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Murcko scaffold

Ring system with 4 rings and 19 atoms

18 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
19
Chemicals
18
With full pages
4
Scaffold SMILES

c1cc2c(Oc3ccc4[nH]ccc4c3)ncnn2c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1cc2c(Oc3ccc4[nH]ccc4c3)ncnn2c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-ol chemical structure, C16H13FN4O2, CAS 649735-41-1
4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-ol
CAS 649735-41-1C16H13FN4O2
Brivanib alaninate chemical structure, C22H24FN5O4, CAS 649735-63-7
Brivanib alaninate
CAS 649735-63-7C22H24FN5O4
Brivanib chemical structure, C19H19FN4O3, CAS 649735-46-6
Brivanib
CAS 649735-46-6C19H19FN4O3
1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methyl-6-pyrrolo[2,1-f][1,2,4]triazinyl]oxy]-2-propanol chemical structure, C19H19FN4O3, CAS 649735-47-7
1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methyl-6-pyrrolo[2,1-f][1,2,4]triazinyl]oxy]-2-propanol
CAS 649735-47-7C19H19FN4O3
(S)-1-(4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-ol chemical structure, C19H19FN4O3
(S)-1-(4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-ol
C19H19FN4O3
1-((4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo(2,1-f)(1,2,4)triazin-6-yl)oxy)-2-propanone chemical structure, C19H17FN4O3, CAS 649736-37-8
1-((4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo(2,1-f)(1,2,4)triazin-6-yl)oxy)-2-propanone
CAS 649736-37-8C19H17FN4O3
2-(4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)propan-2-ol chemical structure, C19H19FN4O2, CAS 649736-30-1
2-(4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)propan-2-ol
CAS 649736-30-1C19H19FN4O2
4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl pivalate chemical structure, C21H21FN4O3, CAS 952490-01-6
4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl pivalate
CAS 952490-01-6C21H21FN4O3
Ethyl 4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate chemical structure, C19H17FN4O3, CAS 649736-29-8
Ethyl 4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate
CAS 649736-29-8C19H17FN4O3
2-Propanol, 1-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo(2,1-F)(1,2,4)triazin-6-yl)oxy)-, 2-(hydrogen sulfate), (2R)- chemical structure, C19H19FN4O6S, CAS 1285403-71-5
2-Propanol, 1-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo(2,1-F)(1,2,4)triazin-6-yl)oxy)-, 2-(hydrogen sulfate), (2R)-
CAS 1285403-71-5C19H19FN4O6S
Propanoic acid, 2,2-dimethyl-, 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl-2-14C ester chemical structure, C21H21FN4O3, CAS 1316667-67-0
Propanoic acid, 2,2-dimethyl-, 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl-2-14C ester
CAS 1316667-67-0C21H21FN4O3
1H-Indole-2-methanol, 4-fluoro-5-((5-methyl-6-((2R)-2-(sulfooxy)propoxy)pyrrolo(2,1-F)(1,2,4)triazin-4-yl)oxy)- chemical structure, C19H19FN4O7S, CAS 1360432-39-8
1H-Indole-2-methanol, 4-fluoro-5-((5-methyl-6-((2R)-2-(sulfooxy)propoxy)pyrrolo(2,1-F)(1,2,4)triazin-4-yl)oxy)-
CAS 1360432-39-8C19H19FN4O7S
Pyrrolo(2,1-F)(1,2,4)triazin-6-ol, 4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methyl-, 6-(hydrogen sulfate) chemical structure, C16H13FN4O5S, CAS 1360432-05-8
Pyrrolo(2,1-F)(1,2,4)triazin-6-ol, 4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methyl-, 6-(hydrogen sulfate)
CAS 1360432-05-8C16H13FN4O5S
1H-Indole-2-carboxylic acid, 4-fluoro-5-((5-methyl-6-(sulfooxy)pyrrolo(2,1-F)(1,2,4)triazin-4-yl)oxy)- chemical structure, C16H11FN4O7S, CAS 1360431-54-4
1H-Indole-2-carboxylic acid, 4-fluoro-5-((5-methyl-6-(sulfooxy)pyrrolo(2,1-F)(1,2,4)triazin-4-yl)oxy)-
CAS 1360431-54-4C16H11FN4O7S
1H-Indole-2-carboxylic acid, 4-fluoro-5-((5-methyl-6-((2R)-2-(sulfooxy)propoxy)pyrrolo(2,1-F)(1,2,4)triazin-4-yl)oxy)- chemical structure, C19H17FN4O8S, CAS 1360431-91-9
1H-Indole-2-carboxylic acid, 4-fluoro-5-((5-methyl-6-((2R)-2-(sulfooxy)propoxy)pyrrolo(2,1-F)(1,2,4)triazin-4-yl)oxy)-
CAS 1360431-91-9C19H17FN4O8S
4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carbaldehyde chemical structure, C17H13FN4O2, CAS 1638768-25-8
4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carbaldehyde
CAS 1638768-25-8C17H13FN4O2
2-(5-Methyl-4-(2-methyl-1H-indol-5-yloxy)pyrrolo[1,2-F][1,2,4]triazin-6-yl)-2-propanol chemical structure, C19H20N4O2, CAS 2702312-98-7
2-(5-Methyl-4-(2-methyl-1H-indol-5-yloxy)pyrrolo[1,2-F][1,2,4]triazin-6-yl)-2-propanol
CAS 2702312-98-7C19H20N4O2
2-Propanol, 1-[[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl-2-14C]oxy]-, (2R)- chemical structure, C19H19FN4O3, CAS 1316667-69-2
2-Propanol, 1-[[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl-2-14C]oxy]-, (2R)-
CAS 1316667-69-2C19H19FN4O3