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Murcko scaffold

Ring system with 4 rings and 23 atoms

11 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 23
Chemicals: 11
With full pages: 3

Scaffold SMILES

O=C1OCC2=C1C(c1ccccc1)CC(=O)N2c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1OCC2=C1C(c1ccccc1)CC(=O)N2c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 11 of 11 chemicals

4-(4-Methylsulfanylphenyl)-1-[3-(trifluoromethyl)phenyl]-4,7-dihydro-3H-furo[3,4-b]pyridine-2,5-dione chemical structure, C21H16F3NO3S, CAS 727664-50-8

4-(4-Methylsulfanylphenyl)-1-[3-(trifluoromethyl)phenyl]-4,7-dihydro-3H-furo[3,4-b]pyridine-2,5-dione

CAS 727664-50-8C₂₁H₁₆F₃NO₃S

1-(3-Fluorophenyl)-4-phenyl-4,7-dihydrofuro[3,4-b]pyridine-2,5(1H,3H)-dione chemical structure, C19H14FNO3, CAS 727661-11-2

1-(3-Fluorophenyl)-4-phenyl-4,7-dihydrofuro[3,4-b]pyridine-2,5(1H,3H)-dione

CAS 727661-11-2C₁₉H₁₄FNO₃

1-Phenyl-4-(3,4,5-trimethoxyphenyl)-4,7-dihydro-3H-furo[3,4-b]pyridine-2,5-dione chemical structure, C22H21NO6, CAS 697245-76-4

1-Phenyl-4-(3,4,5-trimethoxyphenyl)-4,7-dihydro-3H-furo[3,4-b]pyridine-2,5-dione

CAS 697245-76-4C₂₂H₂₁NO₆

4-(4-Hydroxy-3-methoxyphenyl)-1-phenyl-4,7-dihydro-3H-furo[3,4-b]pyridine-2,5-dione chemical structure, C20H17NO5, CAS 878435-06-4

4-(4-Hydroxy-3-methoxyphenyl)-1-phenyl-4,7-dihydro-3H-furo[3,4-b]pyridine-2,5-dione

CAS 878435-06-4C₂₀H₁₇NO₅

1-(3-Fluorophenyl)-4-(4-hydroxy-3-methoxyphenyl)-4,7-dihydro-3H-furo[3,4-b]pyridine-2,5-dione chemical structure, C20H16FNO5, CAS 878435-10-0

1-(3-Fluorophenyl)-4-(4-hydroxy-3-methoxyphenyl)-4,7-dihydro-3H-furo[3,4-b]pyridine-2,5-dione

CAS 878435-10-0C₂₀H₁₆FNO₅

4-(3-Methoxyphenyl)-1-(3-methylphenyl)-4,7-dihydro-3H-furo[3,4-b]pyridine-2,5-dione chemical structure, C21H19NO4, CAS 900890-25-7

4-(3-Methoxyphenyl)-1-(3-methylphenyl)-4,7-dihydro-3H-furo[3,4-b]pyridine-2,5-dione

CAS 900890-25-7C₂₁H₁₉NO₄

1-(4-Fluorophenyl)-4-(3,4,5-trimethoxyphenyl)-4,7-dihydro-3H-furo[3,4-b]pyridine-2,5-dione chemical structure, C22H20FNO6, CAS 697243-64-4

1-(4-Fluorophenyl)-4-(3,4,5-trimethoxyphenyl)-4,7-dihydro-3H-furo[3,4-b]pyridine-2,5-dione

CAS 697243-64-4C₂₂H₂₀FNO₆

4-(4-Methoxyphenyl)-1-(4-methylphenyl)-4,7-dihydro-3H-furo[3,4-b]pyridine-2,5-dione chemical structure, C21H19NO4, CAS 900900-38-1

4-(4-Methoxyphenyl)-1-(4-methylphenyl)-4,7-dihydro-3H-furo[3,4-b]pyridine-2,5-dione

CAS 900900-38-1C₂₁H₁₉NO₄

4-(2,3-Dimethoxyphenyl)-1-(3-fluorophenyl)-4,7-dihydro-3H-furo[3,4-b]pyridine-2,5-dione chemical structure, C21H18FNO5, CAS 727660-58-4

4-(2,3-Dimethoxyphenyl)-1-(3-fluorophenyl)-4,7-dihydro-3H-furo[3,4-b]pyridine-2,5-dione

CAS 727660-58-4C₂₁H₁₈FNO₅

4-(2,3-Dimethoxyphenyl)-1-(4-fluorophenyl)-4,7-dihydro-3H-furo[3,4-b]pyridine-2,5-dione chemical structure, C21H18FNO5, CAS 697245-77-5

4-(2,3-Dimethoxyphenyl)-1-(4-fluorophenyl)-4,7-dihydro-3H-furo[3,4-b]pyridine-2,5-dione

CAS 697245-77-5C₂₁H₁₈FNO₅

1-(3-Fluorophenyl)-4-(3-methoxyphenyl)-4,7-dihydrofuro[3,4-b]pyridine-2,5(1H,3H)-dione chemical structure, C20H16FNO4, CAS 727659-90-7

1-(3-Fluorophenyl)-4-(3-methoxyphenyl)-4,7-dihydrofuro[3,4-b]pyridine-2,5(1H,3H)-dione

CAS 727659-90-7C₂₀H₁₆FNO₄