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Murcko scaffold

Ring system with 4 rings and 29 atoms

20 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
29
Chemicals
20
With full pages
14
Scaffold SMILES

O=C(CSc1nnc(COc2ccccc2)n1-c1ccccc1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nnc(COc2ccccc2)n1-c1ccccc1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 20 of 20 chemicals

1-(4-Methoxyphenyl)-2-{[5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl}ethanone chemical structure, C24H21N3O3S, CAS 353789-30-7
1-(4-Methoxyphenyl)-2-{[5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl}ethanone
CAS 353789-30-7C24H21N3O3S
2-[[5-[(4-Chlorophenoxy)methyl]-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methoxyphenyl)ethanone chemical structure, C24H20ClN3O3S, CAS 332948-57-9
2-[[5-[(4-Chlorophenoxy)methyl]-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methoxyphenyl)ethanone
CAS 332948-57-9C24H20ClN3O3S
1-(3-Nitrophenyl)-2-[[5-(phenoxymethyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]ethanone chemical structure, C23H18N4O4S, CAS 312289-26-2
1-(3-Nitrophenyl)-2-[[5-(phenoxymethyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]ethanone
CAS 312289-26-2C23H18N4O4S
2-[[5-[(2-Methoxyphenoxy)methyl]-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]-1-(4-nitrophenyl)ethanone chemical structure, C24H20N4O5S, CAS 712333-62-5
2-[[5-[(2-Methoxyphenoxy)methyl]-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]-1-(4-nitrophenyl)ethanone
CAS 712333-62-5C24H20N4O5S
1-(4-Chlorophenyl)-2-({5-[(2,4-dichlorophenoxy)methyl]-4-phenyl-4H-1,2,4-triazol-3-yl}sulfanyl)ethanone chemical structure, C23H16Cl3N3O2S, CAS 326882-35-3
1-(4-Chlorophenyl)-2-({5-[(2,4-dichlorophenoxy)methyl]-4-phenyl-4H-1,2,4-triazol-3-yl}sulfanyl)ethanone
CAS 326882-35-3C23H16Cl3N3O2S
2-((5-((2,4-Dichlorophenoxy)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-1-(3-nitrophenyl)ethanone chemical structure, C23H16Cl2N4O4S, CAS 326882-18-2
2-((5-((2,4-Dichlorophenoxy)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-1-(3-nitrophenyl)ethanone
CAS 326882-18-2C23H16Cl2N4O4S
1-(4-BR-PH)-2-((5-(Phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)ethanone chemical structure, C23H18BrN3O2S, CAS 129544-93-0
1-(4-BR-PH)-2-((5-(Phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)ethanone
CAS 129544-93-0C23H18BrN3O2S
2-[[5-[(2-Methoxyphenoxy)methyl]-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]-1-(3-nitrophenyl)ethanone chemical structure, C24H20N4O5S, CAS 767327-28-6
2-[[5-[(2-Methoxyphenoxy)methyl]-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]-1-(3-nitrophenyl)ethanone
CAS 767327-28-6C24H20N4O5S
2-((5-((2,4-Dichlorophenoxy)methyl)-4-(2-methylphenyl)-4H-1,2,4-triazol-3-yl)sulfanyl)-1-phenylethanone chemical structure, C24H19Cl2N3O2S, CAS 538337-80-3
2-((5-((2,4-Dichlorophenoxy)methyl)-4-(2-methylphenyl)-4H-1,2,4-triazol-3-yl)sulfanyl)-1-phenylethanone
CAS 538337-80-3C24H19Cl2N3O2S
1-(4-Bromophenyl)-2-({5-[(4-methoxyphenoxy)methyl]-4-phenyl-4H-1,2,4-triazol-3-YL}sulfanyl)ethanone chemical structure, C24H20BrN3O3S, CAS 618441-23-9
