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Murcko scaffold

Ring system with 4 rings and 21 atoms

12 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
21
Chemicals
12
With full pages
1
Scaffold SMILES

c1ccc(C2CC(c3cccc4ccccc34)=NO2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(C2CC(c3cccc4ccccc34)=NO2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

Isoxazole, 4,5-dihydro-5-(4-methoxyphenyl)-5-methyl-3-(1-naphthalenyl)- chemical structure, C21H19NO2, CAS 653601-95-7
Isoxazole, 4,5-dihydro-5-(4-methoxyphenyl)-5-methyl-3-(1-naphthalenyl)-
CAS 653601-95-7C21H19NO2
Afoxolaner chemical structure, C26H17ClF9N3O3, CAS 1093861-60-9
Afoxolaner
CAS 1093861-60-9C26H17ClF9N3O3
Afoxolaner impurity 29 chemical structure, C26H17BrF9N3O3, CAS 1093861-50-7
Afoxolaner impurity 29
CAS 1093861-50-7C26H17BrF9N3O3
Afoxolaner, (R)- chemical structure, C26H17ClF9N3O3, CAS 1096119-52-6
Afoxolaner, (R)-
CAS 1096119-52-6C26H17ClF9N3O3
Esafoxolaner chemical structure, C26H17ClF9N3O3, CAS 1096103-99-9
Esafoxolaner
CAS 1096103-99-9C26H17ClF9N3O3
Methyl 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-1-naphthalenecarboxylate chemical structure, C23H14ClF6NO3, CAS 1125812-60-3
Methyl 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-1-naphthalenecarboxylate
CAS 1125812-60-3C23H14ClF6NO3
4-(5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-1-naphthoic acid chemical structure, C21H11Cl2F4NO3, CAS 1308351-00-9
4-(5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-1-naphthoic acid
CAS 1308351-00-9C21H11Cl2F4NO3
4-[5-[3-Chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]naphthalene-1-carboxylic acid chemical structure, C22H12ClF6NO3, CAS 1308362-48-2
4-[5-[3-Chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]naphthalene-1-carboxylic acid
CAS 1308362-48-2C22H12ClF6NO3
Umifoxolaner chemical structure, C26H16ClF10N3O3, CAS 2021230-37-3
Umifoxolaner
CAS 2021230-37-3C26H16ClF10N3O3
Afoxolaner impurity 24 chemical structure, C23H16Cl2F3N3O3, CAS 1352722-19-0
Afoxolaner impurity 24
CAS 1352722-19-0C23H16Cl2F3N3O3
Nafoxametamide chemical structure, C24H16ClF6N3O3, CAS 2922827-79-8
Nafoxametamide
CAS 2922827-79-8C24H16ClF6N3O3
Nafoxametamide [ISO] chemical structure, C24H16ClF6N3O3
Nafoxametamide [ISO]
C24H16ClF6N3O3