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Murcko scaffold

Ring system with 4 rings and 20 atoms

24 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 20
Chemicals: 24
With full pages: 2

Scaffold SMILES

c1ccc(Oc2ncnc3sc4c(c23)CCCC4)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold c1ccc(Oc2ncnc3sc4c(c23)CCCC4)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 24 of 24 chemicals

4-(4-Isopropylphenoxy)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine chemical structure, C19H20N2OS, CAS 379242-83-8

4-(4-Isopropylphenoxy)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine

CAS 379242-83-8C₁₉H₂₀N₂OS

$3-(4-Methylphenoxy)-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6-tetraene chemical structure, C17H16N2OS, CAS 303227-16-9$

3-(4-Methylphenoxy)-8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6-tetraene

CAS 303227-16-9C₁₇H₁₆N₂OS

2-Methyl-4-(4-methylphenoxy)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine chemical structure, C18H18N2OS, CAS 304684-62-6

2-Methyl-4-(4-methylphenoxy)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine

CAS 304684-62-6C₁₈H₁₈N₂OS

1-(3-((5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)oxy)phenyl)ethan-1-one chemical structure, C18H16N2O2S, CAS 298207-77-9

1-(3-((5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)oxy)phenyl)ethan-1-one

CAS 298207-77-9C₁₈H₁₆N₂O₂S

4-(4-Chlorophenoxy)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine chemical structure, C16H13ClN2OS, CAS 300567-52-6

4-(4-Chlorophenoxy)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine

CAS 300567-52-6C₁₆H₁₃ClN₂OS

4-(5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yloxy)benzaldehyde chemical structure, C17H14N2O2S, CAS 304684-44-4

4-(5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yloxy)benzaldehyde

CAS 304684-44-4C₁₇H₁₄N₂O₂S

Methyl 4-[(2-methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)oxy]benzoate chemical structure, C19H18N2O3S, CAS 152998-71-5

Methyl 4-[(2-methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)oxy]benzoate

CAS 152998-71-5C₁₉H₁₈N₂O₃S

4-(2,4-Dichlorophenoxy)-2-methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine chemical structure, C17H14Cl2N2OS, CAS 307341-32-8

4-(2,4-Dichlorophenoxy)-2-methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine

CAS 307341-32-8C₁₇H₁₄Cl₂N₂OS

Ethyl 4-[(2-ethyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)oxy]benzoate chemical structure, C21H22N2O3S, CAS 379247-54-8

Ethyl 4-[(2-ethyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)oxy]benzoate

CAS 379247-54-8C₂₁H₂₂N₂O₃S

RefChem:381573 chemical structure, C16H13BrN2OS, CAS 5321-88-0

CAS 5321-88-0C₁₆H₁₃BrN₂OS

N-[3-[(2-Methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)oxy]phenyl]acetamide chemical structure, C19H19N3O2S, CAS 307511-73-5

N-[3-[(2-Methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)oxy]phenyl]acetamide

CAS 307511-73-5C₁₉H₁₉N₃O₂S

2-Methyl-4-[3-(trifluoromethyl)phenoxy]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine chemical structure, C18H15F3N2OS, CAS 452923-29-4

2-Methyl-4-[3-(trifluoromethyl)phenoxy]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine

CAS 452923-29-4C₁₈H₁₅F₃N₂OS

N-[3-(5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yloxy)phenyl]acetamide chemical structure, C18H17N3O2S, CAS 314261-55-7

N-[3-(5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yloxy)phenyl]acetamide

CAS 314261-55-7C₁₈H₁₇N₃O₂S

4-(4-tert-Butylphenoxy)-2-methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine chemical structure, C21H24N2OS, CAS 315684-91-4

4-(4-tert-Butylphenoxy)-2-methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine

CAS 315684-91-4C₂₁H₂₄N₂OS

3-Methoxy-4-(5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yloxy)benzaldehyde chemical structure, C18H16N2O3S, CAS 306956-52-5

3-Methoxy-4-(5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yloxy)benzaldehyde

CAS 306956-52-5C₁₈H₁₆N₂O₃S

Ethyl 3-[(2-methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)oxy]benzoate chemical structure, C20H20N2O3S, CAS 379242-22-5

Ethyl 3-[(2-methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)oxy]benzoate

CAS 379242-22-5C₂₀H₂₀N₂O₃S

4-(2,4-Dichlorophenoxy)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine chemical structure, C16H12Cl2N2OS, CAS 303793-63-7

4-(2,4-Dichlorophenoxy)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine

CAS 303793-63-7C₁₆H₁₂Cl₂N₂OS

3-Methoxy-4-[(2-methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)oxy]benzaldehyde chemical structure, C19H18N2O3S, CAS 379250-62-1

3-Methoxy-4-[(2-methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)oxy]benzaldehyde

CAS 379250-62-1C₁₉H₁₈N₂O₃S

4-(2-Methoxy-4-prop-2-enylphenoxy)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine chemical structure, C20H20N2O2S, CAS 315694-57-6

4-(2-Methoxy-4-prop-2-enylphenoxy)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine

CAS 315694-57-6C₂₀H₂₀N₂O₂S

3-(3-Chloro-4-fluorophenoxy)-8-thia-4,6-diazatricyclo[7.4.0.0,2,7]trideca-1(9),2,4,6-tetraene chemical structure, C16H12ClFN2OS, CAS 496025-15-1

3-(3-Chloro-4-fluorophenoxy)-8-thia-4,6-diazatricyclo[7.4.0.0,2,7]trideca-1(9),2,4,6-tetraene

CAS 496025-15-1C₁₆H₁₂ClFN₂OS

4-(4-Allyl-2-methoxyphenoxy)-7-methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine chemical structure, C21H22N2O2S, CAS 379244-51-6

4-(4-Allyl-2-methoxyphenoxy)-7-methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine

CAS 379244-51-6C₂₁H₂₂N₂O₂S

7-Methyl-4-[3-(trifluoromethyl)phenoxy]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine chemical structure, C18H15F3N2OS, CAS 670270-62-9

7-Methyl-4-[3-(trifluoromethyl)phenoxy]-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine

CAS 670270-62-9C₁₈H₁₅F₃N₂OS

4-(3,4-Dimethylphenoxy)-2,7-dimethyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine chemical structure, C20H22N2OS, CAS 379256-31-2

4-(3,4-Dimethylphenoxy)-2,7-dimethyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine

CAS 379256-31-2C₂₀H₂₂N₂OS

3-Methoxy-4-[(7-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)oxy]benzaldehyde chemical structure, C19H18N2O3S, CAS 561021-27-0

3-Methoxy-4-[(7-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-yl)oxy]benzaldehyde

CAS 561021-27-0C₁₉H₁₈N₂O₃S