1-(4-Bromophenyl)-2-({5-[(4-methoxyphenoxy)methyl]-4-phenyl-4H-1,2,4-triazol-3-YL}sulfanyl)ethanone
CAS 618441-23-9C24H20BrN3O3S
2-({4-(2-Bromophenyl)-5-[(4-methylphenoxy)methyl]-4H-1,2,4-triazol-3-YL}sulfanyl)-1-(4-methoxyphenyl)ethanone chemical structure, C25H22BrN3O3S, CAS 618441-29-5
2-({4-(2-Bromophenyl)-5-[(4-methylphenoxy)methyl]-4H-1,2,4-triazol-3-YL}sulfanyl)-1-(4-methoxyphenyl)ethanone
CAS 618441-29-5C25H22BrN3O3S
2-({4-(2-Bromophenyl)-5-[(4-methylphenoxy)methyl]-4H-1,2,4-triazol-3-YL}sulfanyl)-1-(4-methylphenyl)ethanone chemical structure, C25H22BrN3O2S, CAS 618441-30-8
2-({4-(2-Bromophenyl)-5-[(4-methylphenoxy)methyl]-4H-1,2,4-triazol-3-YL}sulfanyl)-1-(4-methylphenyl)ethanone
CAS 618441-30-8C25H22BrN3O2S
1-(4-Bromophenyl)-2-({4-(2-bromophenyl)-5-[(4-methylphenoxy)methyl]-4H-1,2,4-triazol-3-YL}sulfanyl)ethanone chemical structure, C24H19Br2N3O2S, CAS 618441-31-9
1-(4-Bromophenyl)-2-({4-(2-bromophenyl)-5-[(4-methylphenoxy)methyl]-4H-1,2,4-triazol-3-YL}sulfanyl)ethanone
CAS 618441-31-9C24H19Br2N3O2S
2-((4-(2-Bromophenyl)-5-((4-methylphenoxy)methyl)-4H-1,2,4-triazol-3-yl)sulfanyl)-1-(4-ethoxyphenyl)ethanone chemical structure, C26H24BrN3O3S, CAS 618441-32-0
2-((4-(2-Bromophenyl)-5-((4-methylphenoxy)methyl)-4H-1,2,4-triazol-3-yl)sulfanyl)-1-(4-ethoxyphenyl)ethanone
CAS 618441-32-0C26H24BrN3O3S
2-({4-(2-Bromophenyl)-5-[(4-methylphenoxy)methyl]-4H-1,2,4-triazol-3-YL}sulfanyl)-1-(3-nitrophenyl)ethanone chemical structure, C24H19BrN4O4S, CAS 618441-34-2
2-({4-(2-Bromophenyl)-5-[(4-methylphenoxy)methyl]-4H-1,2,4-triazol-3-YL}sulfanyl)-1-(3-nitrophenyl)ethanone
CAS 618441-34-2C24H19BrN4O4S
2-((4-(2-Bromophenyl)-5-((4-methylphenoxy)methyl)-4H-1,2,4-triazol-3-yl)sulfanyl)-1-(4-chlorophenyl)ethanone chemical structure, C24H19BrClN3O2S, CAS 618441-36-4
2-((4-(2-Bromophenyl)-5-((4-methylphenoxy)methyl)-4H-1,2,4-triazol-3-yl)sulfanyl)-1-(4-chlorophenyl)ethanone
CAS 618441-36-4C24H19BrClN3O2S
2-[[5-[(4-Bromophenoxy)methyl]-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methoxyphenyl)ethanone chemical structure, C24H20BrN3O3S, CAS 325996-15-4
2-[[5-[(4-Bromophenoxy)methyl]-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]-1-(4-methoxyphenyl)ethanone
CAS 325996-15-4C24H20BrN3O3S
1-(4-(Difluoromethoxy)phenyl)-2-((5-((2-isopropyl-5-methylphenoxy)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)ethanone chemical structure, C28H27F2N3O3S, CAS 397276-34-5
1-(4-(Difluoromethoxy)phenyl)-2-((5-((2-isopropyl-5-methylphenoxy)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)ethanone
CAS 397276-34-5C28H27F2N3O3S
2-((5-((2,4-Dichlorophenoxy)methyl)-4-(2-methylphenyl)-4H-1,2,4-triazol-3-yl)sulfanyl)-1-(4-methylphenyl)ethanone chemical structure, C25H21Cl2N3O2S, CAS 538337-79-0
2-((5-((2,4-Dichlorophenoxy)methyl)-4-(2-methylphenyl)-4H-1,2,4-triazol-3-yl)sulfanyl)-1-(4-methylphenyl)ethanone
CAS 538337-79-0C25H21Cl2N3O2S
1-(4-Bromophenyl)-2-((5-((2-isopropyl-5-methylphenoxy)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)ethanone chemical structure, C27H26BrN3O2S, CAS 397276-25-4
1-(4-Bromophenyl)-2-((5-((2-isopropyl-5-methylphenoxy)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)ethanone
CAS 397276-25-4C27H26BrN3O2S