Murcko scaffold
Ring system with 5 rings and 27 atoms
18 chemicals on CompoundList share this ring system.
- Rings
- 5
- Scaffold atoms
- 27
- Chemicals
- 18
- With full pages
- 3
Scaffold SMILES
O=C1c2[nH]nc(-c3ccccc3)c2C(c2ccccc2)N1c1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
![Murcko scaffold O=C1c2[nH]nc(-c3ccccc3)c2C(c2ccccc2)N1c1ccccc1](/scaffold/TZCIQTXJNXQVIJ-UHFFFAOYSA-N/structure.svg)
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 18 of 18 chemicals
![4-(2-Nitrophenyl)-3,5-diphenyl-1,4-dihydropyrrolo[3,4-c]pyrazol-6-one chemical structure, C23H16N4O3, CAS 337922-47-1](/s/WQYDPNUSTYWUQI-UHFFFAOYSA-N.svg)
4-(2-Nitrophenyl)-3,5-diphenyl-1,4-dihydropyrrolo[3,4-c]pyrazol-6-one
CAS 337922-47-1C23H16N4O3
![4-(2-Fluorophenyl)-3-(4-methoxyphenyl)-5-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one chemical structure, C24H18FN3O2, CAS 6166-77-4](/s/HYBQILQPKIVEHZ-UHFFFAOYSA-N.svg)
4-(2-Fluorophenyl)-3-(4-methoxyphenyl)-5-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one
CAS 6166-77-4C24H18FN3O2
![3-(4-Methoxyphenyl)-4-(3-nitrophenyl)-5-phenyl-1,4-dihydropyrrolo[3,4-c]pyrazol-6-one chemical structure, C24H18N4O4, CAS 425415-27-6](/s/NWTBFVZUIHEJGA-UHFFFAOYSA-N.svg)
3-(4-Methoxyphenyl)-4-(3-nitrophenyl)-5-phenyl-1,4-dihydropyrrolo[3,4-c]pyrazol-6-one
CAS 425415-27-6C24H18N4O4
![3-(4-Chlorophenyl)-4-(2-nitrophenyl)-5-phenyl-1,4-dihydropyrrolo[3,4-c]pyrazol-6-one chemical structure, C23H15ClN4O3, CAS 425425-92-9](/s/PAYKQYOPUXKCJM-UHFFFAOYSA-N.svg)
3-(4-Chlorophenyl)-4-(2-nitrophenyl)-5-phenyl-1,4-dihydropyrrolo[3,4-c]pyrazol-6-one
CAS 425425-92-9C23H15ClN4O3
![4-(3,4-Dimethoxyphenyl)-3-(4-methoxyphenyl)-5-phenyl-1,4-dihydropyrrolo[3,4-c]pyrazol-6-one chemical structure, C26H23N3O4, CAS 425612-15-3](/s/VJDDYLRGUUCFEM-UHFFFAOYSA-N.svg)
4-(3,4-Dimethoxyphenyl)-3-(4-methoxyphenyl)-5-phenyl-1,4-dihydropyrrolo[3,4-c]pyrazol-6-one
CAS 425612-15-3C26H23N3O4
![3-(4-Methoxyphenyl)-4-(2-nitrophenyl)-5-phenyl-1,4-dihydropyrrolo[3,4-c]pyrazol-6-one chemical structure, C24H18N4O4, CAS 425614-14-8](/s/UDCANTFWWZYEOR-UHFFFAOYSA-N.svg)
3-(4-Methoxyphenyl)-4-(2-nitrophenyl)-5-phenyl-1,4-dihydropyrrolo[3,4-c]pyrazol-6-one
CAS 425614-14-8C24H18N4O4
![3-(4-Methoxyphenyl)-4-(4-nitrophenyl)-5-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one chemical structure, C24H18N4O4, CAS 425619-27-8](/s/BQDKLYYMXAFZME-UHFFFAOYSA-N.svg)
3-(4-Methoxyphenyl)-4-(4-nitrophenyl)-5-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one
CAS 425619-27-8C24H18N4O4
![4-(2,5-Dimethoxyphenyl)-3-(4-fluorophenyl)-5-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one chemical structure, C25H20FN3O3, CAS 500197-97-7](/s/JHDSSZONUOSKPT-UHFFFAOYSA-N.svg)
