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Murcko scaffold

Adamantan-1-yl-(4-phenyl-piperazin-1-yl)-methanone scaffold

19 chemicals on CompoundList share this ring system.

Rings
6
Scaffold atoms
24
Chemicals
19
With full pages
4
Scaffold SMILES

O=C(N1CCN(c2ccccc2)CC1)C12CC3CC(CC(C3)C1)C2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Adamantan-1-yl-(4-phenyl-piperazin-1-yl)-methanone page
Murcko scaffold O=C(N1CCN(c2ccccc2)CC1)C12CC3CC(CC(C3)C1)C2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 19 of 19 chemicals

1-Adamantyl-[4-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]piperazin-1-yl]methanone chemical structure, C22H23F7N2O, CAS 312617-35-9
1-Adamantyl-[4-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]piperazin-1-yl]methanone
CAS 312617-35-9C22H23F7N2O
Adamantan-1-yl-(4-phenyl-piperazin-1-yl)-methanone chemical structure, C21H28N2O, CAS 313962-96-8
Adamantan-1-yl-(4-phenyl-piperazin-1-yl)-methanone
CAS 313962-96-8C21H28N2O
1-Adamantyl-[4-(4-nitrophenyl)piperazin-1-yl]methanone chemical structure, C21H27N3O3, CAS 332037-27-1
1-Adamantyl-[4-(4-nitrophenyl)piperazin-1-yl]methanone
CAS 332037-27-1C21H27N3O3
Adamantanyl 4-(4-fluorophenyl)piperazinyl ketone chemical structure, C21H27FN2O, CAS 327094-11-1
Adamantanyl 4-(4-fluorophenyl)piperazinyl ketone
CAS 327094-11-1C21H27FN2O
1-(1-Adamantylcarbonyl)-4-(2-fluorophenyl)piperazine chemical structure, C21H27FN2O, CAS 496054-77-4
1-(1-Adamantylcarbonyl)-4-(2-fluorophenyl)piperazine
CAS 496054-77-4C21H27FN2O
Adamantanyl 4-(3,4-dichlorophenyl)piperazinyl ketone chemical structure, C21H26Cl2N2O, CAS 667892-06-0
Adamantanyl 4-(3,4-dichlorophenyl)piperazinyl ketone
CAS 667892-06-0C21H26Cl2N2O
1-Adamantyl-[4-(3,4-dimethylphenyl)piperazin-1-yl]methanone chemical structure, C23H32N2O, CAS 667892-04-8
1-Adamantyl-[4-(3,4-dimethylphenyl)piperazin-1-yl]methanone
CAS 667892-04-8C23H32N2O
1-(1-Adamantylcarbonyl)-4-(2,5-dichlorophenyl)piperazine chemical structure, C21H26Cl2N2O, CAS 667893-18-7
1-(1-Adamantylcarbonyl)-4-(2,5-dichlorophenyl)piperazine
CAS 667893-18-7C21H26Cl2N2O
1-Adamantyl-[4-(2-chlorophenyl)piperazin-1-yl]methanone chemical structure, C21H27ClN2O, CAS 405077-28-3
1-Adamantyl-[4-(2-chlorophenyl)piperazin-1-yl]methanone
CAS 405077-28-3C21H27ClN2O
1-(Adamantane-1-carbonyl)-4-(4-ethylphenyl)piperazine chemical structure, C23H32N2O, CAS 708225-15-4
1-(Adamantane-1-carbonyl)-4-(4-ethylphenyl)piperazine
CAS 708225-15-4C23H32N2O
Adamantanyl 4-(5-chloro-2-methylphenyl)piperazinyl ketone chemical structure, C22H29ClN2O, CAS 496054-76-3
Adamantanyl 4-(5-chloro-2-methylphenyl)piperazinyl ketone
CAS 496054-76-3C22H29ClN2O
[4-(4-Methoxyphenyl)piperazin-1-yl]-(3,5,7-trimethyl-1-adamantyl)methanone chemical structure, C25H36N2O2, CAS 717864-45-4
[4-(4-Methoxyphenyl)piperazin-1-yl]-(3,5,7-trimethyl-1-adamantyl)methanone
CAS 717864-45-4C25H36N2O2
Adamantanyl 4-(2,6-dimethylphenyl)piperazinyl ketone chemical structure, C23H32N2O, CAS 405077-18-1
Adamantanyl 4-(2,6-dimethylphenyl)piperazinyl ketone
CAS 405077-18-1C23H32N2O
(Adamantan-1-yl)[4-(2-ethoxyphenyl)piperazin-1-yl]methanone chemical structure, C23H32N2O2, CAS 405077-31-8
(Adamantan-1-yl)[4-(2-ethoxyphenyl)piperazin-1-yl]methanone
CAS 405077-31-8C23H32N2O2
Adamantanyl 4-(3-chlorophenyl)piperazinyl ketone chemical structure, C21H27ClN2O, CAS 551901-86-1
Adamantanyl 4-(3-chlorophenyl)piperazinyl ketone
CAS 551901-86-1C21H27ClN2O
1-(1-Adamantylcarbonyl)-4-(2,4-dimethylphenyl)piperazine chemical structure, C23H32N2O, CAS 667893-17-6
1-(1-Adamantylcarbonyl)-4-(2,4-dimethylphenyl)piperazine
CAS 667893-17-6C23H32N2O
1-Adamantyl-[4-(4-chlorophenyl)piperazin-1-yl]methanone chemical structure, C21H27ClN2O, CAS 405076-93-9
1-Adamantyl-[4-(4-chlorophenyl)piperazin-1-yl]methanone
CAS 405076-93-9C21H27ClN2O
Adamantanyl 4-(3-chloro-4-methylphenyl)piperazinyl ketone chemical structure, C22H29ClN2O, CAS 663938-67-8
Adamantanyl 4-(3-chloro-4-methylphenyl)piperazinyl ketone
CAS 663938-67-8C22H29ClN2O
FXR agonist 4 chemical structure, C21H28ClN3O, CAS 3025841-47-5
FXR agonist 4
CAS 3025841-47-5C21H28ClN3O