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Murcko scaffold

Ring system with 4 rings and 23 atoms

33 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
33
With full pages
2
Scaffold SMILES

O=C(Nc1nonc1-c1ccccc1)c1cc2ccccc2o1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1nonc1-c1ccccc1)c1cc2ccccc2o1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 33 of 33 chemicals

5-Fluoro-3-methyl-N-(4-phenyl-1,2,5-oxadiazol-3-yl)-1-benzofuran-2-carboxamide chemical structure, C18H12FN3O3, CAS 866236-97-7
5-Fluoro-3-methyl-N-(4-phenyl-1,2,5-oxadiazol-3-yl)-1-benzofuran-2-carboxamide
CAS 866236-97-7C18H12FN3O3
5-Chloro-3-methyl-N-(4-phenyl-1,2,5-oxadiazol-3-yl)-1-benzofuran-2-carboxamide chemical structure, C18H12ClN3O3, CAS 866236-96-6
5-Chloro-3-methyl-N-(4-phenyl-1,2,5-oxadiazol-3-yl)-1-benzofuran-2-carboxamide
CAS 866236-96-6C18H12ClN3O3
6-Bromo-3-methyl-N-(4-phenyl-1,2,5-oxadiazol-3-yl)-1-benzofuran-2-carboxamide chemical structure, C18H12BrN3O3, CAS 898599-82-1
6-Bromo-3-methyl-N-(4-phenyl-1,2,5-oxadiazol-3-yl)-1-benzofuran-2-carboxamide
CAS 898599-82-1C18H12BrN3O3
N-[4-(4-Methoxyphenyl)-1,2,5-oxadiazol-3-yl]-3-methyl-1-benzofuran-2-carboxamide chemical structure, C19H15N3O4, CAS 879765-49-8
N-[4-(4-Methoxyphenyl)-1,2,5-oxadiazol-3-yl]-3-methyl-1-benzofuran-2-carboxamide
CAS 879765-49-8C19H15N3O4
N-[4-(3,4-Dimethoxyphenyl)-1,2,5-oxadiazol-3-yl]-3,5-dimethyl-1-benzofuran-2-carboxamide chemical structure, C21H19N3O5, CAS 898635-45-5
N-[4-(3,4-Dimethoxyphenyl)-1,2,5-oxadiazol-3-yl]-3,5-dimethyl-1-benzofuran-2-carboxamide
CAS 898635-45-5C21H19N3O5
3-Methyl-N-(4-phenyl-1,2,5-oxadiazol-3-yl)-1-benzofuran-2-carboxamide chemical structure, C18H13N3O3, CAS 879576-48-4
3-Methyl-N-(4-phenyl-1,2,5-oxadiazol-3-yl)-1-benzofuran-2-carboxamide
CAS 879576-48-4C18H13N3O3
N-[4-(3,4-Dimethoxyphenyl)-1,2,5-oxadiazol-3-yl]-3-methyl-1-benzofuran-2-carboxamide chemical structure, C20H17N3O5, CAS 898606-82-1
N-[4-(3,4-Dimethoxyphenyl)-1,2,5-oxadiazol-3-yl]-3-methyl-1-benzofuran-2-carboxamide
CAS 898606-82-1C20H17N3O5
5-Fluoro-N-[4-(4-fluorophenyl)-1,2,5-oxadiazol-3-yl]-3-methyl-1-benzofuran-2-carboxamide chemical structure, C18H11F2N3O3, CAS 898485-51-3
5-Fluoro-N-[4-(4-fluorophenyl)-1,2,5-oxadiazol-3-yl]-3-methyl-1-benzofuran-2-carboxamide
CAS 898485-51-3C18H11F2N3O3
5-Fluoro-N-[4-(4-methoxyphenyl)-1,2,5-oxadiazol-3-yl]-3-methyl-1-benzofuran-2-carboxamide chemical structure, C19H14FN3O4, CAS 898485-15-9
5-Fluoro-N-[4-(4-methoxyphenyl)-1,2,5-oxadiazol-3-yl]-3-methyl-1-benzofuran-2-carboxamide
CAS 898485-15-9C19H14FN3O4
5-Ethyl-N-[4-(4-fluorophenyl)-1,2,5-oxadiazol-3-yl]-3-methyl-1-benzofuran-2-carboxamide chemical structure, C20H16FN3O3, CAS 898618-48-9
5-Ethyl-N-[4-(4-fluorophenyl)-1,2,5-oxadiazol-3-yl]-3-methyl-1-benzofuran-2-carboxamide
CAS 898618-48-9C20H16FN3O3
5-Chloro-N-[4-(4-fluorophenyl)-1,2,5-oxadiazol-3-yl]-3,6-dimethyl-1-benzofuran-2-carboxamide chemical structure, C19H13ClFN3O3, CAS 898618-47-8
5-Chloro-N-[4-(4-fluorophenyl)-1,2,5-oxadiazol-3-yl]-3,6-dimethyl-1-benzofuran-2-carboxamide
CAS 898618-47-8C19H13ClFN3O3
3,6-Dimethyl-N-(4-phenyl-1,2,5-oxadiazol-3-yl)-1-benzofuran-2-carboxamide chemical structure, C19H15N3O3, CAS 898485-09-1