4-(2,5-Dimethoxyphenyl)-3-(4-fluorophenyl)-5-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one
CAS 500197-97-7C25H20FN3O3
![4-(2,4-Dichlorophenyl)-3-(4-fluorophenyl)-5-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one chemical structure, C23H14Cl2FN3O, CAS 488861-40-1](/s/YHTKLMXDKSCDNA-UHFFFAOYSA-N.svg)
4-(2,4-Dichlorophenyl)-3-(4-fluorophenyl)-5-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one
CAS 488861-40-1C23H14Cl2FN3O
CBMicro_012826
CAS 5970-98-9C24H17FN4O3
![5-(4-Fluorophenyl)-3-(4-methylphenyl)-4-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one chemical structure, C24H18FN3O, CAS 370870-57-8](/s/QRLXAPQVRKIHEC-UHFFFAOYSA-N.svg)
5-(4-Fluorophenyl)-3-(4-methylphenyl)-4-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one
CAS 370870-57-8C24H18FN3O
![4-(3-Fluorophenyl)-3-(4-methylphenyl)-5-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one chemical structure, C24H18FN3O, CAS 404911-50-8](/s/URHBKQBUDUPOEQ-UHFFFAOYSA-N.svg)
4-(3-Fluorophenyl)-3-(4-methylphenyl)-5-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one
CAS 404911-50-8C24H18FN3O
![5-(4-Fluorophenyl)-4-(4-hydroxyphenyl)-3-(4-methylphenyl)-1,4-dihydropyrrolo[3,4-c]pyrazol-6-one chemical structure, C24H18FN3O2, CAS 423750-10-1](/s/PZLCUCBAPYNLII-UHFFFAOYSA-N.svg)
5-(4-Fluorophenyl)-4-(4-hydroxyphenyl)-3-(4-methylphenyl)-1,4-dihydropyrrolo[3,4-c]pyrazol-6-one
CAS 423750-10-1C24H18FN3O2
4,5-Dihydro-4-(4-(1-methylethyl)phenyl)-3,5-diphenylpyrrolo(3,4-c)pyrazol-6(1H)-one
CAS 352324-49-3C26H23N3O
![5-(4-Fluorophenyl)-4-(4-hydroxy-3-methoxyphenyl)-3-(4-methylphenyl)-1,4-dihydropyrrolo[3,4-c]pyrazol-6-one chemical structure, C25H20FN3O3, CAS 423749-62-6](/s/QZINTYDNAUQPGJ-UHFFFAOYSA-N.svg)
5-(4-Fluorophenyl)-4-(4-hydroxy-3-methoxyphenyl)-3-(4-methylphenyl)-1,4-dihydropyrrolo[3,4-c]pyrazol-6-one
CAS 423749-62-6C25H20FN3O3
![5-(4-Bromophenyl)-4-(3,4-dimethoxyphenyl)-3-(4-ethoxyphenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one chemical structure, C27H24BrN3O4, CAS 834903-45-6](/s/VMZKVRJBVGZVQB-UHFFFAOYSA-N.svg)
5-(4-Bromophenyl)-4-(3,4-dimethoxyphenyl)-3-(4-ethoxyphenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one
CAS 834903-45-6C27H24BrN3O4
![5-(4-Chlorophenyl)-4-(3-fluorophenyl)-3-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one chemical structure, C23H15ClFN3O, CAS 404911-58-6](/s/HAUOPYAKJVGAHH-UHFFFAOYSA-N.svg)
5-(4-Chlorophenyl)-4-(3-fluorophenyl)-3-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one
CAS 404911-58-6C23H15ClFN3O
4-(4-(3-Hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid
CAS 834903-43-4C25H19N3O4