Murcko scaffold
5-Benzyl-2,3-diphenyldihydro-2H-pyrrolo[3,4-d]isoxazole-4,6(5H,6aH)-dione scaffold
22 chemicals on CompoundList share this ring system.
- Rings
- 5
- Scaffold atoms
- 29
- Chemicals
- 22
- With full pages
- 7
Scaffold SMILES
O=C1C2ON(c3ccccc3)C(c3ccccc3)C2C(=O)N1Cc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 22 of 22 chemicals
![5-Benzyl-3-(4-fluorophenyl)-2-phenyldihydro-2H-pyrrolo[3,4-d]isoxazole-4,6(5H,6aH)-dione chemical structure, C24H19FN2O3, CAS 312605-63-3](/s/JEECXSKHSNMNKW-UHFFFAOYSA-N.svg)
5-Benzyl-3-(4-fluorophenyl)-2-phenyldihydro-2H-pyrrolo[3,4-d]isoxazole-4,6(5H,6aH)-dione
CAS 312605-63-3C24H19FN2O3
![5-Benzyl-3-(4-methoxyphenyl)-2-phenyldihydro-2H-pyrrolo[3,4-d]isoxazole-4,6(3H,5H)-dione chemical structure, C25H22N2O4, CAS 256955-57-4](/s/DMRCQKATQIAHDF-UHFFFAOYSA-N.svg)
5-Benzyl-3-(4-methoxyphenyl)-2-phenyldihydro-2H-pyrrolo[3,4-d]isoxazole-4,6(3H,5H)-dione
CAS 256955-57-4C25H22N2O4
![5-Benzyl-2-(4-chlorophenyl)-3-(4-fluorophenyl)dihydro-2H-pyrrolo[3,4-d]isoxazole-4,6(3H,5H)-dione chemical structure, C24H18ClFN2O3, CAS 352665-95-3](/s/FLZQMQNJFHDFPB-UHFFFAOYSA-N.svg)
5-Benzyl-2-(4-chlorophenyl)-3-(4-fluorophenyl)dihydro-2H-pyrrolo[3,4-d]isoxazole-4,6(3H,5H)-dione
CAS 352665-95-3C24H18ClFN2O3
![5-Benzyl-3-(4-hydroxy-3-methoxyphenyl)-2-phenyl-3a,6a-dihydro-3H-pyrrolo[3,4-d][1,2]oxazole-4,6-dione chemical structure, C25H22N2O5, CAS 470695-37-5](/s/QYWBKOWNJPKBRR-UHFFFAOYSA-N.svg)
5-Benzyl-3-(4-hydroxy-3-methoxyphenyl)-2-phenyl-3a,6a-dihydro-3H-pyrrolo[3,4-d][1,2]oxazole-4,6-dione
CAS 470695-37-5C25H22N2O5
![5-Benzyl-3-(4-nitrophenyl)-2-phenyldihydro-2H-pyrrolo[3,4-d][1,2]oxazole-4,6(3H,5H)-dione chemical structure, C24H19N3O5, CAS 5808-71-9](/s/ILTXKNHWZXTCFB-UHFFFAOYSA-N.svg)
5-Benzyl-3-(4-nitrophenyl)-2-phenyldihydro-2H-pyrrolo[3,4-d][1,2]oxazole-4,6(3H,5H)-dione
CAS 5808-71-9C24H19N3O5
![5-Benzyl-2,3-diphenyldihydro-2H-pyrrolo[3,4-d]isoxazole-4,6(5H,6aH)-dione chemical structure, C24H20N2O3, CAS 355115-13-8](/s/PEJXTLNZRZRCNI-UHFFFAOYSA-N.svg)
5-Benzyl-2,3-diphenyldihydro-2H-pyrrolo[3,4-d]isoxazole-4,6(5H,6aH)-dione
CAS 355115-13-8C24H20N2O3
![5-Benzyl-3-(4-fluorophenyl)-2-(o-tolyl)dihydro-2H-pyrrolo[3,4-d]isoxazole-4,6(5H,6aH)-dione chemical structure, C25H21FN2O3, CAS 355115-37-6](/s/HJUZSVABEJEWRC-UHFFFAOYSA-N.svg)
