(phenylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)-1-phenylpyrrolidine-3-carboxamide scaffold

13 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 31
Chemicals: 13
With full pages: 3

Scaffold SMILES

O=C(CSc1nnc(NC(=O)C2CC(=O)N(c3ccccc3)C2)s1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 5-Oxo-N-(5-((2-oxo-2-(phenylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)-1-phenylpyrrolidine-3-carboxamide page

Murcko scaffold O=C(CSc1nnc(NC(=O)C2CC(=O)N(c3ccccc3)C2)s1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

N-[5-[2-(4-Fluoroanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-5-oxo-1-phenylpyrrolidine-3-carboxamide chemical structure, C21H18FN5O3S2, CAS 835895-92-6

N-[5-[2-(4-Fluoroanilino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]-5-oxo-1-phenylpyrrolidine-3-carboxamide

CAS 835895-92-6C₂₁H₁₈FN₅O₃S₂

N-(5-((2-(Methyl(phenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-5-oxo-1-phenylpyrrolidine-3-carboxamide chemical structure, C22H21N5O3S2, CAS 872594-60-0

N-(5-((2-(Methyl(phenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-5-oxo-1-phenylpyrrolidine-3-carboxamide

CAS 872594-60-0C₂₂H₂₁N₅O₃S₂

5-Oxo-N-(5-((2-oxo-2-(phenylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)-1-phenylpyrrolidine-3-carboxamide chemical structure, C21H19N5O3S2, CAS 872594-63-3

5-Oxo-N-(5-((2-oxo-2-(phenylamino)ethyl)thio)-1,3,4-thiadiazol-2-yl)-1-phenylpyrrolidine-3-carboxamide

CAS 872594-63-3C₂₁H₁₉N₅O₃S₂

N-(5-((2-((4-Acetylphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-5-oxo-1-phenylpyrrolidine-3-carboxamide chemical structure, C23H21N5O4S2, CAS 872594-65-5

N-(5-((2-((4-Acetylphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-5-oxo-1-phenylpyrrolidine-3-carboxamide

CAS 872594-65-5C₂₃H₂₁N₅O₄S₂

N-(5-((2-((4-Carbamoylphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-5-oxo-1-phenylpyrrolidine-3-carboxamide chemical structure, C22H20N6O4S2, CAS 872594-70-2

N-(5-((2-((4-Carbamoylphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-5-oxo-1-phenylpyrrolidine-3-carboxamide

CAS 872594-70-2C₂₂H₂₀N₆O₄S₂

N-(5-((2-((4-Carbamoylphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-1-(2-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C23H22N6O5S2, CAS 897758-56-4

N-(5-((2-((4-Carbamoylphenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-1-(2-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide

CAS 897758-56-4C₂₃H₂₂N₆O₅S₂

N-[5-({[(4-Acetamidophenyl)carbamoyl]methyl}sulfanyl)-1,3,4-thiadiazol-2-yl]-1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C23H21FN6O4S2, CAS 921063-19-6

N-[5-({[(4-Acetamidophenyl)carbamoyl]methyl}sulfanyl)-1,3,4-thiadiazol-2-yl]-1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxamide

CAS 921063-19-6C₂₃H₂₁FN₆O₄S₂

N-[5-({[(4-Acetamidophenyl)carbamoyl]methyl}sulfanyl)-1,3,4-thiadiazol-2-yl]-1-(3-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C24H24N6O5S2, CAS 920464-05-7

N-[5-({[(4-Acetamidophenyl)carbamoyl]methyl}sulfanyl)-1,3,4-thiadiazol-2-yl]-1-(3-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide

CAS 920464-05-7C₂₄H₂₄N₆O₅S₂

N-[5-({[(4-Acetamidophenyl)carbamoyl]methyl}sulfanyl)-1,3,4-thiadiazol-2-yl]-5-oxo-1-phenylpyrrolidine-3-carboxamide chemical structure, C23H22N6O4S2, CAS 920482-32-2

N-[5-({[(4-Acetamidophenyl)carbamoyl]methyl}sulfanyl)-1,3,4-thiadiazol-2-yl]-5-oxo-1-phenylpyrrolidine-3-carboxamide

CAS 920482-32-2C₂₃H₂₂N₆O₄S₂

N-(5-((2-((4-Acetamidophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C24H24N6O5S2, CAS 920465-24-3

N-(5-((2-((4-Acetamidophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide

CAS 920465-24-3C₂₄H₂₄N₆O₅S₂

1-(4-Fluorophenyl)-N-(5-((2-((4-nitrophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-5-oxopyrrolidine-3-carboxamide chemical structure, C21H17FN6O5S2, CAS 920466-08-6

1-(4-Fluorophenyl)-N-(5-((2-((4-nitrophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-5-oxopyrrolidine-3-carboxamide

CAS 920466-08-6C₂₁H₁₇FN₆O₅S₂

N-(5-((2-((4-Acetamidophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-5-oxo-1-(p-tolyl)pyrrolidine-3-carboxamide chemical structure, C24H24N6O4S2, CAS 921147-64-0

N-(5-((2-((4-Acetamidophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-5-oxo-1-(p-tolyl)pyrrolidine-3-carboxamide

CAS 921147-64-0C₂₄H₂₄N₆O₄S₂

N-(5-((2-((3-Acetamidophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C24H24N6O5S2, CAS 920488-34-2

N-(5-((2-((3-Acetamidophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide

CAS 920488-34-2C₂₄H₂₄N₆O₅S₂