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Murcko scaffold

Ring system with 4 rings and 24 atoms

11 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
11
With full pages
5
Scaffold SMILES

c1ccc(-c2cc(N3CCNCC3)nc(-c3ccccc3)n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2cc(N3CCNCC3)nc(-c3ccccc3)n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 11 of 11 chemicals

4-(4-Methoxyphenyl)-2-(4-methylphenyl)-6-(4-methylpiperazin-1-yl)pyrimidine-5-carbonitrile chemical structure, C24H25N5O, CAS 400081-15-4
4-(4-Methoxyphenyl)-2-(4-methylphenyl)-6-(4-methylpiperazin-1-yl)pyrimidine-5-carbonitrile
CAS 400081-15-4C24H25N5O
4-(4-Chlorophenyl)-6-(4-methylpiperazino)-2-phenyl-5-pyrimidinecarbonitrile chemical structure, C22H20ClN5, CAS 320418-13-1
4-(4-Chlorophenyl)-6-(4-methylpiperazino)-2-phenyl-5-pyrimidinecarbonitrile
CAS 320418-13-1C22H20ClN5
4-(4-Methylpiperazino)-2,6-diphenyl-5-pyrimidinecarbonitrile chemical structure, C22H21N5, CAS 320418-29-9
4-(4-Methylpiperazino)-2,6-diphenyl-5-pyrimidinecarbonitrile
CAS 320418-29-9C22H21N5
4-(4-Methoxyphenyl)-2-(3-methylphenyl)-6-(4-methylpiperazino)-5-pyrimidinecarbonitrile chemical structure, C24H25N5O, CAS 477859-04-4
4-(4-Methoxyphenyl)-2-(3-methylphenyl)-6-(4-methylpiperazino)-5-pyrimidinecarbonitrile
CAS 477859-04-4C24H25N5O
4-(3-Methoxyphenyl)-6-(4-methylpiperazino)-2-phenyl-5-pyrimidinecarbonitrile chemical structure, C23H23N5O, CAS 477853-89-7
4-(3-Methoxyphenyl)-6-(4-methylpiperazino)-2-phenyl-5-pyrimidinecarbonitrile
CAS 477853-89-7C23H23N5O
4-(4-Methylphenyl)-6-(4-methylpiperazino)-2-phenyl-5-pyrimidinecarbonitrile chemical structure, C23H23N5, CAS 477853-92-2
4-(4-Methylphenyl)-6-(4-methylpiperazino)-2-phenyl-5-pyrimidinecarbonitrile
CAS 477853-92-2C23H23N5
4-(4-Fluorophenyl)-6-(4-methylpiperazino)-2-phenyl-5-pyrimidinecarbonitrile chemical structure, C22H20FN5, CAS 477853-94-4
4-(4-Fluorophenyl)-6-(4-methylpiperazino)-2-phenyl-5-pyrimidinecarbonitrile
CAS 477853-94-4C22H20FN5
4-(2-Methoxyphenyl)-6-(4-methylpiperazino)-2-phenyl-5-pyrimidinecarbonitrile chemical structure, C23H23N5O, CAS 477853-98-8
4-(2-Methoxyphenyl)-6-(4-methylpiperazino)-2-phenyl-5-pyrimidinecarbonitrile
CAS 477853-98-8C23H23N5O
4-(4-Methoxyphenyl)-6-(4-methylpiperazino)-2-phenyl-5-pyrimidinecarbonitrile chemical structure, C23H23N5O, CAS 338395-07-6
4-(4-Methoxyphenyl)-6-(4-methylpiperazino)-2-phenyl-5-pyrimidinecarbonitrile
CAS 338395-07-6C23H23N5O
2-(3-Chlorophenyl)-4-(4-methoxyphenyl)-6-(4-methylpiperazin-1-yl)pyrimidine-5-carbonitrile chemical structure, C23H22ClN5O, CAS 477873-09-9
2-(3-Chlorophenyl)-4-(4-methoxyphenyl)-6-(4-methylpiperazin-1-yl)pyrimidine-5-carbonitrile
CAS 477873-09-9C23H22ClN5O
2-(4-Chlorophenyl)-4-(4-methoxyphenyl)-6-(4-methylpiperazin-1-yl)pyrimidine-5-carbonitrile chemical structure, C23H22ClN5O, CAS 400079-40-5
2-(4-Chlorophenyl)-4-(4-methoxyphenyl)-6-(4-methylpiperazin-1-yl)pyrimidine-5-carbonitrile
CAS 400079-40-5C23H22ClN5O