3,6-Dimethyl-N-(4-phenyl-1,2,5-oxadiazol-3-yl)-1-benzofuran-2-carboxamide
CAS 898485-09-1C19H15N3O3
N-[4-(3,4-Dimethoxyphenyl)-1,2,5-oxadiazol-3-yl]-3,6-dimethyl-1-benzofuran-2-carboxamide chemical structure, C21H19N3O5, CAS 898485-39-7
N-[4-(3,4-Dimethoxyphenyl)-1,2,5-oxadiazol-3-yl]-3,6-dimethyl-1-benzofuran-2-carboxamide
CAS 898485-39-7C21H19N3O5
N-[4-(4-Fluorophenyl)-1,2,5-oxadiazol-3-yl]-3-methyl-1-benzofuran-2-carboxamide chemical structure, C18H12FN3O3, CAS 898618-50-3
N-[4-(4-Fluorophenyl)-1,2,5-oxadiazol-3-yl]-3-methyl-1-benzofuran-2-carboxamide
CAS 898618-50-3C18H12FN3O3
N-[4-(3,4-Diethoxyphenyl)-1,2,5-oxadiazol-3-yl]-3,6-dimethyl-1-benzofuran-2-carboxamide chemical structure, C23H23N3O5, CAS 880408-09-3
N-[4-(3,4-Diethoxyphenyl)-1,2,5-oxadiazol-3-yl]-3,6-dimethyl-1-benzofuran-2-carboxamide
CAS 880408-09-3C23H23N3O5
N-[4-(3,4-Diethoxyphenyl)-1,2,5-oxadiazol-3-yl]-3,5-dimethyl-1-benzofuran-2-carboxamide chemical structure, C23H23N3O5, CAS 880396-77-0
N-[4-(3,4-Diethoxyphenyl)-1,2,5-oxadiazol-3-yl]-3,5-dimethyl-1-benzofuran-2-carboxamide
CAS 880396-77-0C23H23N3O5
5-Chloro-N-[4-(4-ethoxyphenyl)-1,2,5-oxadiazol-3-yl]-3-methyl-1-benzofuran-2-carboxamide chemical structure, C20H16ClN3O4, CAS 874400-03-0
5-Chloro-N-[4-(4-ethoxyphenyl)-1,2,5-oxadiazol-3-yl]-3-methyl-1-benzofuran-2-carboxamide
CAS 874400-03-0C20H16ClN3O4
5-Bromo-N-[4-(4-ethoxyphenyl)-1,2,5-oxadiazol-3-yl]-3-methyl-1-benzofuran-2-carboxamide chemical structure, C20H16BrN3O4, CAS 874400-16-5
5-Bromo-N-[4-(4-ethoxyphenyl)-1,2,5-oxadiazol-3-yl]-3-methyl-1-benzofuran-2-carboxamide
CAS 874400-16-5C20H16BrN3O4
N-[4-(4-Ethoxyphenyl)-1,2,5-oxadiazol-3-yl]-5-fluoro-3-methyl-1-benzofuran-2-carboxamide chemical structure, C20H16FN3O4, CAS 874400-00-7
N-[4-(4-Ethoxyphenyl)-1,2,5-oxadiazol-3-yl]-5-fluoro-3-methyl-1-benzofuran-2-carboxamide
CAS 874400-00-7C20H16FN3O4
6-Bromo-N-[4-(4-ethoxyphenyl)-1,2,5-oxadiazol-3-yl]-3-methyl-1-benzofuran-2-carboxamide chemical structure, C20H16BrN3O4, CAS 874400-06-3
6-Bromo-N-[4-(4-ethoxyphenyl)-1,2,5-oxadiazol-3-yl]-3-methyl-1-benzofuran-2-carboxamide
CAS 874400-06-3C20H16BrN3O4
N-[4-(3,4-Dimethoxyphenyl)-1,2,5-oxadiazol-3-yl]-3,5,6-trimethyl-1-benzofuran-2-carboxamide chemical structure, C22H21N3O5, CAS 929965-23-1
N-[4-(3,4-Dimethoxyphenyl)-1,2,5-oxadiazol-3-yl]-3,5,6-trimethyl-1-benzofuran-2-carboxamide
CAS 929965-23-1C22H21N3O5
5-Chloro-N-[4-(3,4-diethoxyphenyl)-1,2,5-oxadiazol-3-yl]-3-methyl-1-benzofuran-2-carboxamide chemical structure, C22H20ClN3O5, CAS 880408-19-5
5-Chloro-N-[4-(3,4-diethoxyphenyl)-1,2,5-oxadiazol-3-yl]-3-methyl-1-benzofuran-2-carboxamide
CAS 880408-19-5C22H20ClN3O5
N-[4-(3,4-Diethoxyphenyl)-1,2,5-oxadiazol-3-yl]-3-methyl-1-benzofuran-2-carboxamide chemical structure, C22H21N3O5, CAS 880408-23-1
N-[4-(3,4-Diethoxyphenyl)-1,2,5-oxadiazol-3-yl]-3-methyl-1-benzofuran-2-carboxamide
CAS 880408-23-1C22H21N3O5
5-Chloro-3,6-dimethyl-N-(4-phenyl-1,2,5-oxadiazol-3-yl)-1-benzofuran-2-carboxamide chemical structure, C19H14ClN3O3, CAS 880792-13-2
5-Chloro-3,6-dimethyl-N-(4-phenyl-1,2,5-oxadiazol-3-yl)-1-benzofuran-2-carboxamide
CAS 880792-13-2C19H14ClN3O3