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Murcko scaffold

Ring system with 4 rings and 20 atoms

9 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
20
Chemicals
9
With full pages
3
Scaffold SMILES

O=C1NC(=S)SC1=C1C(=O)N2CC=Cc3cccc1c32

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1NC(=S)SC1=C1C(=O)N2CC=Cc3cccc1c32

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

4,4,6,8-Tetramethyl-1-(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-4H-pyrrolo[3,2,1-ij]quinolin-2(1H)-one chemical structure, C18H16N2O2S2, CAS 587012-28-0
4,4,6,8-Tetramethyl-1-(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-4H-pyrrolo[3,2,1-ij]quinolin-2(1H)-one
CAS 587012-28-0C18H16N2O2S2
(1Z)-8-Ethoxy-4,4,6-trimethyl-1-(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-4H-pyrrolo[3,2,1-ij]quinolin-2(1H)-one chemical structure, C19H18N2O3S2, CAS 674355-09-0
(1Z)-8-Ethoxy-4,4,6-trimethyl-1-(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-4H-pyrrolo[3,2,1-ij]quinolin-2(1H)-one
CAS 674355-09-0C19H18N2O3S2
(Z)-3-Ethyl-5-(8-ethyl-4,4,6-trimethyl-2-oxo-2,4-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-ylidene)-2-thioxothiazolidin-4-one chemical structure, C21H22N2O2S2, CAS 669746-48-9
(Z)-3-Ethyl-5-(8-ethyl-4,4,6-trimethyl-2-oxo-2,4-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-ylidene)-2-thioxothiazolidin-4-one
CAS 669746-48-9C21H22N2O2S2
(1Z)-4,4,6-Trimethyl-2-oxo-1-(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-8-yl acetate chemical structure, C19H16N2O4S2, CAS 650592-87-3
(1Z)-4,4,6-Trimethyl-2-oxo-1-(4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-8-yl acetate
CAS 650592-87-3C19H16N2O4S2
(1Z)-1-(3-Ethyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-4,4,6-trimethyl-2-oxo-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-8-yl acetate chemical structure, C21H20N2O4S2, CAS 1164463-66-4
(1Z)-1-(3-Ethyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-4,4,6-trimethyl-2-oxo-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-8-yl acetate
CAS 1164463-66-4C21H20N2O4S2
(1Z)-1-(3-Ethyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-8-methoxy-4,4,6-trimethyl-4H-pyrrolo[3,2,1-ij]quinolin-2(1H)-one chemical structure, C20H20N2O3S2, CAS 696631-97-7
(1Z)-1-(3-Ethyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-8-methoxy-4,4,6-trimethyl-4H-pyrrolo[3,2,1-ij]quinolin-2(1H)-one
CAS 696631-97-7C20H20N2O3S2
8-Methoxy-4,4,6-trimethyl-1-[4-oxo-2-thioxo-thiazolidin-(5Z)-ylidene]-1H,4H-pyrrolo[3,2,1-ij]quinolin-2-one chemical structure, C18H16N2O3S2, CAS 1164519-94-1
8-Methoxy-4,4,6-trimethyl-1-[4-oxo-2-thioxo-thiazolidin-(5Z)-ylidene]-1H,4H-pyrrolo[3,2,1-ij]quinolin-2-one
CAS 1164519-94-1C18H16N2O3S2
(1Z)-8-Ethoxy-1-(3-ethyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-4,4,6-trimethyl-4H-pyrrolo[3,2,1-ij]quinolin-2(1H)-one chemical structure, C21H22N2O3S2, CAS 724778-80-7
(1Z)-8-Ethoxy-1-(3-ethyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-4,4,6-trimethyl-4H-pyrrolo[3,2,1-ij]quinolin-2(1H)-one
CAS 724778-80-7C21H22N2O3S2
(1Z)-1-(3-Ethyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-4,4,6,8-tetramethyl-4H-pyrrolo[3,2,1-ij]quinolin-2(1H)-one chemical structure, C20H20N2O2S2, CAS 724779-20-8
(1Z)-1-(3-Ethyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-4,4,6,8-tetramethyl-4H-pyrrolo[3,2,1-ij]quinolin-2(1H)-one
CAS 724779-20-8C20H20N2O2S2