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Murcko scaffold

4-(Benzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane scaffold

36 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
36
With full pages
7
Scaffold SMILES

O=S(=O)(c1ccccc1)N1CCOC12CCNCC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4-(Benzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane page
Murcko scaffold O=S(=O)(c1ccccc1)N1CCOC12CCNCC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 36 of 36 chemicals

8-Butyryl-4-[(4-methylphenyl)sulfonyl]-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C18H26N2O4S, CAS 896377-81-4
8-Butyryl-4-[(4-methylphenyl)sulfonyl]-1-oxa-4,8-diazaspiro[4.5]decane
CAS 896377-81-4C18H26N2O4S
3,3-Dimethyl-1-[4-(4-methylbenzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl]butan-1-one chemical structure, C20H30N2O4S, CAS 896377-87-0
3,3-Dimethyl-1-[4-(4-methylbenzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl]butan-1-one
CAS 896377-87-0C20H30N2O4S
3-Methyl-1-[4-(4-methylbenzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl]butan-1-one chemical structure, C19H28N2O4S, CAS 896378-71-5
3-Methyl-1-[4-(4-methylbenzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl]butan-1-one
CAS 896378-71-5C19H28N2O4S
1-[4-(4-Methylbenzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl]propan-1-one chemical structure, C17H24N2O4S, CAS 896379-26-3
1-[4-(4-Methylbenzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl]propan-1-one
CAS 896379-26-3C17H24N2O4S
2-Ethoxy-1-(4-tosyl-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)ethanone chemical structure, C18H26N2O5S, CAS 896379-98-9
2-Ethoxy-1-(4-tosyl-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)ethanone
CAS 896379-98-9C18H26N2O5S
8-Acetyl-4-[(4-methoxyphenyl)sulfonyl]-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C16H22N2O5S, CAS 896359-63-0
8-Acetyl-4-[(4-methoxyphenyl)sulfonyl]-1-oxa-4,8-diazaspiro[4.5]decane
CAS 896359-63-0C16H22N2O5S
1-[4-(4-Methoxybenzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl]propan-1-one chemical structure, C17H24N2O5S, CAS 903342-52-9
1-[4-(4-Methoxybenzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl]propan-1-one
CAS 903342-52-9C17H24N2O5S
8-(Ethylsulfonyl)-4-tosyl-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C16H24N2O5S2, CAS 898408-15-6
8-(Ethylsulfonyl)-4-tosyl-1-oxa-4,8-diazaspiro[4.5]decane
CAS 898408-15-6C16H24N2O5S2
4-((4-Methoxyphenyl)sulfonyl)-8-(methylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C15H22N2O6S2, CAS 903306-61-6
4-((4-Methoxyphenyl)sulfonyl)-8-(methylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 903306-61-6C15H22N2O6S2
8-(Ethanesulfonyl)-4-(4-methoxybenzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C16H24N2O6S2, CAS 898408-22-5
8-(Ethanesulfonyl)-4-(4-methoxybenzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 898408-22-5C16H24N2O6S2
4-(Mesitylsulfonyl)-8-(methylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C17H26N2O5S2, CAS 903277-51-0
4-(Mesitylsulfonyl)-8-(methylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 903277-51-0C17H26N2O5S2
8-(Ethylsulfonyl)-4-(mesitylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C18H28N2O5S2, CAS 898425-12-2
8-(Ethylsulfonyl)-4-(mesitylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 898425-12-2C18H28N2O5S2
8-(Methylsulfonyl)-4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C14H20N2O5S2, CAS 906155-25-7
8-(Methylsulfonyl)-4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 906155-25-7C14H20N2O5S2
8-(Ethylsulfonyl)-4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C15H22N2O5S2, CAS 898408-36-1
8-(Ethylsulfonyl)-4-(phenylsulfonyl)-1-oxa-4,8-diazaspiro[4.5]decane
CAS 898408-36-1C15H22N2O5S2
1-(4-((4-Methoxyphenyl)sulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)-3,3-dimethylbutan-1-one chemical structure, C20H30N2O5S, CAS 903302-96-5
1-(4-((4-Methoxyphenyl)sulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)-3,3-dimethylbutan-1-one
CAS 903302-96-5C20H30N2O5S
N-Methyl-2-oxo-2-(4-tosyl-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)acetamide chemical structure, C17H23N3O5S, CAS 898425-42-8
N-Methyl-2-oxo-2-(4-tosyl-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)acetamide
CAS 898425-42-8C17H23N3O5S
1-[4-(4-Fluoro-3-methylbenzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl]butan-1-one chemical structure, C18H25FN2O4S, CAS 923185-38-0
1-[4-(4-Fluoro-3-methylbenzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl]butan-1-one
CAS 923185-38-0C18H25FN2O4S
3-Chloro-1-(4-((4-fluoro-3-methylphenyl)sulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)-2,2-dimethylpropan-1-one chemical structure, C19H26ClFN2O4S, CAS 923139-30-4
3-Chloro-1-(4-((4-fluoro-3-methylphenyl)sulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)-2,2-dimethylpropan-1-one
CAS 923139-30-4C19H26ClFN2O4S
N-Isopentyl-2-oxo-2-(4-tosyl-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)acetamide chemical structure, C21H31N3O5S, CAS 898425-39-3
N-Isopentyl-2-oxo-2-(4-tosyl-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)acetamide
CAS 898425-39-3C21H31N3O5S
N-Ethyl-2-oxo-2-(4-tosyl-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)acetamide chemical structure, C18H25N3O5S, CAS 898453-41-3
N-Ethyl-2-oxo-2-(4-tosyl-1-oxa-4,8-diazaspiro[4.5]decan-8-yl)acetamide
CAS 898453-41-3C18H25N3O5S
1-[4-(4-Fluoro-3-methylbenzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl]-3-methylbutan-1-one chemical structure, C19H27FN2O4S, CAS 946344-69-0
1-[4-(4-Fluoro-3-methylbenzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl]-3-methylbutan-1-one
CAS 946344-69-0C19H27FN2O4S
8-Acetyl-4-[(4-fluoro-3-methylphenyl)sulfonyl]-1-oxa-4,8-diazaspiro[4.5]decane chemical structure, C16H21FN2O4S, CAS 946262-25-5
8-Acetyl-4-[(4-fluoro-3-methylphenyl)sulfonyl]-1-oxa-4,8-diazaspiro[4.5]decane
CAS 946262-25-5C16H21FN2O4S
1-[4-(4-Fluoro-3-methylbenzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl]-2,2-dimethylpropan-1-one chemical structure, C19H27FN2O4S, CAS 946262-28-8
1-[4-(4-Fluoro-3-methylbenzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl]-2,2-dimethylpropan-1-one
CAS 946262-28-8C19H27FN2O4S
1-[4-(4-Fluoro-3-methylbenzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl]propan-1-one chemical structure, C17H23FN2O4S, CAS 946217-29-4
1-[4-(4-Fluoro-3-methylbenzenesulfonyl)-1-oxa-4,8-diazaspiro[4.5]decan-8-yl]propan-1-one
CAS 946217-29-4C17H23FN2O4S