5-Benzyl-3-(4-fluorophenyl)-2-(o-tolyl)dihydro-2H-pyrrolo[3,4-d]isoxazole-4,6(5H,6aH)-dione
CAS 355115-37-6C25H21FN2O3
![5-Benzyl-2-(4-chlorophenyl)-3-phenyldihydro-2H-pyrrolo[3,4-d][1,2]oxazole-4,6(3H,5H)-dione chemical structure, C24H19ClN2O3, CAS 473390-99-7](/s/FGVLDTYEWGAEDI-UHFFFAOYSA-N.svg)
5-Benzyl-2-(4-chlorophenyl)-3-phenyldihydro-2H-pyrrolo[3,4-d][1,2]oxazole-4,6(3H,5H)-dione
CAS 473390-99-7C24H19ClN2O3
![5-Benzyl-3-(3-nitrophenyl)-2-phenyldihydro-2H-pyrrolo[3,4-d]isoxazole-4,6(5H,6aH)-dione chemical structure, C24H19N3O5, CAS 6077-41-4](/s/JZKWMYLBDZSCOC-UHFFFAOYSA-N.svg)
5-Benzyl-3-(3-nitrophenyl)-2-phenyldihydro-2H-pyrrolo[3,4-d]isoxazole-4,6(5H,6aH)-dione
CAS 6077-41-4C24H19N3O5
![5-Benzyl-2-(4-chlorophenyl)-3-(4-(trifluoromethyl)phenyl)dihydro-2H-pyrrolo[3,4-d]isoxazole-4,6(5H,6aH)-dione chemical structure, C25H18ClF3N2O3, CAS 473444-93-8](/s/GHNHHSUJFYEXIG-UHFFFAOYSA-N.svg)
5-Benzyl-2-(4-chlorophenyl)-3-(4-(trifluoromethyl)phenyl)dihydro-2H-pyrrolo[3,4-d]isoxazole-4,6(5H,6aH)-dione
CAS 473444-93-8C25H18ClF3N2O3
![5-Benzyl-2-(4-chlorophenyl)-3-(4-(methylthio)phenyl)dihydro-2H-pyrrolo[3,4-d]isoxazole-4,6(5H,6aH)-dione chemical structure, C25H21ClN2O3S, CAS 353793-17-6](/s/XAFDVTZFXFYEQN-UHFFFAOYSA-N.svg)
5-Benzyl-2-(4-chlorophenyl)-3-(4-(methylthio)phenyl)dihydro-2H-pyrrolo[3,4-d]isoxazole-4,6(5H,6aH)-dione
CAS 353793-17-6C25H21ClN2O3S
![5-Benzyl-3-(3-hydroxy-4-methoxyphenyl)-2-phenyldihydro-2H-pyrrolo[3,4-d]isoxazole-4,6(5H,6aH)-dione chemical structure, C25H22N2O5, CAS 473707-83-4](/s/LEBSQAFYDAPXJL-UHFFFAOYSA-N.svg)
5-Benzyl-3-(3-hydroxy-4-methoxyphenyl)-2-phenyldihydro-2H-pyrrolo[3,4-d]isoxazole-4,6(5H,6aH)-dione
CAS 473707-83-4C25H22N2O5
![5-Benzyl-3-(4-(difluoromethoxy)phenyl)-2-phenyldihydro-2H-pyrrolo[3,4-d]isoxazole-4,6(5H,6aH)-dione chemical structure, C25H20F2N2O4, CAS 1005272-88-7](/s/WJIBTSVQFRQWPY-UHFFFAOYSA-N.svg)
5-Benzyl-3-(4-(difluoromethoxy)phenyl)-2-phenyldihydro-2H-pyrrolo[3,4-d]isoxazole-4,6(5H,6aH)-dione
CAS 1005272-88-7C25H20F2N2O4
![Methyl 4-(5-benzyl-4,6-dioxo-2-phenylhexahydro-2H-pyrrolo[3,4-d]isoxazol-3-yl)benzoate chemical structure, C26H22N2O5, CAS 1005272-87-6](/s/XDXJZBUCGIEITE-UHFFFAOYSA-N.svg)
Methyl 4-(5-benzyl-4,6-dioxo-2-phenylhexahydro-2H-pyrrolo[3,4-d]isoxazol-3-yl)benzoate
CAS 1005272-87-6C26H22N2O5
5-Benzyl-3-(4-(dimethylamino)phenyl)-2-phenyldihydro-2H-pyrrolo(3,4-D)isoxazole-4,6(3H,5H)-dione
