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Murcko scaffold

Ring system with 3 rings and 20 atoms

10 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
10
With full pages
4
Scaffold SMILES

O=C(C=Cc1ccco1)CC1C(=O)Nc2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1ccco1)CC1C(=O)Nc2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 10 of 10 chemicals

1-Ethyl-3-[4-(2-furanyl)-2-oxo-3-buten-1-yl]-1,3-dihydro-3-hydroxy-2H-indol-2-one chemical structure, C18H17NO4, CAS 356081-53-3
1-Ethyl-3-[4-(2-furanyl)-2-oxo-3-buten-1-yl]-1,3-dihydro-3-hydroxy-2H-indol-2-one
CAS 356081-53-3C18H17NO4
5-Bromo-3-[(E)-4-(furan-2-yl)-2-oxobut-3-enyl]-3-hydroxy-1H-indol-2-one chemical structure, C16H12BrNO4, CAS 355428-86-3
5-Bromo-3-[(E)-4-(furan-2-yl)-2-oxobut-3-enyl]-3-hydroxy-1H-indol-2-one
CAS 355428-86-3C16H12BrNO4
(E)-3-(4-(Furan-2-yl)-2-oxobut-3-en-1-yl)-3-hydroxyindolin-2-one chemical structure, C16H13NO4, CAS 1609385-99-0
(E)-3-(4-(Furan-2-yl)-2-oxobut-3-en-1-yl)-3-hydroxyindolin-2-one
CAS 1609385-99-0C16H13NO4
Ethyl {3-[(3E)-4-(furan-2-yl)-2-oxobut-3-en-1-yl]-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-1-yl}acetate chemical structure, C20H19NO6, CAS 355434-73-0
Ethyl {3-[(3E)-4-(furan-2-yl)-2-oxobut-3-en-1-yl]-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-1-yl}acetate
CAS 355434-73-0C20H19NO6
3-[(E)-4-(Furan-2-yl)-2-oxobut-3-enyl]-3-hydroxy-1-methylindol-2-one chemical structure, C17H15NO4, CAS 355434-67-2
3-[(E)-4-(Furan-2-yl)-2-oxobut-3-enyl]-3-hydroxy-1-methylindol-2-one
CAS 355434-67-2C17H15NO4
5-Chloro-3-[(3E)-4-(furan-2-yl)-2-oxobut-3-en-1-yl]-3-hydroxy-1,3-dihydro-2H-indol-2-one chemical structure, C16H12ClNO4, CAS 355434-65-0
5-Chloro-3-[(3E)-4-(furan-2-yl)-2-oxobut-3-en-1-yl]-3-hydroxy-1,3-dihydro-2H-indol-2-one
CAS 355434-65-0C16H12ClNO4
5-Bromo-3-[(3E)-4-(furan-2-yl)-2-oxobut-3-en-1-yl]-3-hydroxy-1-methyl-1,3-dihydro-2H-indol-2-one chemical structure, C17H14BrNO4, CAS 356081-01-1
5-Bromo-3-[(3E)-4-(furan-2-yl)-2-oxobut-3-en-1-yl]-3-hydroxy-1-methyl-1,3-dihydro-2H-indol-2-one
CAS 356081-01-1C17H14BrNO4
3-[(E)-4-(Furan-2-yl)-2-oxobut-3-enyl]-3-hydroxy-1-prop-2-ynylindol-2-one chemical structure, C19H15NO4, CAS 356081-69-1
3-[(E)-4-(Furan-2-yl)-2-oxobut-3-enyl]-3-hydroxy-1-prop-2-ynylindol-2-one
CAS 356081-69-1C19H15NO4
2-[3-[(E)-4-(Furan-2-yl)-2-oxobut-3-enyl]-3-hydroxy-2-oxoindol-1-yl]acetamide chemical structure, C18H16N2O5, CAS 676614-97-4
2-[3-[(E)-4-(Furan-2-yl)-2-oxobut-3-enyl]-3-hydroxy-2-oxoindol-1-yl]acetamide
CAS 676614-97-4C18H16N2O5
3-[(E)-4-(Furan-2-yl)-2-oxobut-3-enyl]-3-hydroxy-1-propylindol-2-one chemical structure, C19H19NO4, CAS 688037-04-9
3-[(E)-4-(Furan-2-yl)-2-oxobut-3-enyl]-3-hydroxy-1-propylindol-2-one
CAS 688037-04-9C19H19NO4