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Murcko scaffold

Ring system with 4 rings and 23 atoms

7 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
7
With full pages
2
Scaffold SMILES

O=C1Nc2ccccc2C1=C1SC(=S)N(Cc2ccco2)C1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1Nc2ccccc2C1=C1SC(=S)N(Cc2ccco2)C1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 7 of 7 chemicals

(5Z)-5-(5-Bromo-2-oxo-1-prop-2-enylindol-3-ylidene)-3-(furan-2-ylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C19H13BrN2O3S2, CAS 381694-90-2
(5Z)-5-(5-Bromo-2-oxo-1-prop-2-enylindol-3-ylidene)-3-(furan-2-ylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 381694-90-2C19H13BrN2O3S2
(3Z)-3-[3-(Furan-2-ylmethyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1-(prop-2-en-1-yl)-1,3-dihydro-2H-indol-2-one chemical structure, C19H14N2O3S2, CAS 373619-15-9
(3Z)-3-[3-(Furan-2-ylmethyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1-(prop-2-en-1-yl)-1,3-dihydro-2H-indol-2-one
CAS 373619-15-9C19H14N2O3S2
(3Z)-1-Ethyl-3-[3-(furan-2-ylmethyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one chemical structure, C18H14N2O3S2, CAS 324544-27-6
(3Z)-1-Ethyl-3-[3-(furan-2-ylmethyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one
CAS 324544-27-6C18H14N2O3S2
3-(2-Furylmethyl)-5-(1-methyl-2-oxo-1,2-dihydro-3H-indol-3-yliden)-2-thioxo-1,3-thiazolan-4-one chemical structure, C17H12N2O3S2, CAS 324543-81-9
3-(2-Furylmethyl)-5-(1-methyl-2-oxo-1,2-dihydro-3H-indol-3-yliden)-2-thioxo-1,3-thiazolan-4-one
CAS 324543-81-9C17H12N2O3S2
5-(5-Bromo-1-methyl-2-oxo-1,2-dihydro-3H-indol-3-yliden)-3-(2-furylmethyl)-2-thioxo-1,3-thiazolan-4-one chemical structure, C17H11BrN2O3S2, CAS 374100-58-0
5-(5-Bromo-1-methyl-2-oxo-1,2-dihydro-3H-indol-3-yliden)-3-(2-furylmethyl)-2-thioxo-1,3-thiazolan-4-one
CAS 374100-58-0C17H11BrN2O3S2
(3Z)-5-Bromo-1-ethyl-3-(3-(2-furylmethyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one chemical structure, C18H13BrN2O3S2, CAS 617697-84-4
(3Z)-5-Bromo-1-ethyl-3-(3-(2-furylmethyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one
CAS 617697-84-4C18H13BrN2O3S2
(3Z)-5-Bromo-1-butyl-3-(3-(2-furylmethyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one chemical structure, C20H17BrN2O3S2, CAS 618077-73-9
(3Z)-5-Bromo-1-butyl-3-(3-(2-furylmethyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one
CAS 618077-73-9C20H17BrN2O3S2