CAS 308101-48-6C26H25N3O3
![3-(2,4-Dichlorophenyl)-2-phenyl-5-(phenylmethyl)dihydro-2H-pyrrolo[3,4-d]isoxazole-4,6(3H,5H)-dione chemical structure, C24H18Cl2N2O3, CAS 301851-54-7](/s/AUSUEGIFSCMRMD-UHFFFAOYSA-N.svg)
3-(2,4-Dichlorophenyl)-2-phenyl-5-(phenylmethyl)dihydro-2H-pyrrolo[3,4-d]isoxazole-4,6(3H,5H)-dione
CAS 301851-54-7C24H18Cl2N2O3
![5-Benzyl-3-(4-bromophenyl)-2-phenyldihydro-2H-pyrrolo[3,4-d]isoxazole-4,6(5H,6aH)-dione chemical structure, C24H19BrN2O3, CAS 1005183-08-3](/s/LMSKLLAADBTPBF-UHFFFAOYSA-N.svg)
5-Benzyl-3-(4-bromophenyl)-2-phenyldihydro-2H-pyrrolo[3,4-d]isoxazole-4,6(5H,6aH)-dione
CAS 1005183-08-3C24H19BrN2O3
![5-Benzyl-2-phenyl-3-[4-(trifluoromethoxy)phenyl]dihydro-2H-pyrrolo[3,4-d][1,2]oxazole-4,6(3H,5H)-dione chemical structure, C25H19F3N2O4, CAS 1023208-73-2](/s/AFNZTVBMNIRERZ-UHFFFAOYSA-N.svg)
5-Benzyl-2-phenyl-3-[4-(trifluoromethoxy)phenyl]dihydro-2H-pyrrolo[3,4-d][1,2]oxazole-4,6(3H,5H)-dione
CAS 1023208-73-2C25H19F3N2O4
![5-Benzyl-3-(3-bromo-4-hydroxy-5-methoxyphenyl)-2-(3-nitrophenyl)dihydro-2H-pyrrolo[3,4-d][1,2]oxazole-4,6(3H,5H)-dione chemical structure, C25H20BrN3O7, CAS 1024312-24-0](/s/KDQRKIRJGGNYDL-UHFFFAOYSA-N.svg)
5-Benzyl-3-(3-bromo-4-hydroxy-5-methoxyphenyl)-2-(3-nitrophenyl)dihydro-2H-pyrrolo[3,4-d][1,2]oxazole-4,6(3H,5H)-dione
CAS 1024312-24-0C25H20BrN3O7
![5-Benzyl-3-(3-bromo-5-ethoxy-4-hydroxyphenyl)-2-(3-nitrophenyl)dihydro-2H-pyrrolo[3,4-d][1,2]oxazole-4,6(3H,5H)-dione chemical structure, C26H22BrN3O7, CAS 1024306-10-2](/s/YTGUMACEWQRQPH-UHFFFAOYSA-N.svg)
5-Benzyl-3-(3-bromo-5-ethoxy-4-hydroxyphenyl)-2-(3-nitrophenyl)dihydro-2H-pyrrolo[3,4-d][1,2]oxazole-4,6(3H,5H)-dione
CAS 1024306-10-2C26H22BrN3O7
![5-Benzyl-3-(4-chlorophenyl)-2-(p-tolyl)dihydro-2H-pyrrolo[3,4-d]isoxazole-4,6(5H,6aH)-dione chemical structure, C25H21ClN2O3, CAS 1005271-17-9](/s/PMGVEKQRRLEQFH-UHFFFAOYSA-N.svg)
5-Benzyl-3-(4-chlorophenyl)-2-(p-tolyl)dihydro-2H-pyrrolo[3,4-d]isoxazole-4,6(5H,6aH)-dione
CAS 1005271-17-9C25H21ClN2O3
![Methyl 4-[5-benzyl-2-(4-chlorophenyl)-4,6-dioxo-hexahydro-2H-pyrrolo[3,4-d][1,2]oxazol-3-yl]benzoate chemical structure, C26H21ClN2O5, CAS 1005271-21-5](/s/AKSBUIYBTCXUBN-UHFFFAOYSA-N.svg)
Methyl 4-[5-benzyl-2-(4-chlorophenyl)-4,6-dioxo-hexahydro-2H-pyrrolo[3,4-d][1,2]oxazol-3-yl]benzoate
CAS 1005271-21-5C26H21ClN2O5