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Murcko scaffold

Ring system with 4 rings and 26 atoms

15 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
15
With full pages
1
Scaffold SMILES

O=C(NN=Cc1cccs1)c1cc(-c2ccccc2)nc2ccccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NN=Cc1cccs1)c1cc(-c2ccccc2)nc2ccccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 15 of 15 chemicals

2-Phenyl-4-quinolinecarboxylic acid 2-[1-(5-chloro-2-thienyl)ethylidene]hydrazide chemical structure, C22H16ClN3OS, CAS 350988-45-3
2-Phenyl-4-quinolinecarboxylic acid 2-[1-(5-chloro-2-thienyl)ethylidene]hydrazide
CAS 350988-45-3C22H16ClN3OS
N-[(E)-(5-Chlorothiophen-2-yl)methylideneamino]-2-(2,5-dimethoxyphenyl)quinoline-4-carboxamide chemical structure, C23H18ClN3O3S, CAS 444933-89-5
N-[(E)-(5-Chlorothiophen-2-yl)methylideneamino]-2-(2,5-dimethoxyphenyl)quinoline-4-carboxamide
CAS 444933-89-5C23H18ClN3O3S
2-(4-Chlorophenyl)-N-[(E)-(5-methylthiophen-2-yl)methylideneamino]quinoline-4-carboxamide chemical structure, C22H16ClN3OS, CAS 351982-27-9
2-(4-Chlorophenyl)-N-[(E)-(5-methylthiophen-2-yl)methylideneamino]quinoline-4-carboxamide
CAS 351982-27-9C22H16ClN3OS
2-(2,4-Dimethoxyphenyl)-N'-[(3-methyl-2-thienyl)methylene]-4-quinolinecarbohydrazide chemical structure, C24H21N3O3S, CAS 445244-19-9
2-(2,4-Dimethoxyphenyl)-N'-[(3-methyl-2-thienyl)methylene]-4-quinolinecarbohydrazide
CAS 445244-19-9C24H21N3O3S
N-[(E)-(5-Chlorothiophen-2-yl)methylideneamino]-2-(2,4-dimethoxyphenyl)quinoline-4-carboxamide chemical structure, C23H18ClN3O3S, CAS 445244-33-7
N-[(E)-(5-Chlorothiophen-2-yl)methylideneamino]-2-(2,4-dimethoxyphenyl)quinoline-4-carboxamide
CAS 445244-33-7C23H18ClN3O3S
2-(2,4-Dimethoxyphenyl)-N'-[1-(5-methyl-2-thienyl)ethylidene]-4-quinolinecarbohydrazide chemical structure, C25H23N3O3S, CAS 522618-09-3
2-(2,4-Dimethoxyphenyl)-N'-[1-(5-methyl-2-thienyl)ethylidene]-4-quinolinecarbohydrazide
CAS 522618-09-3C25H23N3O3S
N'-[(E)-(5-Ethylthiophen-2-yl)methylidene]-6-methyl-2-[4-(propan-2-yl)phenyl]quinoline-4-carbohydrazide chemical structure, C27H27N3OS, CAS 522621-73-4
N'-[(E)-(5-Ethylthiophen-2-yl)methylidene]-6-methyl-2-[4-(propan-2-yl)phenyl]quinoline-4-carbohydrazide
CAS 522621-73-4C27H27N3OS
2-(2,4-Dimethoxyphenyl)-N'-[1-(2-thienyl)ethylidene]-4-quinolinecarbohydrazide chemical structure, C24H21N3O3S, CAS 445244-00-8
2-(2,4-Dimethoxyphenyl)-N'-[1-(2-thienyl)ethylidene]-4-quinolinecarbohydrazide
CAS 445244-00-8C24H21N3O3S
2-(2,4-Dimethoxyphenyl)-N'-[1-(2-thienyl)propylidene]-4-quinolinecarbohydrazide chemical structure, C25H23N3O3S, CAS 445244-18-8
2-(2,4-Dimethoxyphenyl)-N'-[1-(2-thienyl)propylidene]-4-quinolinecarbohydrazide
CAS 445244-18-8C25H23N3O3S
6-Methyl-2-[4-(propan-2-yl)phenyl]-N'-[(E)-thiophen-2-ylmethylidene]quinoline-4-carbohydrazide chemical structure, C25H23N3OS, CAS 522621-71-2
6-Methyl-2-[4-(propan-2-yl)phenyl]-N'-[(E)-thiophen-2-ylmethylidene]quinoline-4-carbohydrazide
CAS 522621-71-2C25H23N3OS
N'-[1-(5-Chloro-2-thienyl)ethylidene]-2-(2,4-dimethoxyphenyl)-4-quinolinecarbohydrazide chemical structure, C24H20ClN3O3S, CAS 522618-12-8
N'-[1-(5-Chloro-2-thienyl)ethylidene]-2-(2,4-dimethoxyphenyl)-4-quinolinecarbohydrazide
CAS 522618-12-8C24H20ClN3O3S
2-(4-Bromophenyl)-N'-[(5-chloro-2-thienyl)methylene]-4-quinolinecarbohydrazide chemical structure, C21H13BrClN3OS, CAS 444927-30-4
2-(4-Bromophenyl)-N'-[(5-chloro-2-thienyl)methylene]-4-quinolinecarbohydrazide
CAS 444927-30-4C21H13BrClN3OS
2-(2,4-Dimethoxyphenyl)-N'-[1-(5-ethyl-2-thienyl)ethylidene]-4-quinolinecarbohydrazide chemical structure, C26H25N3O3S, CAS 522618-08-2
2-(2,4-Dimethoxyphenyl)-N'-[1-(5-ethyl-2-thienyl)ethylidene]-4-quinolinecarbohydrazide
CAS 522618-08-2C26H25N3O3S
2-(4-Ethoxyphenyl)-N'-[(E)-(5-ethylthiophen-2-yl)methylidene]-6-methylquinoline-4-carbohydrazide chemical structure, C26H25N3O2S, CAS 522621-15-4
2-(4-Ethoxyphenyl)-N'-[(E)-(5-ethylthiophen-2-yl)methylidene]-6-methylquinoline-4-carbohydrazide
CAS 522621-15-4C26H25N3O2S
2-(4-Chlorophenyl)-N'-[(E)-(5-ethylthiophen-2-yl)methylidene]quinoline-4-carbohydrazide chemical structure, C23H18ClN3OS, CAS 724759-69-7
2-(4-Chlorophenyl)-N'-[(E)-(5-ethylthiophen-2-yl)methylidene]quinoline-4-carbohydrazide
CAS 724759-69-7C23H18ClN3OS