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Murcko scaffold

Ring system with 4 rings and 29 atoms

22 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 29
Chemicals: 22
With full pages: 4

Scaffold SMILES

O=C(CSc1nnc(-c2ccccc2)[nH]1)Nc1ccc(Oc2ccccc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(CSc1nnc(-c2ccccc2)[nH]1)Nc1ccc(Oc2ccccc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 22 of 22 chemicals

2-{[4-Amino-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(4-phenoxyphenyl)acetamide chemical structure, C25H25N5O5S, CAS 710988-27-5

2-{[4-Amino-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(4-phenoxyphenyl)acetamide

CAS 710988-27-5C₂₅H₂₅N₅O₅S

2-[[5-(2-Methoxyphenyl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]-N-(4-phenoxyphenyl)acetamide chemical structure, C26H24N4O3S, CAS 825599-37-9

2-[[5-(2-Methoxyphenyl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]-N-(4-phenoxyphenyl)acetamide

CAS 825599-37-9C₂₆H₂₄N₄O₃S

2-[[4-Methyl-5-(4-nitrophenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(4-phenoxyphenyl)acetamide chemical structure, C23H19N5O4S, CAS 701228-32-2

2-[[4-Methyl-5-(4-nitrophenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(4-phenoxyphenyl)acetamide

CAS 701228-32-2C₂₃H₁₉N₅O₄S

2-{[4-Allyl-5-(2-bromophenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(4-phenoxyphenyl)acetamide chemical structure, C25H21BrN4O2S, CAS 573706-74-8

2-{[4-Allyl-5-(2-bromophenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(4-phenoxyphenyl)acetamide

CAS 573706-74-8C₂₅H₂₁BrN₄O₂S

2-[4-Amino-5-(2-fluorophenyl)(1,2,4-triazol-3-ylthio)]-N-(4-phenoxyphenyl)acet amide chemical structure, C22H18FN5O2S, CAS 573934-05-1

2-[4-Amino-5-(2-fluorophenyl)(1,2,4-triazol-3-ylthio)]-N-(4-phenoxyphenyl)acet amide

CAS 573934-05-1C₂₂H₁₈FN₅O₂S

2-((4-Amino-5-(4-CL-PH)-4H-1,2,4-triazol-3-yl)thio)-N-(4-phenoxyphenyl)acetamide chemical structure, C22H18ClN5O2S, CAS 573695-15-5

2-((4-Amino-5-(4-CL-PH)-4H-1,2,4-triazol-3-yl)thio)-N-(4-phenoxyphenyl)acetamide

CAS 573695-15-5C₂₂H₁₈ClN₅O₂S

2-[4-Amino-5-(3-methoxyphenyl)(1,2,4-triazol-3-ylthio)]-N-(4-phenoxyphenyl)ace tamide chemical structure, C23H21N5O3S, CAS 578748-73-9

2-[4-Amino-5-(3-methoxyphenyl)(1,2,4-triazol-3-ylthio)]-N-(4-phenoxyphenyl)ace tamide

CAS 578748-73-9C₂₃H₂₁N₅O₃S

2-((4-Amino-5-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(4-phenoxyphenyl)acetamide chemical structure, C22H19N5O2S, CAS 578754-22-0

2-((4-Amino-5-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(4-phenoxyphenyl)acetamide

CAS 578754-22-0C₂₂H₁₉N₅O₂S

2-{[4-Amino-5-(4-methylphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(4-phenoxyphenyl)acetamide chemical structure, C23H21N5O2S, CAS 577697-53-1

2-{[4-Amino-5-(4-methylphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(4-phenoxyphenyl)acetamide

CAS 577697-53-1C₂₃H₂₁N₅O₂S

2-{[4-Amino-5-(4-tert-butylphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(4-phenoxyphenyl)acetamide chemical structure, C26H27N5O2S, CAS 577699-95-7

2-{[4-Amino-5-(4-tert-butylphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(4-phenoxyphenyl)acetamide

CAS 577699-95-7C₂₆H₂₇N₅O₂S

2-{[4-Amino-5-(2-chlorophenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(4-phenoxyphenyl)acetamide chemical structure, C22H18ClN5O2S, CAS 586984-73-8

2-{[4-Amino-5-(2-chlorophenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(4-phenoxyphenyl)acetamide

CAS 586984-73-8C₂₂H₁₈ClN₅O₂S

2-({4-Amino-5-[3-(propan-2-yloxy)phenyl]-4H-1,2,4-triazol-3-yl}sulfanyl)-N-(4-phenoxyphenyl)acetamide chemical structure, C25H25N5O3S, CAS 579442-46-9

2-({4-Amino-5-[3-(propan-2-yloxy)phenyl]-4H-1,2,4-triazol-3-yl}sulfanyl)-N-(4-phenoxyphenyl)acetamide

CAS 579442-46-9C₂₅H₂₅N₅O₃S

2-[(4-Ethyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]-N-(4-phenoxyphenyl)acetamide chemical structure, C24H22N4O2S, CAS 692775-53-4

2-[(4-Ethyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]-N-(4-phenoxyphenyl)acetamide

CAS 692775-53-4C₂₄H₂₂N₄O₂S

2-{[4-Amino-5-(3,4-dimethoxyphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(4-phenoxyphenyl)acetamide chemical structure, C24H23N5O4S, CAS 842968-80-3

2-{[4-Amino-5-(3,4-dimethoxyphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(4-phenoxyphenyl)acetamide

CAS 842968-80-3C₂₄H₂₃N₅O₄S

2-{[4-Amino-5-(4-ethoxyphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(4-phenoxyphenyl)acetamide chemical structure, C24H23N5O3S, CAS 573706-41-9

2-{[4-Amino-5-(4-ethoxyphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(4-phenoxyphenyl)acetamide

CAS 573706-41-9C₂₄H₂₃N₅O₃S

2-{[4-Amino-5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(4-phenoxyphenyl)acetamide chemical structure, C23H21N5O3S, CAS 840498-03-5

2-{[4-Amino-5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(4-phenoxyphenyl)acetamide

CAS 840498-03-5C₂₃H₂₁N₅O₃S

2-((4-Amino-5-(3-CL-PH)-4H-1,2,4-triazol-3-yl)thio)-N-(4-phenoxyphenyl)acetamide chemical structure, C22H18ClN5O2S, CAS 763106-44-1

2-((4-Amino-5-(3-CL-PH)-4H-1,2,4-triazol-3-yl)thio)-N-(4-phenoxyphenyl)acetamide

CAS 763106-44-1C₂₂H₁₈ClN₅O₂S

2-{[4-Amino-5-(2,4-dichlorophenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(4-phenoxyphenyl)acetamide chemical structure, C22H17Cl2N5O2S, CAS 578752-40-6

2-{[4-Amino-5-(2,4-dichlorophenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(4-phenoxyphenyl)acetamide

CAS 578752-40-6C₂₂H₁₇Cl₂N₅O₂S

2-[[4-Methyl-5-(4-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(4-phenoxyphenyl)acetamide chemical structure, C24H22N4O2S, CAS 838587-65-8

2-[[4-Methyl-5-(4-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(4-phenoxyphenyl)acetamide

CAS 838587-65-8C₂₄H₂₂N₄O₂S

N-(4-Phenoxyphenyl)-2-((3-(m-tolyl)-1H-1,2,4-triazol-5-yl)thio)acetamide chemical structure, C23H20N4O2S, CAS 332158-99-3

N-(4-Phenoxyphenyl)-2-((3-(m-tolyl)-1H-1,2,4-triazol-5-yl)thio)acetamide

CAS 332158-99-3C₂₃H₂₀N₄O₂S

2-{[4-Amino-5-(2-methylphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(4-phenoxyphenyl)acetamide chemical structure, C23H21N5O2S, CAS 578746-49-3

2-{[4-Amino-5-(2-methylphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(4-phenoxyphenyl)acetamide

CAS 578746-49-3C₂₃H₂₁N₅O₂S

2-{[4-Amino-5-(3-methylphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(4-phenoxyphenyl)acetamide chemical structure, C23H21N5O2S, CAS 880802-52-8

2-{[4-Amino-5-(3-methylphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(4-phenoxyphenyl)acetamide

CAS 880802-52-8C₂₃H₂₁N₅O₂S